FB2026_03 , released September 17, 2026
Allele: Dmel\Tm1delC
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General Information
Symbol
Dmel\Tm1delC
Species
D. melanogaster
Name
FlyBase ID
FBal0324936
Feature type
allele
Associated gene
Dmel\Tm1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Veeranan-Karmegam et al., 2016)
Mutagen
CRISPR/Cas9
(Veeranan-Karmegam et al., 2016)
Progenitor genotype
Cytology
Description

A small deletion between the 5'UTR and the first exon of the Tm1C and Tm1I isoforms removes the initiating ATG codon and leads to several premature stop codons, resulting in an isoformC-specific null.

(Veeranan-Karmegam et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:15,288,340..15,288,954 [+]
Comment:

A 615 bp deletion that removes part of the 5' UTR and the start of the coding sequence of the Tm1-PC and Tm1-PI isoforms.

(Gonsalvez, 2017.2.21)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Tm1delC homozygous mutants are semi-viable with about 20% of them dying during pupation and display localization defects of both the osk mRNA (the mRNA delocalizes from the posterior oocyte cortex, however its ability to form oligomeric particles is not affected) and the vas protein in egg chambers. Localization of the oocyte nucleus, the grk mRNA or the Khc and Dhc64C proteins is not perturbed.

      (Veeranan-Karmegam et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Tm1delC is rescued by Tm1vas.C.EGFP

      (Veeranan-Karmegam et al., 2016)
      Comments

      Expression of Tm1vas.C.T:Avic\GFP-EGFP completely restores the normal posterior localization of the osk mRNA in the Tm1delC mutant egg chambers.

      (Veeranan-Karmegam et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Tm1delC
      (Gonsalvez, 2017.2.21)
      tm1_delC
      (Veeranan-Karmegam et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)