FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Atg16Tag:HA
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General Information
Symbol
Dmel\Atg16Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0325054
Feature type
allele
Associated gene
Dmel\Atg16
Associated Insertion(s)
Carried in Construct
P{Atg16-HA}
Key Links
Transgenic product class
wild_type
(Varga et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Varga et al., 2016)
Mutagen
in vitro construct
(Varga et al., 2016)
Progenitor genotype
Carried in construct
P{Atg16-HA}
Cytology
Description

8,206bp region of Atg16 (including promoter), tagged with three copies of Tag:HA.

(Varga et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
Atg16
Encoded product / tool
Atg16
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      epitope tag
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      neurosecretory neuron of adult pars lateralis
      (Varga et al., 2016)
      Additional Information
      Statement
      Reference

      Atg16-HA is highly expressed in neurosecretory cells located in the pars lateralis in the adult brain that also express the neuropeptide Crz.

      (Varga et al., 2016)
       
      Marker for
      Reflects expression of
      Atg16
      (Varga et al., 2016)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Atg16Tag:HA rescues Atg16d67

      (Varga et al., 2016)
      Comments

      The abrogated formation of acidic lysosomes in fat body cells in Atg16d67 homozygous third instar larvae as well as the accumulation of protein aggregates in brain neurons in adult flies, their reduced climbing ability and shorter lifespan can be rescued by combination with Atg16T:Ivir\HA1.

      (Varga et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Atg16T:Ivir\HA1
      Atg16Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (3)