FlyBase Allele Report: Hsap\DSCAM[Dscam1.WT]

General Information

Symbol

Hsap\DSCAM^Dscam1.WT

Species

H. sapiens

Name

FlyBase ID

FBal0321632

Feature type

allele

Associated gene

Hsap\DSCAM

Associated Insertion(s)

Carried in Construct

P{Dscam1-hDSCAM.WT}

Key Links

Transgenic product class

cDNA

(Huang et al., 2011)

wild_type

(Huang et al., 2011)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Huang et al., 2011)

wild_type

(Huang et al., 2011)

Mutagen

in vitro construct

(Huang et al., 2011)

Progenitor genotype

Carried in construct

P{Dscam1-hDSCAM.WT}

Cytology

Description

A 4.5kb Dscam1 promoter fragment drives expression of a full-length Hsap\DSCAM cDNA.

(Huang et al., 2011)

Allele components

Component

Use(s)

Regulatory region(s)

Dscam1

Encoded product / tool

Hsap\DSCAM

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Down syndrome

modeled by Dscam1²¹, Dscam1^B17-1

(Huang et al., 2011)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Hsap\DSCAM^Dscam1.WT is a suppressor | partially of abnormal neuroanatomy | larval stage phenotype of Dscam1²¹/Dscam1^B17-1

(Huang et al., 2011)

Hsap\DSCAM^Dscam1.WT is a suppressor | partially of lethal - all die before end of P-stage phenotype of Dscam1²¹/Dscam1^B17-1

(Huang et al., 2011)

Hsap\DSCAML1^Dscam1.WT/Hsap\DSCAM^Dscam1.WT is a suppressor | partially of lethal - all die before end of P-stage phenotype of Dscam1²¹/Dscam1^B17-1

(Huang et al., 2011)

Hsap\DSCAM^Dscam1.WT/Dscam1^{B1.4.2-6.18-9.22-17.1} is a suppressor | partially of lethal - all die before end of P-stage phenotype of Dscam1²¹/Dscam1^B17-1

(Huang et al., 2011)

Hsap\DSCAM^Dscam1.WT/Dscam1^{C1.4.2-6.14-9.24-17.1} is a suppressor | partially of lethal - all die before end of P-stage phenotype of Dscam1²¹/Dscam1^B17-1

(Huang et al., 2011)

Hsap\DSCAM^Dscam1.WT/Dscam1^{B2.4.2-6.18-9.22-17.2} is a suppressor | partially of lethal - all die before end of P-stage phenotype of Dscam1²¹/Dscam1^B17-1

(Huang et al., 2011)

Hsap\DSCAM^Dscam1.WT/Dscam1^{C2.4.2-6.14-9.24-17.2} is a suppressor | partially of lethal - all die before end of P-stage phenotype of Dscam1²¹/Dscam1^B17-1

(Huang et al., 2011)

NOT Suppressor of

Statement

Reference

Hsap\DSCAM^Dscam1.WT is a non-suppressor of abnormal neuroanatomy | somatic clone | P-stage phenotype of Dscam1¹⁸

(Huang et al., 2011)

Other

Statement

Reference

Dscam1²¹/Dscam1^B17-1, Hsap\DSCAM^Dscam1.WT has visible phenotype

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1, Hsap\DSCAM^Dscam1.WT has short lived phenotype

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1, Hsap\DSCAM^Dscam1.WT has abnormal neuroanatomy | adult stage phenotype

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1, Hsap\DSCAM^Dscam1.WT has abnormal locomotor behavior | adult stage phenotype

(Huang et al., 2011)

Phenotype Manifest In

Suppressor of

Statement

Reference

Hsap\DSCAM^Dscam1.WT is a suppressor | partially of dendritic arborizing neuron | larval stage phenotype of Dscam1²¹/Dscam1^B17-1

(Huang et al., 2011)

NOT Suppressor of

Statement

Reference

Hsap\DSCAM^Dscam1.WT is a non-suppressor of adult MBp lineage neuron | somatic clone | P-stage phenotype of Dscam1¹⁸

(Huang et al., 2011)

Hsap\DSCAM^Dscam1.WT is a non-suppressor of axon | somatic clone | P-stage phenotype of Dscam1¹⁸

(Huang et al., 2011)

Other

Statement

Reference

Dscam1²¹/Dscam1^B17-1, Hsap\DSCAM^Dscam1.WT has wing | adult stage phenotype

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1, Hsap\DSCAM^Dscam1.WT has adult mushroom body | adult stage phenotype

(Huang et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\DSCAM^Dscam1.WT largely rescues the dendritic arborization neuron self-avoidance defects, and partially rescues the lethality of Dscam1²¹/Dscam1^B17-1 mutants, with an increased proportion of mutants developing to late pupal stage, and a small number of adults emerging. The majority of these adults are immobile and have unexpanded wings, and die a few days after eclosion. The mushroom bodies in these adults exhibit abnormal morphology, with either no lobes or only one lobe projecting medially or dorsally.

Expression of both Hsap\DSCAML1^Dscam1.WT and Hsap\DSCAM^Dscam1.WT, or both Hsap\DSCAM^Dscam1.WT and Dscam1^{B1.4.2-6.18-9.22-17.1}, or both Hsap\DSCAM^Dscam1.WT and Dscam1^{C1.4.2-6.14-9.24-17.1}, partially rescues the lethality of Dscam1²¹/Dscam1^B17-1 mutants, with an increased proportion of mutants developing to late pupal stage, and a small number of adults emerging.

Expression of both Hsap\DSCAM^Dscam1.WT and Dscam1^{B2.4.2-6.18-9.22-17.2}, or both Hsap\DSCAM^Dscam1.WT and Dscam1^{C2.4.2-6.14-9.24-17.2}, substantially rescues the lethality of Dscam1²¹/Dscam1^B17-1 mutants, with a majority of mutants developing to late pupal stages.

Expression of Hsap\DSCAM^Dscam1.WT fails to rescue the axon segregation and additional sister branch defects of Dscam1¹⁸/Dscam1¹⁸ late pupal MB neuron clones.

(Huang et al., 2011)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Hsap\DSCAM^Dscam1.WT

Name Synonyms

Secondary FlyBase IDs

References (1)

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