FlyBase Allele Report: Dmel\tea[2-1]

General Information

Symbol

Dmel\tea^2-1

Species

D. melanogaster

Name

FlyBase ID

FBal0324689

Feature type

allele

Associated gene

Dmel\tea

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

gene targeting by homologous recombination

Nature of the Allele

Allele class

Mutagen

gene targeting by homologous recombination

(Zhang et al., 2016)

Progenitor genotype

Cytology

Description

Recovered during SIRT gene targeting, may belong to a class III gene targeting event in which both copies of the tea gene are disrupted by small rearrangements during the homologous recombination process.

(Zhang et al., 2016)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

chromosome

(Zhang et al., 2016)

chromosome (with Df(2R)BSC298)

(Zhang et al., 2016)

chromosome | larval stage (with tea¹⁷⁵⁵)

(Zhang et al., 2016)

Detailed Description

Statement

Reference

tea^2-1 homozygotes as well as tea^2-1/Df(2R)BSC298 or tea¹⁷⁵⁵/tea^2-1 mutants are larval lethal and their cells display high frequency of end-to-end chromosomal fusions during mitosis.

(Zhang et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

tea¹⁷⁵⁵/tea^2-1 is rescued by tea^+t10

(Zhang et al., 2016)

Df(2R)BSC298/tea^2-1 is rescued by tea^+t10

(Zhang et al., 2016)

tea^2-1 is rescued by tea^+t10

(Zhang et al., 2016)

Comments

The larval lethality and chromosome end fusions characteristic for tea^2-1 homozygotes, tea^2-1/tea¹⁷⁵⁵ transheterozygotes or tea^2-1/Df(2R)BSC298 mutants are each rescued by combination with tea^+t10.

(Zhang et al., 2016)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

tea^2-1

(Zhang et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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