FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\su(Hw)M393
Open Close
General Information
Symbol
Dmel\su(Hw)M393
Species
D. melanogaster
Name
FlyBase ID
FBal0326576
Feature type
allele
Associated gene
Dmel\su(Hw)
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Baxley et al., 2017)
Progenitor genotype
Cytology
Description

Amino acid replacement: C350S.

(Baxley et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:14,306,842..14,306,842 [-]
Nucleotide change:

T14306842A

Amino acid change:

C350S | su(Hw)-PA; C350S | su(Hw)-PB; C350S | su(Hw)-PC

Reported amino acid change:

C350S

Comment:

A nucleotide change at the first or second position of the Cys codon leads to a Ser mutation (base change unspecified). Change is either TGC to AGC or TGC to TCC.

(Baxley et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      su(Hw)M393 mutants are female sterile but retain the gypsy insulator function (assayed through body, wing and bristle phenotypes induced by mutations in the y, ct and f genes).

      (Baxley et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      su(Hw)A460

      (Baxley et al., 2017)

      su(Hw)7

      (Baxley et al., 2017)
      Partially complements

      su(Hw)e04061

      (Baxley et al., 2017)

      su(Hw)2

      (Baxley et al., 2017)

      su(Hw)V

      (Baxley et al., 2017)

      su(Hw)E8

      (Baxley et al., 2017)
      Comments

      su(Hw)M393 allele partially complements each of the following alleles: su(Hw)V, su(Hw)2, su(Hw)e04061 or su(Hw)E8 as it rescues their loss of gypsy insulator function (assayed through body, wing and bristle phenotypes induced by mutations in the y, ct and f genes) but it fails to restore female fertility and it also complements the separation-of-function alleles su(Hw)7 and su(Hw)A460 that only affect the gypsy insulator function (and thus the transheterozygous flies are both fertile and have normal insulator function).

      su(Hw)A460 does, whereas su(Hw)A2663 does not, complement su(Hw)M393, a separation-of-function allele that only impairs female fertility.

      (Baxley et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      M4
      (Baxley et al., 2017)
      su(Hw)M393
      (Baxley et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)