FlyBase Allele Report: Dmel\p53[TM3]

General Information

Symbol

Dmel\p53^TM3

Species

D. melanogaster

Name

FlyBase ID

FBal0328062

Feature type

allele

Associated gene

Dmel\p53

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Miller et al., 2020)

loss of function allele

(D'Brot et al., 2017)

Mutagen

Progenitor genotype

Caused by aberration

In(3LR)TM3-3

Cytology

Description

Inversion breakpoint (94D10 breakpoint of In(3LR)TM3a) within p53. The 5' end of this breakpoint corresponds to 3R:23050763 and the 3' end corresponds to 3R:23050764 (release 6 coordinates).

(Miller et al., 2016)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cancer

CEA with p53^-ns, Hsap\TP53^R175H

(D'Brot et al., 2017)

CEA with p53^-ns, Hsap\TP53^G245S

(D'Brot et al., 2017)

CEA with p53^-ns, Hsap\TP53^R248Q

(D'Brot et al., 2017)

CEA with p53^-ns, Hsap\TP53^R273C

(D'Brot et al., 2017)

CEA with p53^-ns, Hsap\TP53^R273H

(D'Brot et al., 2017)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell death | embryonic stage | conditional (with p53^-ns)

(D'Brot et al., 2017)

decreased cell death | larval stage | conditional (with p53^-ns)

(D'Brot et al., 2017)

Phenotype Manifest In

wing disc | embryonic stage | conditional (with p53^-ns)

(D'Brot et al., 2017)

wing disc | larval stage | conditional (with p53^-ns)

(D'Brot et al., 2017)

Detailed Description

Statement

Reference

γ-irradiated p53^-ns/p53^TM3 embryos and larval wing discs (the Tm3, Sb balancer has an inversion break point at the p53 gene) fail to show the expected increase in apoptosis.

(D'Brot et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

p53^TM3/p53^-ns has decreased cell death | larval stage | conditional phenotype, suppressible by Hsap\TP53^WT.1

(D'Brot et al., 2017)

p53^TM3/p53^-ns has decreased cell death | embryonic stage | conditional phenotype, suppressible by Hsap\TP53^WT.1