FlyBase Allele Report: Dmel\Ilp8[KO]

General Information

Symbol

Dmel\Ilp8^KO

Species

D. melanogaster

Name

FlyBase ID

FBal0325081

Feature type

allele

Associated gene

Dmel\Ilp8

Associated Insertion(s)

Carried in Construct

Also Known As

dilp8^KO

Key Links

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Boone et al., 2016)

Mutagen

CRISPR/Cas9

(Boone et al., 2016)

ends-out gene targeting

(Boone et al., 2016)

cre recombinase

(Boone et al., 2016)

Progenitor genotype

Cytology

Description

Knockout mutation.

(Boone et al., 2016)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body size | P-stage

(Heredia et al., 2021)

Phenotype Manifest In

wing blade

(Boone et al., 2016)

wing blade (with Ilp8^PFΔ123)

(Boone et al., 2016)

Detailed Description

Statement

Reference

Ilp8^KO homozygous adults display increased level of fluctuating asymmetry in the size of their wings.

(Boone et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Ilp8^KO/Df(3L)Ilp8^Ex is a suppressor of homeotic | adult stage phenotype of Scer\GAL4^ey.PH, wge^UAS.Tag:FLAG

(Nemoto et al., 2023)

Ilp8^KO/Df(3L)Ilp8^Ex is a suppressor of visible | adult stage phenotype of Scer\GAL4^ey.PH, wge^UAS.Tag:FLAG

(Nemoto et al., 2023)

Ilp8^KO/Ilp8^KO is a suppressor of homeotic | adult stage phenotype of Scer\GAL4^ey.PH, wge^UAS.Tag:HA

(Nemoto et al., 2023)

Ilp8^KO/Ilp8^KO is a suppressor of visible | adult stage phenotype of Scer\GAL4^ey.PH, wge^UAS.Tag:HA

(Nemoto et al., 2023)

Ilp8^KO is a suppressor | partially of abnormal developmental rate phenotype of BacA\p35^UAS.cHa, Bub3^GD9924, Scer\GAL4^ap-md544

(Romão et al., 2021)

NOT Suppressor of

Statement

Reference

Ilp8^KO/Ilp8^KO is a non-suppressor of decreased size | adult stage phenotype of Scer\GAL4^ey.PH, wge^UAS.Tag:HA

(Nemoto et al., 2023)

Other

Statement

Reference

Ilp8^KO, Ilp8^UAS.cNa, Scer\GAL4^ey.PH, wge^UAS.Tag:HA has visible | adult stage phenotype

(Nemoto et al., 2023)

Ilp8^KO, Ilp8^UAS.cNa, Scer\GAL4^ey.PH, wge^UAS.Tag:HA has homeotic | adult stage phenotype

(Nemoto et al., 2023)

Ilp8^KO, Scer\GAL4^ey.PH, wge^UAS.Tag:HA has decreased size | larval stage phenotype

(Nemoto et al., 2023)

Phenotype Manifest In

Suppressor of

Statement

Reference

Ilp8^KO/Df(3L)Ilp8^Ex is a suppressor of eye phenotype of Scer\GAL4^ey.PH, wge^UAS.Tag:FLAG

(Nemoto et al., 2023)

Ilp8^KO/Ilp8^KO is a suppressor | partially of eye phenotype of Scer\GAL4^ey.PH, wge^UAS.Tag:HA

(Nemoto et al., 2023)

Other

Statement

Reference

Ilp8^KO, Ilp8^UAS.cNa, Scer\GAL4^ey.PH, wge^UAS.Tag:HA has eye phenotype

(Nemoto et al., 2023)

Ilp8^KO, Scer\GAL4^ey.PH, wge^UAS.Tag:HA has eye disc | larval stage phenotype

(Nemoto et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Ilp8^KO

dilp8^KO

(Volonté et al., 2026, Nemoto et al., 2023, Heredia et al., 2021, Romão et al., 2021)

dilp8KO

(Boone et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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