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Citation
Keleş, M.F., Hardcastle, B.J., Städele, C., Xiao, Q., Frye, M.A. (2020). Inhibitory Interactions and Columnar Inputs to an Object Motion Detector in Drosophila.  Cell Rep. 30(7): 2115--2124.e5.
FlyBase ID
FBrf0244891
Publication Type
Research paper
Abstract

The direction-selective T4/T5 cells innervate optic-flow processing projection neurons in the lobula plate of the fly that mediate the visual control of locomotion. In the lobula, visual projection neurons coordinate complex behavioral responses to visual features, however, the input circuitry and computations that bestow their feature-detecting properties are less clear. Here, we study a highly specialized small object motion detector, LC11, and demonstrate that its responses are suppressed by local background motion. We show that LC11 expresses GABA-A receptors that serve to sculpt responses to small objects but are not responsible for the rejection of background motion. Instead, LC11 is innervated by columnar T2 and T3 neurons that are themselves highly sensitive to small static or moving objects, insensitive to wide-field motion and, unlike T4/T5, respond to both ON and OFF luminance steps.

PubMed ID
PubMed Central ID
PMC7210872 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell Rep.
    Title
    Cell reports
    ISBN/ISSN
    2211-1247
    Data From Reference
    Alleles (43)
    Genes (16)
    Insertions (9)
    Transgenic Constructs (27)
    Transcripts (24)