FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\RELAAD.R59E08
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General Information
Symbol
Hsap\RELAAD.R59E08
Species
H. sapiens
Name
FlyBase ID
FBal0329095
Feature type
allele
Associated gene
Hsap\RELA
Associated Insertion(s)
Carried in Construct
P{R59E08-p65.AD}
Also Known As
R59E08-AD, R59E08-p65ADZp
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Rubin Laboratory at Janelia Farm, 2017)
Progenitor genotype
Carried in construct
P{R59E08-p65.AD}
Cytology
Description

The GMR59E08 enhancer fragment followed by the Drosophila synthetic core promoter (DSCP) is fused upstream of the p65(AD)::Zip+ hemidriver (component of a 'split driver' system, contains the p65 activation domain).

(Rubin Laboratory at Janelia Farm, 2017)
Allele components
Component
Use(s)
Regulatory region(s)
GMR59E08
Encoded product / tool
p65(AD)::Zip+
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      T4 neuron

      Comment: when combined with P{R42F06-GAL4.DBD}

      when combined with P{R42F06-GAL4.DBD} (combination referred to as 'SS00324')

      when combined with P{R42F06-GAL4.DBD} (combination referred to as 'T4/T5')

      when combined with P{R42F06-GAL4.DBD} (combination referred to as 'T4/T5-SplitGal4')

      when combined with P{R59E08-GAL4.DBD}

      (Tanaka and Clark, 2022, Drews et al., 2020, Hörmann et al., 2020, Keleş et al., 2020, Klapoetke et al., 2017, Strother et al., 2017, Bahl et al., 2015)
      T5 neuron

      Comment: when combined with P{R42F06-GAL4.DBD}

      when combined with P{R42F06-GAL4.DBD} (combination referred to as 'SS00324')

      when combined with P{R42F06-GAL4.DBD} (combination referred to as 'T4/T5')

      when combined with P{R42F06-GAL4.DBD} (combination referred to as 'T4/T5-SplitGal4')

      when combined with P{R59E08-GAL4.DBD}

      (Tanaka and Clark, 2022, Drews et al., 2020, Hörmann et al., 2020, Keleş et al., 2020, Klapoetke et al., 2017, Strother et al., 2017, Bahl et al., 2015)
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Inhibition (using Ctet\tetXTNT-LC.UAS) of neurons targeted by the split-GAL4 pair of Scer\GAL4DBD.R42F06 and Hsap\RELAAD.R59E08 reduces the ability of adult males to orient towards and remain close to a female, compared to controls; they also lose the bias seen in controls to extend the wing closest to, rather than furthest from, the female; following of females and wing extensions, but not copulation, are significantly reduced, compared to controls.

      (Ribeiro et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\RELAAD.R59E08.T:Zzzz\Zip+
      Hsap\RELAAD.R59E08
      Name Synonyms
      Secondary FlyBase IDs
        References (25)