FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Ecol\lexAGAD.ple.Tag:NLS(SV40-largeT)
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General Information
Symbol
Ecol\lexAGAD.ple.Tag:NLS(SV40-largeT)
Species
E. coli
Name
FlyBase ID
FBal0340314
Feature type
allele
Associated gene
Ecol\lexA
Associated Insertion(s)
Carried in Construct
P{ple-nlsLexA::GAD}
Also Known As
TH-lexA
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Berry et al., 2015)
Progenitor genotype
Carried in construct
P{ple-nlsLexA::GAD}
Cytology
Description

ple regulatory sequences drive expression of a lexA::GAD driver, tagged with Tag:NLS(SV40-largeT).

(Berry et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
ple
Encoded product / tool
lexA::GAD
Tagged with
Tag:NLS(SV40-largeT)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      adult brain | restricted
      (Berry et al., 2015)
      dopaminergic neuron
      (Cervantes-Sandoval et al., 2017, Berry et al., 2015)
      mushroom body medial-vertical lobe arborizing neuron 1
      (Berry et al., 2015)
      mushroom body vertical lobe arborizing neuron 1
      (Berry et al., 2015)
      adult protocerebrum | restricted
      (Berry et al., 2015)
      Additional Information
      Statement
      Reference

      Drives expression in dopaminergic neurons.

      (FlyBase Curators, 2017)
       
      Marker for
      dopaminergic neuron
      (Cervantes-Sandoval et al., 2017, Berry et al., 2015)
      Reflects expression of
      ple
      (Cervantes-Sandoval et al., 2017, Berry et al., 2015)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Thermogenetic activation (using TrpA1lexAop.cBa at 32[o]C) of Ecol\lexAGAD.ple.Tag:NLS(SV40-largeT) cells in adults significantly reduces startle-induced climbing behavior, compared to controls.

      (Sun et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ecol\lexAGAD.ple.Tag:NLS(SV40-largeT)
      Name Synonyms
      Secondary FlyBase IDs
        References (18)