Open Close
General Information
Symbol
Dmel\Dscam1B17-1
Species
D. melanogaster
Name
FlyBase ID
FBal0213020
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
DscamB17-1
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the insertion in Dscam05518, resulting in a deletion of sequences in the Dscam exon 4 cluster.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Most Dscam121/Dscam1B17-1 mutants die at early larval stages, with the remainder dying before eclosion, and dendritic arborization neurons exhibit self-avoidance defects.

Surviving adults of Dscam121/Dscam1B17-1 mutants expressing Dscam1B1.4.2-6.18-9.22-17.1, Dscam1B2.4.2-6.18-9.22-17.2, Dscam1C1.4.2-6.14-9.24-17.1, Dscam1C2.4.2-6.14-9.24-17.2, both Dscam1B2.4.2-6.18-9.22-17.2 and Dscam1C1.4.2-6.14-9.24-17.1, or both Dscam1B1.4.2-6.18-9.22-17.1 and Dscam1C2.4.2-6.14-9.24-17.2, are largely immobile, have unexpanded wings, and die a few days after eclosion. The mushroom bodies in these adults exhibit abnormal morphology, with either no lobes or only one lobe projecting medially or dorsally.

Single cell clones of mushroom body α/β neurons that are homozygous for DscamB17-1 show axon branching defects, such as the generation of additional branches.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
NOT suppressed by
Other
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Expression of both Hsap\DSCAML1Dscam1.WT and Hsap\DSCAMDscam1.WT, or both Hsap\DSCAMDscam1.WT and Dscam1B1.4.2-6.18-9.22-17.1, or both Hsap\DSCAMDscam1.WT and Dscam1C1.4.2-6.14-9.24-17.1, or both Hsap\DSCAML1Dscam1.WT and Dscam1B1.4.2-6.18-9.22-17.1, or both Hsap\DSCAML1Dscam1.WT and Dscam1C1.4.2-6.14-9.24-17.1, partially rescues the lethality of Dscam121/Dscam1B17-1 mutants, with an increased proportion of mutants developing to late pupal stage, and a small number of adults emerging.

Expression of Hsap\DSCAML1Dscam1.WT or Hsap\DSCAMDscam1.WT largely rescues the dendritic arborization neuron self-avoidance defects, and partially rescues the lethality of Dscam121/Dscam1B17-1 mutants, with an increased proportion of mutants developing to late pupal stage, and a small number of adults emerging. The majority of these adults are immobile and have unexpanded wings, and die a few days after eclosion. The mushroom bodies in these adults exhibit abnormal morphology, with either no lobes or only one lobe projecting medially or dorsally.

Expression of Hsap\DSCAMT.Dscam1.T:Avic\GFP or Hsap\DSCAML1T.Dscam1.T:Avic\GFP fails to rescue the larval lethality of Dscam121/Dscam1B17-1 mutants.

Expression of both Hsap\DSCAMDscam1.WT and Dscam1B2.4.2-6.18-9.22-17.2, or both Hsap\DSCAMDscam1.WT and Dscam1C2.4.2-6.14-9.24-17.2, or both Hsap\DSCAML1Dscam1.WT and Dscam1B2.4.2-6.18-9.22-17.2, or both Hsap\DSCAML1Dscam1.WT and Dscam1C2.4.2-6.14-9.24-17.2, substantially rescues the lethality of Dscam121/Dscam1B17-1 mutants, with a majority of mutants developing to late pupal stages.

Complementation and Rescue Data
Comments

Expression of Dscam1A1.4.3-6.36-9.25-17.1, Dscam1A2.4.3-6.36-9.25-17.2, Dscam1B1.4.2-6.18-9.22-17.1, Dscam1B2.4.2-6.18-9.22-17.2, or both Dscam1B1.4.2-6.18-9.22-17.1 and Dscam1C1.4.2-6.14-9.24-17.1, or both Dscam1B2.4.2-6.18-9.22-17.2 and Dscam1C2.4.2-6.14-9.24-17.2, partially rescues the lethality of Dscam121/Dscam1B17-1 mutants, with an increased proportion of mutants developing to late pupal stage, and a small number of adults emerging.

Expression of Dscam1C1.4.2-6.14-9.24-17.1 partially rescues the lethality of Dscam121/Dscam1B17-1 mutants, with an increased proportion of mutants developing to late pupal stage, and a small number of adults emerging; and largely rescues the dendritic arborization neuron self-avoidance defects of Dscam121/Dscam1B17-1 mutants.

Expression of both Dscam1B1.4.2-6.18-9.22-17.1 and Dscam1B2.4.2-6.18-9.22-17.2, or both Dscam1B1.4.2-6.18-9.22-17.1 and Dscam1C2.4.2-6.14-9.24-17.2, or both Dscam1B2.4.2-6.18-9.22-17.2 and Dscam1C1.4.2-6.14-9.24-17.1, or both Dscam1C1.4.2-6.14-9.24-17.1 and Dscam1C2.4.2-6.14-9.24-17.2, almost completely rescues the lethality of Dscam121/Dscam1B17-1 mutants, with most mutants developing to pupal stage.

Expression of Dscam1C2.4.2-6.14-9.24-17.2 partially rescues the lethality of Dscam121/Dscam1B17-1 mutants, with an increased proportion of mutants developing to late pupal stage, and a small number of adults emerging, but fails to rescue the dendritic arborization neuron self-avoidance defects of Dscam121/Dscam1B17-1 mutants.

Expression of Dscam1C1T.4.2-6.14-9.24-17.1.T:Avic\GFP or Dscam1C2T.4.2-6.14-9.24-17.2.T:Avic\GFP fails to rescue the larval lethality of Dscam121/Dscam1B17-1 mutants.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (3)