FlyBase Allele Report: Dmel\shd[HMC06461]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\shd^HMC06461

General Information

Symbol

Dmel\shd^HMC06461

Species

D. melanogaster

Name

FlyBase ID

FBal0324062

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{TRiP.HMC06461}

Key Links

Genomic Maps

Transgenic product class

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HMC06461}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Also carries

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates carcinoma

modeled by Ras85D^V12.UAS, dlg1^GD4689

(Santabárbara-Ruiz and Léopold, 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell growth rate | adult stage | male, with Scer\GAL4^esg.PU

(Sekar et al., 2023)

decreased cell number | adult stage, with Scer\GAL4^Tk.PS

(Jugder et al., 2021)

Phenotype Manifest In

adult anterior midgut, with Scer\GAL4^Tk.PS

(Jugder et al., 2021)

adult enteroendocrine cell | decreased number, with Scer\GAL4^Tk.PS

(Jugder et al., 2021)

lipid droplet | adult stage, with Scer\GAL4^Tk.PS

(Jugder et al., 2021)

male accessory gland secondary cell, with Scer\GAL4^esg.PU

(Sekar et al., 2023)

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

shd^HMC06461, Scer\GAL4^esg.PU is an enhancer of increased cell growth rate | adult stage | male phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^esg.PU

(Sekar et al., 2023)

NOT Suppressor of

Statement

Reference

shd^HMC06461, Scer\GAL4^esg.PU is a non-suppressor of abnormal cell cycle | male | adult stage phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^esg.PU

(Sekar et al., 2023)

Phenotype Manifest In

Enhancer of

Statement

Reference

shd^HMC06461, Scer\GAL4^esg.PU is an enhancer of male accessory gland secondary cell phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^esg.PU

(Sekar et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

67356

y¹ sc^* v¹ sev²¹; P{TRiP.HMC06461}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Shade^RNAi

(Jugder et al., 2021)

shd^HMC06461

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections