FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Scer\GAL4NP1562
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General Information
Symbol
Scer\GAL4NP1562
Species
S. cerevisiae
Name
FlyBase ID
FBal0337161
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
P{GawB}NP1562
Carried in Construct
Also Known As
NP1562-GAL4
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GawB}NP1562
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    P{GawB}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        distribution deduced from reporter (Gal4 UAS)
        Stage
        Tissue/Position (including subcellular localization)
        Reference
        adult stage
        adult brain | restricted
        (Kain and Dahanukar, 2015)
        adult gnathal ganglion | restricted
        (Kain and Dahanukar, 2015)
        antennal mechanosensory and motor center | restricted
        (Kain and Dahanukar, 2015)
        sweet gustatory projection neuron
        (Kain and Dahanukar, 2015)
        Additional Information
        Statement
        Reference

        ScerGAL4NP1562 drives expression in three clusters of 19-22 neurons in total in the adult brain; neurons that are in and around the antennal mechanosensory and motor center including the sweet gustatory projection neurons, and two clusters of neurons in and around the dorsal anterior and ventral parts of the adult gnathal ganglion.

        (Kain and Dahanukar, 2015)
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Inhibition (using Ctet\TeTxLCTNT.UAS or Hsap\KCNJ2UAS.EGFP) of Scer\GAL4NP1562 neurons, in combination with a Gal80[ts] transgene to restrict expression to the adult stage, significantly reduces sucrose feeding across a range of concentrations, compared to controls; proboscis extension responses to tarsal sucrose stimulation are also significantly reduced when Ctet\TeTxLCTNT.UAS is used.

        Thermogenetic activation (using TrpA1UAS.(B).cKa at 32[o]C) of Scer\GAL4NP1562 neurons induces a high frequency of proboscis extension, compared to controls; activation (at 30[o]C) does not affect sucrose feeding, compared to controls.

        Adult males in which clones (generated using hs-FLP during larval stage) of Scer\GAL4NP1562 neurons are thermogenetically activated (using TrpA1UAS.(B).cKa at 32[o]C) always have an induction of proboscis extension, compared to controls, when the sweet gustatory projection neurons (cluster I) are activated; this is not the case for other types of Scer\GAL4NP1562 neuron.

        (Kain and Dahanukar, 2015)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Scer\GAL4NP1562
        Name Synonyms
        Secondary FlyBase IDs
          References (2)