FlyBase Allele Report: Hsap\IRF2BPL[UAS.cBa]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Hsap\IRF2BPL^UAS.cBa

General Information

Symbol

Hsap\IRF2BPL^UAS.cBa

Species

H. sapiens

Name

FlyBase ID

FBal0339991

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

PBac{UAS-hIRF2BPL.B}

Also Known As

UAS-IRF2BPL

Key Links

Transgenic product class

(Celniker and Bellen, 2017-)

(Celniker and Bellen, 2017-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Celniker and Bellen, 2017-)

(Celniker and Bellen, 2017-)

Mutagen

in vitro construct

(Celniker and Bellen, 2017-)

Progenitor genotype

Carried in construct

PBac{UAS-hIRF2BPL.B}

Cytology

Description

UASt regulatory sequences drive expression of the Hsap\IRF2BPL open reading frame. The endogenous stop codon is present, thus even though three copies of the Tag:HA tag are present downstream of the ORF, they are not expected to form part of the translated protein. The ORF corresponds to Ensembl transcript ENST00000238647.4.

(Celniker and Bellen, 2017-)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures

CEC

(Marcogliese et al., 2022)

CEA

(Marcogliese et al., 2022)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures

is ameliorated by CkIα^JF01792

(Marcogliese et al., 2022)

is ameliorated by dsh^UAS.Tag:MYC

(Marcogliese et al., 2022)

is ameliorated by wg^{UAS.cHa.Tag:HA}

(Marcogliese et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | adult stage, with Scer\GAL4^nub-AC-62

(Marcogliese et al., 2022)

Phenotype Manifest In

wing margin, with Scer\GAL4^nub-AC-62

(Marcogliese et al., 2022)

Detailed Description

Statement

Reference

The expression of Hsap\IRF2BPL^UAS.cBa under the control of Scer\GAL4^nub-AC-62 induces wing margin loss.

(Marcogliese et al., 2022)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Hsap\IRF2BPL^UAS.cBa, Scer\GAL4^nub-AC-62 has visible | adult stage phenotype, suppressible by wg^{UAS.cHa.Tag:HA}, Scer\GAL4^nub-AC-62

(Marcogliese et al., 2022)

Hsap\IRF2BPL^UAS.cBa, Scer\GAL4^nub-AC-62 has visible | adult stage phenotype, suppressible | partially by CkIα^JF01792, Scer\GAL4^nub-AC-62

(Marcogliese et al., 2022)

Suppressor of

Statement

Reference

Hsap\IRF2BPL^UAS.cBa, Scer\GAL4^nub-AC-62 is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^nub-AC-62, dsh^UAS.Tag:MYC

(Marcogliese et al., 2022)

Hsap\IRF2BPL^UAS.cBa, Scer\GAL4^nub-AC-62 is a suppressor of lethal - all die before end of P-stage phenotype of Scer\GAL4^nub-AC-62, wg^{UAS.cHa.Tag:HA}

(Marcogliese et al., 2022)

Phenotype Manifest In

Suppressed by

Statement

Reference

Hsap\IRF2BPL^UAS.cBa, Scer\GAL4^nub-AC-62 has wing margin phenotype, suppressible by wg^{UAS.cHa.Tag:HA}, Scer\GAL4^nub-AC-62

(Marcogliese et al., 2022)

Hsap\IRF2BPL^UAS.cBa, Scer\GAL4^nub-AC-62 has wing margin phenotype, suppressible | partially by CkIα^JF01792, Scer\GAL4^nub-AC-62

(Marcogliese et al., 2022)

Suppressor of

Statement

Reference

Hsap\IRF2BPL^UAS.cBa, Scer\GAL4^nub-AC-62 is a suppressor | partially of wing phenotype of Scer\GAL4^nub-AC-62, dsh^UAS.Tag:MYC

(Marcogliese et al., 2022)

Hsap\IRF2BPL^UAS.cBa, Scer\GAL4^nub-AC-62 is a suppressor | partially of wing hair | ectopic phenotype of Scer\GAL4^nub-AC-62, dsh^UAS.Tag:MYC

(Marcogliese et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

78509

y¹ w^*; PBac{UAS-hIRF2BPL.B}VK00037

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Hsap\IRF2BPL^UAS.cBa

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections