FB2026_02 , released June 18, 2026
Allele: Dmel\NPFSK2
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General Information
Symbol
Dmel\NPFSK2
Species
D. melanogaster
Name
FlyBase ID
FBal0327363
Feature type
allele
Associated gene
Dmel\NPF
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Chung et al., 2017)
Mutagen
CRISPR/Cas9
(Chung et al., 2017)
Progenitor genotype
Cytology
Description

11bp deletion in the NPF open reading frame causes a frameshift that truncates most of the ORF.

(Chung et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:16,610,832..16,610,842 [+]
Comment:

An 11 bp deletion near the amino-terminal end of the NPF coding sequence leads to a frameshift and early translation termination.

(Chung et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Thermogenetic activation (using TrpA1Scer\UAS.cUa at 29[o]C) of Scer\GAL4NPF.1 neurons in a NPFSK2/NPFSK2 background does not significantly affect sleep compared to controls (and these flies sleep significantly more than Scer\GAL4NPF.1>TrpA1Scer\UAS.cUa flies at 29[o]C). NPFSK2/NPFSK2 mutants do not exhibit a significant increase in sleep amount compared to controls. NPFSK2/NPFSK2 mutants do not exhibit the significant starvation-induced sleep loss that is seen in control flies.

      (Chung et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      NPFSK2
      (Chung et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)