FlyBase Allele Report: Dmel\amx[ΔCDS]

General Information

Symbol

Dmel\amx^ΔCDS

Species

D. melanogaster

Name

FlyBase ID

FBal0341603

Feature type

allele

Associated gene

Dmel\amx

Associated Insertion(s)

TI{y^wing2+}amx^ΔCDS

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Li-Kroeger et al., 2018)

Mutagen

gene targeting by homologous recombination

(Li-Kroeger et al., 2018)

CRISPR/Cas9

(Li-Kroeger et al., 2018)

Progenitor genotype

Associated Insertion(s)

TI{y^wing2+}amx^ΔCDS

Cytology

Description

The amx coding sequence has been replaced with the TI{y^wing2+} cassette.

(Li-Kroeger et al., 2018)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

X:9,246,123..9,247,330 [-]

Comment:

The amx coding sequence has been replaced with the TI{y^wing2+} cassette.

(Li-Kroeger, 2020.12.30)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Alzheimer's disease

CEA

(Salazar et al., 2021)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of Alzheimer's disease

is ameliorated by Hsap\TM2D3^amx.1

(Salazar et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

dorsal longitudinal indirect flight muscle cell

(Salazar et al., 2021)

larval nervous system | embryonic stage | maternal effect

(Salazar et al., 2021)

mesothoracic tergotrochanter muscle cell

(Salazar et al., 2021)

Detailed Description

Statement

Reference

Embryos from amx^ΔCDS homozygous mothers exhibit a neurogenic phenotype and do not hatch. amx^ΔCDS homozygous DLM and TTM muscles show a progressive failure rate at 50 and 100 Hz.

(Salazar et al., 2021)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

amx^ΔCDS has lethal - all die during embryonic stage | maternal effect phenotype, non-enhanceable by amrt^Δ/amrt^Δ

(Salazar et al., 2021)

amx^ΔCDS has neurogenic phenotype | embryonic stage | maternal effect phenotype, non-enhanceable by amrt^Δ/amrt^Δ

(Salazar et al., 2021)

amx^ΔCDS has neurogenic phenotype | embryonic stage | maternal effect phenotype, non-enhanceable by amrt^Δ/amrt^Δ/bisc^Δ/bisc^Δ

(Salazar et al., 2021)

amx^ΔCDS has lethal - all die during embryonic stage | maternal effect phenotype, non-enhanceable by amrt^Δ/amrt^Δ/bisc^Δ/bisc^Δ

(Salazar et al., 2021)

Suppressed by

Statement

Reference

amx^ΔCDS has increased mortality during development | maternal effect phenotype, suppressible | partially by Hsap\TM2D3^amx.1

(Salazar et al., 2021)

amx^ΔCDS has neurogenic phenotype | maternal effect | embryonic stage phenotype, suppressible by Hsap\TM2D3^amx.1

(Salazar et al., 2021)

amx^ΔCDS has short lived phenotype, suppressible | partially by Hsap\TM2D3^amx.1

(Salazar et al., 2021)

amx^ΔCDS has abnormal neurophysiology | adult stage | progressive phenotype, suppressible by Hsap\TM2D3^amx.1

(Salazar et al., 2021)

NOT suppressed by

Statement

Reference

amx^ΔCDS has lethal - all die during embryonic stage | maternal effect phenotype, non-suppressible by amrt^Δ/amrt^Δ

(Salazar et al., 2021)

amx^ΔCDS has neurogenic phenotype | maternal effect | embryonic stage phenotype, non-suppressible by amrt^Δ/amrt^Δ

(Salazar et al., 2021)

amx^ΔCDS has neurogenic phenotype | maternal effect | embryonic stage phenotype, non-suppressible by amrt^Δ/amrt^Δ/bisc^Δ/bisc^Δ

(Salazar et al., 2021)

amx^ΔCDS has lethal - all die during embryonic stage | maternal effect phenotype, non-suppressible by amrt^Δ/amrt^Δ/bisc^Δ/bisc^Δ

(Salazar et al., 2021)

amx^ΔCDS has lethal - all die during embryonic stage | maternal effect phenotype, non-suppressible by amrt^+tSa

(Salazar et al., 2021)

amx^ΔCDS has lethal - all die during embryonic stage | maternal effect phenotype, non-suppressible by bisc^sfGFP-TVPTBF

(Salazar et al., 2021)

NOT Enhancer of

Statement

Reference

bisc^Δ, bisc^Δ, amx^ΔCDS, amx^ΔCDS is a non-enhancer of lethal - all die during embryonic stage | maternal effect phenotype of amrt^Δ

(Salazar et al., 2021)

bisc^Δ, bisc^Δ, amx^ΔCDS, amx^ΔCDS is a non-enhancer of neurogenic phenotype | embryonic stage | maternal effect phenotype of amrt^Δ

(Salazar et al., 2021)

amrt^Δ, amrt^Δ, amx^ΔCDS, amx^ΔCDS is a non-enhancer of lethal - all die during embryonic stage | maternal effect phenotype of bisc^Δ

(Salazar et al., 2021)

amrt^Δ, amrt^Δ, amx^ΔCDS, amx^ΔCDS is a non-enhancer of neurogenic phenotype | embryonic stage | maternal effect phenotype of bisc^Δ

(Salazar et al., 2021)

amx^ΔCDS/amx^ΔCDS is a non-enhancer of lethal - all die during embryonic stage | maternal effect phenotype of amrt^Δ

(Salazar et al., 2021)

amx^ΔCDS/amx^ΔCDS is a non-enhancer of neurogenic phenotype | embryonic stage | maternal effect phenotype of amrt^Δ

(Salazar et al., 2021)

NOT Suppressor of

Statement

Reference

bisc^Δ, bisc^Δ, amx^ΔCDS, amx^ΔCDS is a non-suppressor of lethal - all die during embryonic stage | maternal effect phenotype of amrt^Δ

(Salazar et al., 2021)

bisc^Δ, bisc^Δ, amx^ΔCDS, amx^ΔCDS is a non-suppressor of neurogenic phenotype | maternal effect | embryonic stage phenotype of amrt^Δ

(Salazar et al., 2021)

amrt^Δ, amrt^Δ, amx^ΔCDS, amx^ΔCDS is a non-suppressor of lethal - all die during embryonic stage | maternal effect phenotype of bisc^Δ

(Salazar et al., 2021)

amrt^Δ, amrt^Δ, amx^ΔCDS, amx^ΔCDS is a non-suppressor of neurogenic phenotype | maternal effect | embryonic stage phenotype of bisc^Δ

(Salazar et al., 2021)

amx^ΔCDS/amx^ΔCDS is a non-suppressor of lethal - all die during embryonic stage | maternal effect phenotype of amrt^Δ

(Salazar et al., 2021)

amx^ΔCDS/amx^ΔCDS is a non-suppressor of neurogenic phenotype | maternal effect | embryonic stage phenotype of amrt^Δ

(Salazar et al., 2021)

Other

Statement

Reference

Hsap\TM2D3^amx.1, amx^ΔCDS has some die during embryonic stage | maternal effect phenotype

(Salazar et al., 2021)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

amx^ΔCDS has larval nervous system | embryonic stage | maternal effect phenotype, non-enhanceable by amrt^Δ/amrt^Δ/bisc^Δ/bisc^Δ

(Salazar et al., 2021)

amx^ΔCDS has larval nervous system | embryonic stage | maternal effect phenotype, non-enhanceable by amrt^Δ/amrt^Δ

(Salazar et al., 2021)

Suppressed by

Statement

Reference

amx^ΔCDS has larval nervous system | maternal effect | embryonic stage phenotype, suppressible by Hsap\TM2D3^amx.1

(Salazar et al., 2021)

amx^ΔCDS has dorsal longitudinal indirect flight muscle cell phenotype, suppressible by Hsap\TM2D3^amx.1

(Salazar et al., 2021)

amx^ΔCDS has mesothoracic tergotrochanter muscle cell phenotype, suppressible by Hsap\TM2D3^amx.1

(Salazar et al., 2021)

NOT suppressed by

Statement

Reference

amx^ΔCDS has larval nervous system | maternal effect | embryonic stage phenotype, non-suppressible by amrt^Δ/amrt^Δ

(Salazar et al., 2021)

amx^ΔCDS has larval nervous system | maternal effect | embryonic stage phenotype, non-suppressible by amrt^Δ/amrt^Δ/bisc^Δ/bisc^Δ

(Salazar et al., 2021)

NOT Enhancer of

Statement

Reference

bisc^Δ, bisc^Δ, amx^ΔCDS, amx^ΔCDS is a non-enhancer of larval nervous system | embryonic stage | maternal effect phenotype of amrt^Δ

(Salazar et al., 2021)

amrt^Δ, amrt^Δ, amx^ΔCDS, amx^ΔCDS is a non-enhancer of larval nervous system | embryonic stage | maternal effect phenotype of bisc^Δ

(Salazar et al., 2021)

amx^ΔCDS/amx^ΔCDS is a non-enhancer of larval nervous system | embryonic stage | maternal effect phenotype of amrt^Δ

(Salazar et al., 2021)

NOT Suppressor of

Statement

Reference

amx^ΔCDS/amx^ΔCDS is a non-suppressor of larval nervous system | maternal effect | embryonic stage phenotype of amrt^Δ

(Salazar et al., 2021)

bisc^Δ, bisc^Δ, amx^ΔCDS, amx^ΔCDS is a non-suppressor of larval nervous system | maternal effect | embryonic stage phenotype of amrt^Δ

(Salazar et al., 2021)

amrt^Δ, amrt^Δ, amx^ΔCDS, amx^ΔCDS is a non-suppressor of larval nervous system | maternal effect | embryonic stage phenotype of bisc^Δ

(Salazar et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

amx^ΔCDS is rescued by amx^+t3.325

(Salazar et al., 2021)

amx^ΔCDS is rescued by Scer\GAL4^nSyb.PS/amx^UAS.cSa

(Salazar et al., 2021)

amx^ΔCDS is rescued by amx^+t3.325

(Das et al., 2020)

Partially rescued by

amx^ΔCDS is partially rescued by amx^Tag:HA

(Salazar et al., 2021)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

80096

y¹ w^* TI{y^wing2+}amx^ΔCDS

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

amx^DeltaCDS

(Li-Kroeger, 2020.12.30)

amx^N

(Das et al., 2020)

amx^ywing2+

(Li-Kroeger et al., 2018)

amx^Δ

(Salazar et al., 2021)

amx^{ΔCDS,ywing2+}

(Das et al., 2020)

amx^ΔCDS

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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