FlyBase Gene Report: Dmel\tea

General Information

Symbol

Dmel\tea

Species

D. melanogaster

Name

telomere ends associated

Annotation Symbol

CG30007

Feature Type

protein_coding_gene

FlyBase ID

FBgn0285892

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Part of the MTV complex that associates with the HipHop-HOAP complex to form the terminin telomere-capping complex involved in telomere maintenance and prevention of telomere fusion (PubMed:27835648). As part of the MTV complex binds single stranded DNA in a sequence-independent manner, protecting it from degradation (PubMed:27835648). May mediate recruitment of the MTV complex at telomeres through interaction with components of the HipHop-HOAP complex (PubMed:27835648). (UniProt, E1JH25)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

46C2-46C4

Sequence location

2R:9,891,955..9,898,513 [+]

Recombination map

2-61

RefSeq locus

NT_033778 REGION:9891955..9898513

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (3 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

contributes_to single-stranded telomeric DNA binding

inferred from direct assay

(Zhang et al., 2016)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in telomere capping

inferred from direct assay

(Zhang et al., 2016)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of telomere cap complex

inferred from direct assay

(Zhang et al., 2016)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

MTV COMPLEX

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

MTV COMPLEX -: The Moi-Tea-Ver (MTV) complex binds single-stranded DNA in a sequence independent manner, protecting the DNA from cleavage by endonucleases. Binds the HipHop-HOAP complex to form terminin telomere-capping complex which binds to chromosome ends in a sequence-independent manner and prevents telomere fusion. (Adapted from ComplexPortal.)

Protein Function (UniProtKB)

(UniProt, E1JH25)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\tea for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry E1JH25)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

tea-RB

FBtr0088381

NM_136689

5297

1693

tea-RC

FBtr0300919

NM_001169634

5806

1876

tea-RD

FBtr0300920

NM_001169635

5291

1691

tea-RE

FBtr0300921

NM_165719

5812

1878

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

tea-PB

FBpp0087469

191.1

1693

6.26

FBpp0290141

211.8

1876

6.22

FBpp0290142

190.9

1691

6.26

FBpp0290143

212.0

1878

6.22

A1Z818

NP_724855

AAF58877

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Component of the MTV complex, composed of moi/modigliani, tea and ver/verrocchio (PubMed:27835648). Interacts (via C-terminus) with moi/modigliani and ver/verrocchio; the interactions are direct and require fully intact moi/modigliani and ver/verrocchio (PubMed:27835648). The MTV complex is recruited to telomeres by the HipHop-HOAP complex, consisting of HipHop, cav/HOAP and Su(var)205/HP1 to form the terminin telomere-capping complex (PubMed:27835648).

(UniProt, E1JH25)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\tea using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.23

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010, Dorus et al., 2006)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of telomere cap complex

inferred from direct assay

(Zhang et al., 2016)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\tea in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\tea

View exonic expression by tissue for Dmel\tea

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36027/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0285892

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0050007

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0285892

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG30007

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of tea

Transgenic constructs containing regulatory region of tea

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene disrupted in

Df(2R)221

(O'Brien et al., 1994)

Df(2R)232

(O'Brien et al., 1994)

Df(2R)520

(O'Brien et al., 1994)

Df(2R)521

(O'Brien et al., 1994)

Df(2R)BSC158

(Kahsai et al., 2016)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

tea¹⁷⁵⁵

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

tea^GD9963

lethal, with Scer\GAL4^insc-Mz1407

tea^GD9963

lethal (with Df(2R)BSC158)

tea^SH0071

lethal | recessive

tea^SH0071

lethal - all die during embryonic stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

tea^GD9963

partially lethal - majority die, with Scer\GAL4^pnr-MD237

tea^GD9963

Other Phenotypes

Allele

abnormal flight, with Scer\GAL4^Mef2.PR

tea^GD9963

abnormal neuroanatomy | larval stage, with Scer\GAL4^insc-Mz1407

tea^GD9963

some die during pupal stage, with Scer\GAL4^pnr-MD237

tea^GD9963

visible, with Scer\GAL4^pnr-MD237

tea^GD9963

Phenotype manifest in

Allele

chromosome

tea^2-1

chromosome (with Df(2R)BSC298)

chromosome | larval stage (with tea^2-1)

tea¹⁷⁵⁵

chromosome | larval stage (with tea¹⁷⁵⁵)

tea^2-1

ganglion mother cell | larval stage, with Scer\GAL4^insc-Mz1407

tea^GD9963

larval neuroblast | larval stage, with Scer\GAL4^insc-Mz1407

tea^GD9963

mesonotum, with Scer\GAL4^pnr-MD237

tea^GD9963

trichogen cell, with Scer\GAL4^pnr-MD237

tea^GD9963

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (7)

Hsap\ELOVL1

1 of 14

Yes

Hsap\ELOVL2

1 of 14

Yes

Hsap\ELOVL3

1 of 14

Yes

Hsap\ELOVL4

1 of 14

Yes

Hsap\ELOVL5

1 of 14

Yes

Hsap\ELOVL6

1 of 14

Yes

Hsap\ELOVL7

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (7)

Rnor\Elovl1

1 of 14

Yes

Rnor\Elovl2

1 of 14

Yes

Rnor\Elovl3

1 of 14

Yes

Rnor\Elovl4

1 of 14

Yes

Rnor\Elovl5

1 of 14

Yes

Rnor\Elovl6

1 of 14

Yes

Rnor\Elovl7

1 of 14

Yes

Mus musculus (laboratory mouse) (7)

Mmus\Elovl1

1 of 14

Yes

Mmus\Elovl2

1 of 14

Yes

Mmus\Elovl3

1 of 14

Yes

Mmus\Elovl4

1 of 14

Yes

Mmus\Elovl5

1 of 14

Yes

Mmus\Elovl6

1 of 14

Yes

Mmus\Elovl7

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (3)

Xtro\cers3

1 of 13

Yes

Xtro\jakmip1

1 of 13

Yes

Xtro\pkmyt1

1 of 13

Yes

Danio rerio (Zebrafish) (10)

Drer\elovl2

1 of 14

Yes

Drer\elovl4a

1 of 14

Yes

Drer\elovl4b

1 of 14

Yes

Drer\elovl5

1 of 14

Yes

Drer\elovl6

1 of 14

Yes

Drer\elovl6l

1 of 14

Yes

Drer\elovl7a

1 of 14

Yes

Drer\elovl8a

1 of 14

Yes

Drer\elovl8b

1 of 14

Yes

Drer\zgc:92749

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\elo-2

1 of 14

Yes

Cele\elo-4

1 of 14

Yes

Cele\elo-5

1 of 14

Yes

Cele\elo-6

1 of 14

Yes

Cele\elo-9

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (19)

Agam\AgaP_AGAP001097

1 of 12

Yes

Agam\AgaP_AGAP003195

1 of 12

Yes

Agam\AgaP_AGAP003196

1 of 12

Yes

Agam\AgaP_AGAP003197

1 of 12

Yes

Agam\AgaP_AGAP003600

1 of 12

Yes

Agam\AgaP_AGAP004372

1 of 12

Yes

Agam\AgaP_AGAP005511

1 of 12

Yes

Agam\AgaP_AGAP005512

1 of 12

Yes

Agam\AgaP_AGAP005513

1 of 12

Yes

Agam\AgaP_AGAP006520

1 of 12

Yes

Agam\AgaP_AGAP007134

1 of 12

Yes

Agam\AgaP_AGAP007264

1 of 12

Yes

Agam\AgaP_AGAP008780

1 of 12

Yes

Agam\AgaP_AGAP008781

1 of 12

Yes

Agam\AgaP_AGAP010695

1 of 12

Yes

Agam\AgaP_AGAP011812

1 of 12

Yes

Agam\AgaP_AGAP011848

1 of 12

Yes

Agam\AgaP_AGAP013094

1 of 12

Yes

Agam\AgaP_AGAP013219

1 of 12

Yes

Arabidopsis thaliana (thale-cress) (4)

Atha\AT1G75000

1 of 13

Yes

Atha\AT3G06460

1 of 13

Yes

Atha\AT3G06470

1 of 13

Yes

Atha\HOS3-1

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\ELO1

1 of 13

Yes

Scer\ELO2

1 of 13

Yes

Scer\ELO3

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\SPAC1B2.03c

1 of 12

Yes

Spom\SPAC1639.01c

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:tea. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (21)

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

sit

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

tea - Scm

tandem affinity purification, Identification by mass spectrometry

(Kang et al., 2015)

tea - Su(var)205

anti tag coimmunoprecipitation, peptide massfingerprinting

(Alekseyenko et al., 2014)

tea - cav

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Zhang et al., 2016)

tea - moi

anti tag coimmunoprecipitation, molecular weight estimation by staining, protein three hybrid

(Zhang et al., 2016)

tea - ver

anti tag coimmunoprecipitation, molecular weight estimation by staining, anti tag western blot, protein three hybrid, affinity technology, Identification by mass spectrometry

(Cicconi et al., 2017, Zhang et al., 2016)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

(UniProt, E1JH25 )

Linkouts

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-61

Cytogenetic map

46C2-46C4

Sequence location

2R:9,891,955..9,898,513 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

46C2-46C4

Left limit from in situ hybridisation (FBrf0157097) Right limit from in situ hybridisation (FBrf0157097)

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

46C2-46C4

(Oh et al., 2003)

46C-46C

(O'Brien et al., 1994)

Experimentally Determined Recombination Data

Location

2-61

(FlyBase, 2016)

2-60.0

(Comeron et al., 2012)

(O'Brien et al., 1994)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

29466

w^*; P{FRT(w^hs)}G13 P{lacW}tea^SH0071/CyO

83973

y¹ sc^* v¹ sev²¹; P{TKO.GS04055}attP40

67965

y¹ sc^* v¹ sev²¹; P{TRiP.HMS05826}attP40

4082

Adh^* pr¹ cn¹ tea¹⁷⁵⁵/CyO, Adh^nB

10682

y¹ w^67c23; P{lacW}l(2)k07803^k07803 P{lacW}tea^k07803/CyO

VDRC

v21053

w¹¹¹⁸; P{GD9963}v21053

Genomic Clones (27)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (23)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI17840

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

LP13587

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

1 allele of l(2)SH0071 recovered in a P-insertion screen.

(Oh et al., 2003)

Locus is located about 15kb upstream of the Fmrf gene.

(O'Brien et al., 1994)

Relationship to Other Genes

Source for database merge of

Source for merge of: l(2)46Cc CG30007 l(2)SH0071

(Zhang et al., 2016)

Additional comments

Annotation CG12138 split into CG30007 and CG30008 in release 3 of the genome annotation. Release 2 annotation CG12922 (which was eliminated in release 3 of the genome annotation) overlaps the same region of the genome, on the same strand, as release 3 annotation CG30007 but the intron/exon structure of the two annotations is different.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

The gene is named 'telomere ends associated' based on localization to telomeres.

(Zhang et al., 2016)

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

CG12138

CG30007

(Cicconi et al., 2017, Zhang et al., 2016, Hosono et al., 2015, Kang et al., 2015, Alekseyenko et al., 2014, Thomae et al., 2013, Buffin and Gho, 2010, Wasbrough et al., 2010, Perkins et al., 2009, Dorus et al., 2006)

III

(O'Brien et al., 1994)

TEA

(Vedelek et al., 2021)

Tea

(Cacchione et al., 2025, Melnikova and Golovnin, 2023, Cacchione et al., 2020, Cheng et al., 2018, Kordyukova et al., 2018, Zhang et al., 2016)

l(2)46Cc

l(2)SH0071

l(2)SH2 0071

(Oh et al., 2002.3.21)

tea

(Rounds et al., 2022, Li et al., 2020, Meyer-Nava et al., 2020, Cicconi et al., 2017, Transgenic RNAi Project members, 2017-, Zhang et al., 2016)

Name Synonyms

Group III

(O'Brien et al., 1994)

Telomere Ends Associated, D

(Dobens et al., 2021)

lethal (2) 46Cc

(O'Brien et al., 1994)

lethal (2) SH0071

telomere ends associated

(Zhang et al., 2016)

Secondary FlyBase IDs

FBgn0014982
FBgn0050007
FBgn0033462
FBgn0065951

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 43 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36027

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

E1JH25

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

E1JH25

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

E1JH25

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36027/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0285892

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0285892

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG30007

MARRVEL_MODEL - MARRVEL (model organism gene)

36027

Linkouts

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0050007

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0285892

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG30007

References (44)

The following external sites may use different assemblies or annotations than FlyBase.

0.23

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