FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\LamCUAS.cLa
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General Information
Symbol
Dmel\LamCUAS.cLa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Li
FlyBase ID
FBal0325874
Feature type
allele
Associated gene
Dmel\LamC
Associated Insertion(s)
Carried in Construct
P{UAS-LamC.L}
Key Links
Transgenic product class
cDNA
(Li et al., 2016)
wild_type
(Li et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Li et al., 2016)
wild_type
(Li et al., 2016)
Mutagen
in vitro construct
(Li et al., 2016)
Progenitor genotype
Carried in construct
P{UAS-LamC.L}
Cytology
Description

UASt regulatory sequences drive expression of LamC cDNA (DGRC LD31805 clone).

(Li et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
LamC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of LamCScer\UAS.cLa under the control of Scer\GAL4Mhc.PW in LamCunspecified heterozygotes results in no defects in dorsal longitudinal indirect flight muscles - i.e. defects in myofibril morphology, sarcomere organization, mitochondria morphology, relative mitochondria volume or electron density of mitochondria in electron microscopy images, or the presence of abnormal cytoplasmic polyubiquitin aggregates - and in no obvious flight defects, as shown by insignificant differences in landing height, as compared to controls.

      The expression of LamCScer\UAS.cLa under the control of Scer\GAL4BG487 in either LamCunspecified heterozygotes or LamCEX265/LamCEX296 transheterozygotes does not induce significant abnormal nuclear lamina blebs in third instar larval muscles 6 and 7, as compared to controls.

      (Li et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4Mhc.PW/LamCUAS.cLa rescues LamCEX296/LamCEX265

      (Li et al., 2016)
      Comments

      The expression of LamCScer\UAS.cLa under the control of Scer\GAL4Mhc.PW suppresses the increased proportion of 'ghost' neuromuscular junctions observed in LamCEX265/LamCEX296 transheterozygous third instar larval muscles 6 and 7.

      (Li et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      LamCScer\UAS.cLa
      LamCUAS.cLa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Li
      Secondary FlyBase IDs
        References (1)