FB2021_02, released April 13, 2021

Gene: Dmel\Elovl7

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General Information
Symbol
Dmel\Elovl7
Species
D. melanogaster
Name
ELOVL fatty acid elongase 7
Annotation Symbol
CG2781
Feature Type
protein_coding_gene
FlyBase ID
FBgn0037534
Gene Model Status
Current
Stock Availability
5 publicly available
Gene Summary
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. (UniProt, Q9VHX7)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

dELOVL, ELOVL

Key Links
Genomic Location
Cytogenetic map
84E6-84E7
Sequence location
3R:7,981,817..7,995,852 [-]
Recombination map
3-48
RefSeq locus
NT_033777 REGION:7981817..7995852
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables fatty acid elongase activity
inferred from sequence or structural similarity with FLYBASE:bond; FB:FBgn0260942
(Szafer-Glusman et al., 2008)
inferred from biological aspect of ancestor with PANTHER:PTN000125390
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (7 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in long-chain fatty acid metabolic process
inferred from mutant phenotype
(assigned by UniProt )
(Gordon et al., 2018)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
involved_in fatty acid elongation, monounsaturated fatty acid
inferred from biological aspect of ancestor with PANTHER:PTN000125390
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in fatty acid elongation, polyunsaturated fatty acid
inferred from biological aspect of ancestor with PANTHER:PTN000125390
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in fatty acid elongation, saturated fatty acid
inferred from biological aspect of ancestor with PANTHER:PTN000125390
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in fatty acid elongation
inferred from sequence or structural similarity with FLYBASE:bond; FB:FBgn0260942
(Szafer-Glusman et al., 2008)
involved_in sphingolipid biosynthetic process
inferred from biological aspect of ancestor with PANTHER:PTN000125390
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in very long-chain fatty acid biosynthetic process
inferred from biological aspect of ancestor with PANTHER:PTN000125390
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in integral component of endoplasmic reticulum membrane
inferred from biological aspect of ancestor with PANTHER:PTN000125390
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the ELO family. (Q9VHX7)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
FATTY ACID ELONGASES -
Fatty acid elongases are conserved from yeast to mammals and mediate elongation of fatty acids into very-long-chain fatty acids (VLCFAs, i.e. with acyl chains of 18 carbon atoms or longer). They are bound to the endoplasmic reticulum membrane where they are believed to perform the first step (condensation) in the elongation cycle. VLCFAs are most commonly found in sphingolipids and are essential for sphingolipid formation and function. (Adapted from PMID:16564093.)
Protein Function (UniProtKB)
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle.
(UniProt, Q9VHX7)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Elovl7 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Elovl7-RA
FBtr0081823
NM_141497
1974
329
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Elovl7-PA
FBpp0081313
38.4
329
9.83
NP_649754
AAF54172
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Elovl7 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult fat body

Comment: cyclical, peak ZT17-20

(Xu et al., 2011)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 13 -- 16
atrium
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic epipharynx
(Fisher et al., 2012)
embryonic esophagus
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic hypopharynx
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic/larval posterior spiracle
(Fisher et al., 2012)
Additional Descriptive Data

Expressed cyclically in the adult fat body.

(Xu et al., 2011)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Elovl7 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Elovl7
Transgenic constructs containing regulatory region of Elovl7
Aberrations (Deficiencies and Duplications) ( 1 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ELOVL7
15 of 15
Yes
Yes
Hsap\ELOVL1
11 of 15
No
No
1  
Hsap\ELOVL2
5 of 15
No
No
Hsap\ELOVL4
5 of 15
No
No
Hsap\ELOVL5
4 of 15
No
No
Hsap\ELOVL3
2 of 15
No
No
Hsap\ELOVL6
2 of 15
No
No
1  
Hsap\MIR6734
2 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Elovl7
15 of 15
Yes
Yes
Mmus\Elovl1
11 of 15
No
No
Mmus\Elovl2
5 of 15
No
No
Mmus\Elovl4
5 of 15
No
No
Mmus\Elovl5
4 of 15
No
No
Mmus\Elovl3
2 of 15
No
No
Mmus\Elovl6
1 of 15
No
No
Rattus norvegicus (Norway rat) (8)
Rnor\Elovl7
12 of 13
Yes
Yes
Rnor\Elovl1
11 of 13
No
No
Rnor\Elovl2
4 of 13
No
No
Rnor\Elovl4
4 of 13
No
No
Rnor\Elovl5
3 of 13
No
No
Rnor\Elovl3
2 of 13
No
No
Rnor\LOC102549542
2 of 13
No
No
Rnor\Elovl6
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (10)
Xtro\elovl7
8 of 12
Yes
Yes
Xtro\elovl1
7 of 12
No
No
Xtro\elovl2
4 of 12
No
Yes
Xtro\elovl5
4 of 12
No
Yes
Xtro\elovl3
2 of 12
No
No
Xtro\elovl4
2 of 12
No
No
Xtro\elovl6
2 of 12
No
No
Xtro\LOC101732387
2 of 12
No
Yes
Xtro\LOC101733189
2 of 12
No
Yes
Xtro\LOC101731836
1 of 12
No
No
Danio rerio (Zebrafish) (13)
Drer\elovl1a
10 of 15
Yes
No
Drer\elovl1b
10 of 15
Yes
No
Drer\elovl7b
10 of 15
Yes
Yes
Drer\elovl7a
9 of 15
No
Yes
Drer\elovl2
5 of 15
No
No
Drer\elovl4a
5 of 15
No
No
Drer\elovl4b
5 of 15
No
No
Drer\elovl5
4 of 15
No
No
Drer\elovl8a
4 of 15
No
No
Drer\elovl8b
4 of 15
No
No
Drer\elovl6
2 of 15
No
No
Drer\elovl6l
2 of 15
No
No
Drer\zgc:92749
2 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (9)
Cele\elo-1
4 of 15
Yes
No
Cele\elo-6
3 of 15
No
No
Cele\elo-7
3 of 15
No
No
Cele\elo-2
2 of 15
No
No
Cele\elo-3
2 of 15
No
No
Cele\elo-4
2 of 15
No
No
Cele\elo-5
2 of 15
No
No
Cele\elo-8
2 of 15
No
No
Cele\elo-9
2 of 15
No
No
Arabidopsis thaliana (thale-cress) (4)
Atha\AT3G06460
4 of 9
Yes
Yes
Atha\AT3G06470
4 of 9
Yes
Yes
Atha\HOS3-1
2 of 9
No
No
Atha\AT1G75000
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\ELO2
8 of 15
Yes
Yes
Scer\ELO3
5 of 15
No
No
Scer\ELO1
4 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\SPAC1B2.03c
6 of 12
Yes
Yes
Spom\SPAC1639.01c
4 of 12
No
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190ART )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00013229
Drosophila simulans
Dsim\GD19443
Drosophila sechellia
Dsec\GM10441
Drosophila erecta
Dere\GG24795
Drosophila yakuba
Dyak\GE11104
Drosophila yakuba
Dyak\GE25754
Drosophila ananassae
Dana\GF16560
Drosophila pseudoobscura pseudoobscura
Dpse\GA15460
Drosophila persimilis
Dper\GL23546
Drosophila willistoni
Dwil\GK13951
Drosophila virilis
Dvir\GJ24115
Drosophila mojavensis
Dmoj\GI22067
Drosophila grimshawi
Dgri\GH18531
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150630 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17019921
Musca domestica
House fly
Mdoa\17012142
Musca domestica
House fly
Mdoa\17008615
Musca domestica
House fly
Mdoa\17014405
Glossina morsitans
Tsetse fly
Gmor\GMOY002619
Glossina morsitans
Tsetse fly
Gmor\GMOY002618
Glossina morsitans
Tsetse fly
Gmor\GMOY008209
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11661
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_06674
Mayetiola destructor
Hessian fly
Mdes\Mdes002507
Mayetiola destructor
Hessian fly
Mdes\Mdes002509
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL007216
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL008004
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL009574
Anopheles darlingi
American malaria mosquito
Adar\ADAC006797
Anopheles darlingi
American malaria mosquito
Adar\ADAC006003
Anopheles darlingi
American malaria mosquito
Adar\ADAC006001
Anopheles gambiae
Malaria mosquito
Agam\AGAP004372
Anopheles gambiae
Malaria mosquito
Agam\AGAP004373
Anopheles gambiae
Malaria mosquito
Agam\AGAP003600
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ014005
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ019159
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ003715
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ019160
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0A7U )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA000291
Bombyx mori
Silkmoth
Bmor\BGIBMGA010922
Bombyx mori
Silkmoth
Bmor\BGIBMGA010945
Bombyx mori
Silkmoth
Bmor\BGIBMGA010921
Bombyx mori
Silkmoth
Bmor\BGIBMGA000422
Bombyx mori
Silkmoth
Bmor\BGIBMGA010919
Bombyx mori
Silkmoth
Bmor\BGIBMGA010918
Bombyx mori
Silkmoth
Bmor\BGIBMGA000424
Danaus plexippus
Monarch butterfly
Dple\DPOGS211377-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS209918-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS211375-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS215875-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS209934-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS215920-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS215874-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS211376-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL009766
Heliconius melpomene
Postman butterfly
Hmel\HMEL017506
Heliconius melpomene
Postman butterfly
Hmel\HMEL004894
Heliconius melpomene
Postman butterfly
Hmel\HMEL009764
Heliconius melpomene
Postman butterfly
Hmel\HMEL017511
Heliconius melpomene
Postman butterfly
Hmel\HMEL017504
Heliconius melpomene
Postman butterfly
Hmel\HMEL005408
Apis florea
Little honeybee
Aflo\2169865410
Apis florea
Little honeybee
Aflo\2165057682
Apis florea
Little honeybee
Aflo\3385891812
Apis florea
Little honeybee
Aflo\2346876004
Apis florea
Little honeybee
Aflo\2346876196
Apis florea
Little honeybee
Aflo\2346875908
Apis florea
Little honeybee
Aflo\2346876036
Apis mellifera
Western honey bee
Amel\GB51250
Apis mellifera
Western honey bee
Amel\GB54302
Apis mellifera
Western honey bee
Amel\Ame.17083
Apis mellifera
Western honey bee
Amel\LOC550828
Apis mellifera
Western honey bee
Amel\LOC552205
Apis mellifera
Western honey bee
Amel\GB51247
Apis mellifera
Western honey bee
Amel\LOC724552
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20099
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20086
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20093
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20094
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20097
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20096
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20092
Bombus terrestris
Buff-tailed bumblebee
Bter\15205907
Bombus terrestris
Buff-tailed bumblebee
Bter\15205912
Bombus terrestris
Buff-tailed bumblebee
Bter\15205909
Bombus terrestris
Buff-tailed bumblebee
Bter\15205914
Bombus terrestris
Buff-tailed bumblebee
Bter\15205905
Bombus terrestris
Buff-tailed bumblebee
Bter\15205906
Bombus terrestris
Buff-tailed bumblebee
Bter\15205913
Linepithema humile
Argentine ant
Lhum\LH17400
Linepithema humile
Argentine ant
Lhum\LH25667
Linepithema humile
Argentine ant
Lhum\LH17398
Linepithema humile
Argentine ant
Lhum\LH17402
Linepithema humile
Argentine ant
Lhum\LH17397
Linepithema humile
Argentine ant
Lhum\LH25665
Linepithema humile
Argentine ant
Lhum\LH10542
Linepithema humile
Argentine ant
Lhum\LH16891
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000678
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000674
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000681
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000680
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000677
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000679
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00067f
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG018103
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG018116
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG018119
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG018104
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG018114
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG018102
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG018106
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00216
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12941
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12924
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12925
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12923
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10051
Tribolium castaneum
Red flour beetle
Tcas\TC016278
Tribolium castaneum
Red flour beetle
Tcas\TC016280
Tribolium castaneum
Red flour beetle
Tcas\TC034276
Tribolium castaneum
Red flour beetle
Tcas\TC011938
Tribolium castaneum
Red flour beetle
Tcas\TC002898
Tribolium castaneum
Red flour beetle
Tcas\TC010977
Tribolium castaneum
Red flour beetle
Tcas\TC034274
Tribolium castaneum
Red flour beetle
Tcas\TC011937
Tribolium castaneum
Red flour beetle
Tcas\TC016279
Tribolium castaneum
Red flour beetle
Tcas\TC002899
Pediculus humanus
Human body louse
Phum\PHUM381320
Pediculus humanus
Human body louse
Phum\PHUM576950
Pediculus humanus
Human body louse
Phum\PHUM381550
Pediculus humanus
Human body louse
Phum\PHUM494510
Pediculus humanus
Human body louse
Phum\PHUM576820
Pediculus humanus
Human body louse
Phum\PHUM047320
Pediculus humanus
Human body louse
Phum\PHUM381440
Pediculus humanus
Human body louse
Phum\PHUM381330
Rhodnius prolixus
Kissing bug
Rpro\RPRC009588
Rhodnius prolixus
Kissing bug
Rpro\RPRC014612
Rhodnius prolixus
Kissing bug
Rpro\RPRC003658
Rhodnius prolixus
Kissing bug
Rpro\RPRC002656
Rhodnius prolixus
Kissing bug
Rpro\RPRC003507
Rhodnius prolixus
Kissing bug
Rpro\RPRC000545
Cimex lectularius
Bed bug
Clec\CLEC013405
Cimex lectularius
Bed bug
Clec\CLEC005993
Cimex lectularius
Bed bug
Clec\CLEC006019
Cimex lectularius
Bed bug
Clec\CLEC008446
Cimex lectularius
Bed bug
Clec\CLEC013425
Cimex lectularius
Bed bug
Clec\CLEC013428
Cimex lectularius
Bed bug
Clec\CLEC011675
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007931
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI22564
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI55275
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006915
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003344
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005277
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001792
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005018
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002989
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05767
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_00796
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_15239
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_14342
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07404
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07409
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0A3S )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR002556
Strigamia maritima
European centipede
Smar\SMAR002349
Strigamia maritima
European centipede
Smar\SMAR001835
Strigamia maritima
European centipede
Smar\SMAR013293
Strigamia maritima
European centipede
Smar\SMAR002560
Strigamia maritima
European centipede
Smar\SMAR002261
Ixodes scapularis
Black-legged tick
Isca\ISCW003063
Ixodes scapularis
Black-legged tick
Isca\ISCW002252
Ixodes scapularis
Black-legged tick
Isca\ISCW005940
Ixodes scapularis
Black-legged tick
Isca\ISCW015231
Ixodes scapularis
Black-legged tick
Isca\ISCW001194
Ixodes scapularis
Black-legged tick
Isca\ISCW015232
Ixodes scapularis
Black-legged tick
Isca\ISCW001195
Ixodes scapularis
Black-legged tick
Isca\ISCW002256
Ixodes scapularis
Black-legged tick
Isca\ISCW015224
Ixodes scapularis
Black-legged tick
Isca\ISCW011553
Ixodes scapularis
Black-legged tick
Isca\ISCW019368
Ixodes scapularis
Black-legged tick
Isca\ISCW015228
Ixodes scapularis
Black-legged tick
Isca\ISCW015239
Ixodes scapularis
Black-legged tick
Isca\ISCW015237
Ixodes scapularis
Black-legged tick
Isca\ISCW015226
Ixodes scapularis
Black-legged tick
Isca\ISCW013893
Ixodes scapularis
Black-legged tick
Isca\ISCW002250
Ixodes scapularis
Black-legged tick
Isca\ISCW023546
Ixodes scapularis
Black-legged tick
Isca\ISCW022846
Ixodes scapularis
Black-legged tick
Isca\ISCW003894
Ixodes scapularis
Black-legged tick
Isca\ISCW017055
Ixodes scapularis
Black-legged tick
Isca\ISCW003066
Ixodes scapularis
Black-legged tick
Isca\ISCW017283
Ixodes scapularis
Black-legged tick
Isca\ISCW015230
Ixodes scapularis
Black-legged tick
Isca\ISCW009915
Ixodes scapularis
Black-legged tick
Isca\ISCW019366
Ixodes scapularis
Black-legged tick
Isca\ISCW012517
Ixodes scapularis
Black-legged tick
Isca\ISCW023550
Ixodes scapularis
Black-legged tick
Isca\ISCW015238
Ixodes scapularis
Black-legged tick
Isca\ISCW010899
Ixodes scapularis
Black-legged tick
Isca\ISCW019367
Ixodes scapularis
Black-legged tick
Isca\ISCW019365
Ixodes scapularis
Black-legged tick
Isca\ISCW013892
Ixodes scapularis
Black-legged tick
Isca\ISCW003067
Ixodes scapularis
Black-legged tick
Isca\ISCW010858
Ixodes scapularis
Black-legged tick
Isca\ISCW015056
Ixodes scapularis
Black-legged tick
Isca\ISCW003062
Ixodes scapularis
Black-legged tick
Isca\ISCW003068
Ixodes scapularis
Black-legged tick
Isca\ISCW010886
Ixodes scapularis
Black-legged tick
Isca\ISCW010647
Ixodes scapularis
Black-legged tick
Isca\ISCW015227
Ixodes scapularis
Black-legged tick
Isca\ISCW002253
Ixodes scapularis
Black-legged tick
Isca\ISCW015235
Ixodes scapularis
Black-legged tick
Isca\ISCW015233
Ixodes scapularis
Black-legged tick
Isca\ISCW015236
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74785.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82890.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65625.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82810.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79053.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79273.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79270.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70965.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM73200.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79268.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g06470
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g04190
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g09500
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g08130
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g01270
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g03780
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g09190
Tetranychus urticae
Two-spotted spider mite
Turt\tetur34g00930
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g03200
Tetranychus urticae
Two-spotted spider mite
Turt\tetur28g00900
Tetranychus urticae
Two-spotted spider mite
Turt\tetur15g02930
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g04230
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_324296
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_307269
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_324294
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_48753
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_307239
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_307240
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_322487
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_108808
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_307270
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_214082
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_41788
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_41014
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_307241
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_128564
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0N2V )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hsd17b8
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_024642gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sdr_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Elovl7
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Elovl4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Elovl4_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Dhrs7
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Elovl7L
Ciona intestinalis
Vase tunicate
Cint\elo
Ciona intestinalis
Vase tunicate
Cint\LOC100181604
Ciona intestinalis
Vase tunicate
Cint\LOC100184237
Ciona intestinalis
Vase tunicate
Cint\LOC100184861
Ciona intestinalis
Vase tunicate
Cint\LOC100176701
Ciona intestinalis
Vase tunicate
Cint\LOC100177165
Ciona intestinalis
Vase tunicate
Cint\LOC100180120
Ciona intestinalis
Vase tunicate
Cint\LOC100182495
Gallus gallus
Domestic chicken
Ggal\ELOVL7
Gallus gallus
Domestic chicken
Ggal\DHRS7
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000009714
Gallus gallus
Domestic chicken
Ggal\ELOVL2
Gallus gallus
Domestic chicken
Ggal\ELOVL4
Gallus gallus
Domestic chicken
Ggal\ELOVL5
Gallus gallus
Domestic chicken
Ggal\ELOVL1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (21)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG31522
9 of 10
CG6660
8 of 10
Elo68β
8 of 10
CG18609
7 of 10
Elo68α
7 of 10
eloF
7 of 10
bond
6 of 10
CG5326
6 of 10
CG8534
6 of 10
CG9458
6 of 10
CG9459
6 of 10
CG16904
6 of 10
CG17821
6 of 10
CG30008
6 of 10
CG31141
6 of 10
CG31523
6 of 10
CG33110
6 of 10
sit
6 of 10
Baldspot
5 of 10
CG32071
1 of 10
tea
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 2 )
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ELOVL7; ELOVL fatty acid elongase 7
    15 of 15
    614451
        ELOVL1; ELOVL fatty acid elongase 1
        11 of 15
        611813
           
          ELOVL2; ELOVL fatty acid elongase 2
          5 of 15
          611814
              ELOVL4; ELOVL fatty acid elongase 4
              5 of 15
              605512
              ELOVL5; ELOVL fatty acid elongase 5
              4 of 15
              611805
              Functional Complementation Data
              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
              Interactions
              Summary of Physical Interactions
              esyN Network Diagram
              Interactions Browser
              Summary of Genetic Interactions
              esyN Network Diagram
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              External Data
              Linkouts
              DroID - A comprehensive database of gene and protein interactions.
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              Pathways
              Signaling Pathways (FlyBase)
              Metabolic Pathways
              External Data
              Linkouts
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Genomic Location and Detailed Mapping Data
              Chromosome (arm)
              3R
              Recombination map
              3-48
              Cytogenetic map
              84E6-84E7
              Sequence location
              3R:7,981,817..7,995,852 [-]
              FlyBase Computed Cytological Location
              Cytogenetic map
              Evidence for location
              84E6-84E7
              Limits computationally determined from genome sequence between P{EP}EP3060EP3060 and P{PZ}grn05930
              Experimentally Determined Cytological Location
              Cytogenetic map
              Notes
              References
              Experimentally Determined Recombination Data
              Location

              3-48

              (FlyBase, 2016)

              3-44.7

              (Comeron et al., 2012)
              Left of (cM)
              Right of (cM)
              Notes
              Stocks and Reagents
              Stocks (5)
              Genomic Clones (26)
              cDNA Clones (25)
               

              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

              cDNA clones, fully sequenced
              BDGP DGC clones
              Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of

              Source for identity of: Elovl7 CG2781

              (Gordon et al., 2018)
              Source for database merge of
              Additional comments
              Other Comments
              Origin and Etymology
              Discoverer
              Etymology

              FlyBase curator comment: Designated 'ELOVL' in the paper but named as 'Elovl7' in FlyBase because there are 20 D. melanogaster genes encoding fatty acid elongases (ELOVLs), and this one is most similar to human ELOVL7.

              (Gordon et al., 2018)
              Identification
              External Crossreferences and Linkouts ( 31 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              modMine - A data warehouse for the modENCODE project
              Linkouts
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Synonyms and Secondary IDs (6)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (48)