FB2026_02 , released June 18, 2026
Allele: Dmel\RpS12G97D.2kb
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General Information
Symbol
Dmel\RpS12G97D.2kb
Species
D. melanogaster
Name
FlyBase ID
FBal0337982
Feature type
allele
Associated gene
Dmel\RpS12
Associated Insertion(s)
Carried in Construct
PBac{RpS12.2kb.G97D}
Key Links
Transgenic product class
missense_variant
(Kale et al., 2018)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Kale et al., 2018)
Mutagen
in vitro construct
(Kale et al., 2018)
Progenitor genotype
Carried in construct
PBac{RpS12.2kb.G97D}
Cytology
Description

An approximately 2kb genomic fragment containing the RpS12 locus bearing the RpS12G97D mutation, and including the snoRNA:Me28S-A774a and snoRNA:Me28S-A774b in its introns.

(Kale et al., 2018)
Allele components
Component
Use(s)
Regulatory region(s)
RpS12
Encoded product / tool
RpS12
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Larval wing disc clones bearing two copies of RpS12G97D.2kb do not compete with neighboring wild-type control clones, as shown by their comparable sizes.

      (Kale et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      RpS12G97D.2kb is a non-enhancer of wing disc | somatic clone phenotype of M(2)56FH

      (Kale et al., 2018)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Df(1)su(s)R194-heterozygous clones in the larval eye disc are outcompeted by neighboring clones that also harbor RpL36+t4); this phenotype is suppressed by homozygosity for RpS12G97D in combination with two copies of RpS12G97D.2kb, but not by two copies of RpS12G97D.2kb alone.

      The following genotypes exhibit a minute-like developmental delay phenotype as compared to controls: Df(1)su(s)R194/+, RpS12s2783/RpS12s2783, RpS12G97D.2kb.

      In Df(2R)BSC865-heterozygous or M(2)56FH-heterozygous larval wing discs, clones bearing two copies of RpS12G97D.2kb do not compete with otherwise wild-type neighboring clones, as shown by their comparable clone sizes. The increased cell death observed in M(2)56FH-heterozygous larval wing discs is not enhanced within clones bearing two copies of RpS12G97D.2kb.

      (Kale et al., 2018)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      RpS12G97D.2kb rescues RpS12s2783

      (Kale et al., 2018)
      Comments

      Two copies of RpS12G97D.2kb rescue the cell lethality RpS12s2783-homozygous clones in larval wing discs.

      (Kale et al., 2018)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      RpS12G97D.2kb
      Name Synonyms
      Secondary FlyBase IDs
        References (1)