FlyBase Allele Report: Dmel\nom[557]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\nom⁵⁵⁷

General Information

Symbol

Dmel\nom⁵⁵⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0338603

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Uryu et al., 2018)

Mutagen

(Uryu et al., 2018)

Progenitor genotype

Cytology

Description

An indel mutation, resulting in a nom protein that is four amino acids longer than the wild-type protein, but lacks the first zinc finger domain entirely and part of the second zinc finger domain with an in-frame inappropriate amino acid stretch.

(Uryu et al., 2018)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

3R:8,723,847..8,724,017 [+]

Comment:

A 171 bp deletion that removes 104 bp from the 3' end of exon two and 67

bp from the 5' end of intron two. This causes a read-through of intron sequences and the addition of 41 novel amino acids to the protein. The first zinc finger domain is completely removed as well as the first cysteine of the second zinc finger domain.

(Uryu et al., 2018)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | second instar larval stage

(Uryu et al., 2018)

abnormal developmental rate | second instar larval stage (with Df(3R)BSC197)

(Uryu et al., 2018)

abnormal developmental rate | second instar larval stage (with nom³³)

(Uryu et al., 2018)

abnormal developmental rate | second instar larval stage (with nom⁶⁰)

(Uryu et al., 2018)

increased body size | second instar larval stage

(Uryu et al., 2018)

increased body size | second instar larval stage (with Df(3R)BSC197)

(Uryu et al., 2018)

lethal - all die before end of second instar larval stage

(Uryu et al., 2018)

lethal - all die before end of second instar larval stage (with Df(3R)BSC197)

(Uryu et al., 2018)

lethal - all die before end of second instar larval stage (with nom³³)

(Uryu et al., 2018)

lethal - all die before end of second instar larval stage (with nom⁶⁰)

(Uryu et al., 2018)

some die during first instar larval stage

(Uryu et al., 2018)

some die during first instar larval stage (with nom³³)

(Uryu et al., 2018)

some die during first instar larval stage (with nom⁶⁰)

(Uryu et al., 2018)

some die during second instar larval stage

(Uryu et al., 2018)

some die during second instar larval stage (with nom³³)

(Uryu et al., 2018)

some die during second instar larval stage (with nom⁶⁰)

(Uryu et al., 2018)

viable (with nom³³)

(Uryu et al., 2018)

viable (with nom⁶⁰)

(Uryu et al., 2018)

Phenotype Manifest In

Detailed Description

Statement

Reference

nom⁵⁵⁷/nom⁵⁵⁷ and nom⁵⁵⁷/Df(3R)BSC197 individuals arrest development at the second instar larval stage, with the larvae being larger than controls.

(Uryu et al., 2018)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

nom⁵⁵⁷ has lethal - all die before end of second instar larval stage phenotype, suppressible by nvd^UAS.cUa/Scer\GAL4^phtm.PO

(Uryu et al., 2018)

nom⁵⁵⁷/nom⁶⁰ has lethal - all die before end of second instar larval stage phenotype, suppressible by nvd^UAS.cUa/Scer\GAL4^phtm.PO

(Uryu et al., 2018)

nom⁵⁵⁷/nom³³ has lethal - all die before end of second instar larval stage phenotype, suppressible by nvd^UAS.cUa/Scer\GAL4^phtm.PO

(Uryu et al., 2018)

Other

Statement

Reference

Scer\GAL4^phtm.PO, nom⁵⁵⁷, nvd^UAS.cUa has viable phenotype

(Uryu et al., 2018)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

nom⁵⁵⁷

sean⁵⁵⁷

(Uryu et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections