FlyBase Allele Report: Hsap\RELA[AD.R78H05]

General Information

Symbol

Hsap\RELA^AD.R78H05

Species

H. sapiens

Name

FlyBase ID

FBal0329303

Feature type

allele

Associated gene

Hsap\RELA

Associated Insertion(s)

Carried in Construct

P{R78H05-p65.AD}

PBac{R78H05-p65.AD}

Also Known As

R78H05-p65.AD

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Rubin Laboratory at Janelia Farm, 2017)

Progenitor genotype

Carried in construct

P{R78H05-p65.AD}

PBac{R78H05-p65.AD}

Cytology

Description

The GMR78H05 enhancer fragment followed by the Drosophila synthetic core promoter (DSCP) is fused upstream of the p65(AD)::Zip+ hemidriver (component of a 'split driver' system, contains the p65 activation domain).

(Rubin Laboratory at Janelia Farm, 2017)

Allele components

Component

Use(s)

Regulatory region(s)

GMR78H05

Encoded product / tool

p65(AD)::Zip+

split driver - transcription activation fragment

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage, with Scer\GAL4^DBD.R31F09, Ten-m^VSH330540

(Xu et al., 2024)

Phenotype Manifest In

adult antennal lobe, with Scer\GAL4^DBD.R31F09, Ten-m^VSH330540

(Xu et al., 2024)

adult olfactory receptor neuron Or88a, with Scer\GAL4^DBD.R31F09, Ten-m^VSH330540

(Xu et al., 2024)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Hsap\RELA^AD.R78H05, Scer\GAL4^DBD.R31F09, Ten-m^VSH330540 has abnormal neuroanatomy | adult stage phenotype, suppressible by Hsap\RELA^AD.R78H05/RhoGAP100F^RNAi.UAS.cBa, Scer\GAL4^DBD.R31F09

(Xu et al., 2024)

Hsap\RELA^AD.R78H05, Scer\GAL4^DBD.R31F09, Ten-m^VSH330540 has abnormal neuroanatomy | adult stage phenotype, suppressible by Hsap\RELA^AD.R78H05/Rac1^UAS.cWa, Scer\GAL4^DBD.R31F09

(Xu et al., 2024)

Suppressor of

Statement

Reference

Scer\GAL4^DBD.R31F09, Hsap\RELA^AD.R78H05/RhoGAP100F^RNAi.UAS.cBa is a suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\RELA^AD.R78H05, Scer\GAL4^DBD.R31F09, Ten-m^VSH330540

(Xu et al., 2024)

Scer\GAL4^DBD.R31F09, Hsap\RELA^AD.R78H05/Rac1^UAS.cWa is a suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\RELA^AD.R78H05, Scer\GAL4^DBD.R31F09, Ten-m^VSH330540

(Xu et al., 2024)

Phenotype Manifest In

Suppressed by

Statement

Reference

Hsap\RELA^AD.R78H05, Scer\GAL4^DBD.R31F09, Ten-m^VSH330540 has adult olfactory receptor neuron Or88a phenotype, suppressible by Hsap\RELA^AD.R78H05/Rac1^UAS.cWa, Scer\GAL4^DBD.R31F09

(Xu et al., 2024)

Hsap\RELA^AD.R78H05, Scer\GAL4^DBD.R31F09, Ten-m^VSH330540 has adult antennal lobe phenotype, suppressible by Hsap\RELA^AD.R78H05/Rac1^UAS.cWa, Scer\GAL4^DBD.R31F09

(Xu et al., 2024)

Hsap\RELA^AD.R78H05, Scer\GAL4^DBD.R31F09, Ten-m^VSH330540 has adult olfactory receptor neuron Or88a phenotype, suppressible by Hsap\RELA^AD.R78H05/RhoGAP100F^RNAi.UAS.cBa, Scer\GAL4^DBD.R31F09

(Xu et al., 2024)

Hsap\RELA^AD.R78H05, Scer\GAL4^DBD.R31F09, Ten-m^VSH330540 has adult antennal lobe phenotype, suppressible by Hsap\RELA^AD.R78H05/RhoGAP100F^RNAi.UAS.cBa, Scer\GAL4^DBD.R31F09

(Xu et al., 2024)

Suppressor of

Statement

Reference

Scer\GAL4^DBD.R31F09, Hsap\RELA^AD.R78H05/Rac1^UAS.cWa is a suppressor of adult olfactory receptor neuron Or88a phenotype of Hsap\RELA^AD.R78H05, Scer\GAL4^DBD.R31F09, Ten-m^VSH330540

(Xu et al., 2024)

Scer\GAL4^DBD.R31F09, Hsap\RELA^AD.R78H05/Rac1^UAS.cWa is a suppressor of adult antennal lobe phenotype of Hsap\RELA^AD.R78H05, Scer\GAL4^DBD.R31F09, Ten-m^VSH330540

(Xu et al., 2024)

Scer\GAL4^DBD.R31F09, Hsap\RELA^AD.R78H05/RhoGAP100F^RNAi.UAS.cBa is a suppressor of adult olfactory receptor neuron Or88a phenotype of Hsap\RELA^AD.R78H05, Scer\GAL4^DBD.R31F09, Ten-m^VSH330540

(Xu et al., 2024)

Scer\GAL4^DBD.R31F09, Hsap\RELA^AD.R78H05/RhoGAP100F^RNAi.UAS.cBa is a suppressor of adult antennal lobe phenotype of Hsap\RELA^AD.R78H05, Scer\GAL4^DBD.R31F09, Ten-m^VSH330540

(Xu et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Hsap\RELA^AD.R78H05, Scer\GAL4^DBD.R31F09, Ten-m^{UAS.RR.Tag:V5} rescues Ten-m^VSH330540

(Xu et al., 2024)

Comments

Images (0)

Mutant

Wild-type

Stocks (9)

Bloomington

601815

w¹¹¹⁸; PBac{R78H05-p65.AD}VK00027

70814

w¹¹¹⁸; P{R78H05-p65.AD}attP40; MKRS/TM6B, Tb¹

87852

w¹¹¹⁸; P{R78H05-p65.AD}attP40; P{R81C11-GAL4.DBD}attP2

88062

w¹¹¹⁸; P{R78H05-p65.AD}attP40; P{R31H09-GAL4.DBD}attP2

89371

w¹¹¹⁸; P{R54B01-GAL4.DBD}attP2 PBac{R78H05-p65.AD}VK00027

87265

w¹¹¹⁸; P{VT050300-GAL4.DBD}attP2 PBac{R78H05-p65.AD}VK00027

606889

w^*; P{R78H05-p65.AD}attP40; P{R31F09-GAL4.DBD}attP2/TM3, Sb¹

606890

w^*; P{hsFLP}12, P{tub-QS.P}F P{neoFRT}19A; P{R20D10-QF2.L}JK22C P{QUAS-mtdTomato-3xHA}14/CyO, P{Wee-P.ph0}2; M{R31F09-lexA.DBD}ZH-86Fb PBac{R78H05-p65.AD}VK00027/TM2

607345

P{UAS-Dcr-2.D}1, w^* P{5xQUAS-jGCaMP8m}attP18; P{R82E01-QF2.L}JK22C P{20XUAS-CsChrimson.mCherry}su(Hw)attP5; P{R31F09-GAL4.DBD}attP2 PBac{5xQUAS-jGCaMP8m}VK00005 PBac{R78H05-p65.AD}VK00027

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\RELA^{AD.R78H05.T:Zzzz\Zip+}

Hsap\RELA^AD.R78H05

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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