FlyBase Allele Report: Dmel\amrt[Δ]

General Information

Symbol

Dmel\amrt^Δ

Species

D. melanogaster

Name

FlyBase ID

FBal0371147

Feature type

allele

Associated gene

Dmel\amrt

Associated Insertion(s)

TI{TI}amrt^Δ

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Salazar et al., 2021)

Mutagen

CRISPR/Cas9

(Salazar et al., 2021)

Progenitor genotype

Associated Insertion(s)

TI{TI}amrt^Δ

Cytology

Description

The 'yellow[body+]' marker has replaced the amrt coding region.

(Salazar et al., 2021)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:13,782,530..13,783,488 [+]

Comment:

The 'yellow[body+]' marker is inserted in place of the amrt coding region.

(Li-Kroeger and Yamamoto, 2022.2.14)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Alzheimer's disease

CEA

(Salazar et al., 2021)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | maternal effect

(Salazar et al., 2021)

neurogenic phenotype | embryonic stage | maternal effect

(Salazar et al., 2021)

short lived

(Salazar et al., 2021)

viable

(Salazar et al., 2021)

Phenotype Manifest In

larval nervous system | embryonic stage | maternal effect

(Salazar et al., 2021)

Detailed Description

Statement

Reference

Embryos from amrt^Δ homozygous mothers exhibit a neurogenic phenotype and do not hatch.

(Salazar et al., 2021)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

amrt^Δ has lethal - all die during embryonic stage | maternal effect phenotype, non-enhanceable by bisc^Δ/bisc^Δ/amx^ΔCDS/amx^ΔCDS

(Salazar et al., 2021)

amrt^Δ has neurogenic phenotype | embryonic stage | maternal effect phenotype, non-enhanceable by bisc^Δ/bisc^Δ/amx^ΔCDS/amx^ΔCDS

(Salazar et al., 2021)

amrt^Δ has lethal - all die during embryonic stage | maternal effect phenotype, non-enhanceable by amx^ΔCDS/amx^ΔCDS

(Salazar et al., 2021)

amrt^Δ has neurogenic phenotype | embryonic stage | maternal effect phenotype, non-enhanceable by amx^ΔCDS/amx^ΔCDS

(Salazar et al., 2021)

NOT suppressed by

Statement

Reference

amrt^Δ has lethal - all die during embryonic stage | maternal effect phenotype, non-suppressible by amx^ΔCDS/amx^ΔCDS

(Salazar et al., 2021)

amrt^Δ has neurogenic phenotype | maternal effect | embryonic stage phenotype, non-suppressible by amx^ΔCDS/amx^ΔCDS

(Salazar et al., 2021)

amrt^Δ has lethal - all die during embryonic stage | maternal effect phenotype, non-suppressible by bisc^Δ/bisc^Δ/amx^ΔCDS/amx^ΔCDS

(Salazar et al., 2021)

amrt^Δ has neurogenic phenotype | maternal effect | embryonic stage phenotype, non-suppressible by bisc^Δ/bisc^Δ/amx^ΔCDS/amx^ΔCDS

(Salazar et al., 2021)

NOT Enhancer of

Statement

Reference

amrt^Δ/amrt^Δ is a non-enhancer of lethal - all die during embryonic stage | maternal effect phenotype of amx^ΔCDS

(Salazar et al., 2021)

amrt^Δ/amrt^Δ is a non-enhancer of neurogenic phenotype | embryonic stage | maternal effect phenotype of amx^ΔCDS

(Salazar et al., 2021)

amrt^Δ, amrt^Δ, bisc^Δ, bisc^Δ is a non-enhancer of neurogenic phenotype | embryonic stage | maternal effect phenotype of amx^ΔCDS

(Salazar et al., 2021)

amrt^Δ, amrt^Δ, bisc^Δ, bisc^Δ is a non-enhancer of lethal - all die during embryonic stage | maternal effect phenotype of amx^ΔCDS

(Salazar et al., 2021)

amrt^Δ, amrt^Δ, amx^ΔCDS, amx^ΔCDS is a non-enhancer of lethal - all die during embryonic stage | maternal effect phenotype of bisc^Δ

(Salazar et al., 2021)

amrt^Δ, amrt^Δ, amx^ΔCDS, amx^ΔCDS is a non-enhancer of neurogenic phenotype | embryonic stage | maternal effect phenotype of bisc^Δ

(Salazar et al., 2021)

NOT Suppressor of

Statement

Reference

amrt^Δ/amrt^Δ is a non-suppressor of lethal - all die during embryonic stage | maternal effect phenotype of amx^ΔCDS

(Salazar et al., 2021)

amrt^Δ/amrt^Δ is a non-suppressor of neurogenic phenotype | maternal effect | embryonic stage phenotype of amx^ΔCDS

(Salazar et al., 2021)

amrt^Δ, amrt^Δ, amx^ΔCDS, amx^ΔCDS is a non-suppressor of lethal - all die during embryonic stage | maternal effect phenotype of bisc^Δ

(Salazar et al., 2021)

amrt^Δ, amrt^Δ, amx^ΔCDS, amx^ΔCDS is a non-suppressor of neurogenic phenotype | maternal effect | embryonic stage phenotype of bisc^Δ

(Salazar et al., 2021)

amrt^Δ, amrt^Δ, bisc^Δ, bisc^Δ is a non-suppressor of neurogenic phenotype | maternal effect | embryonic stage phenotype of amx^ΔCDS

(Salazar et al., 2021)

amrt^Δ, amrt^Δ, bisc^Δ, bisc^Δ is a non-suppressor of lethal - all die during embryonic stage | maternal effect phenotype of amx^ΔCDS

(Salazar et al., 2021)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

amrt^Δ has larval nervous system | embryonic stage | maternal effect phenotype, non-enhanceable by bisc^Δ/bisc^Δ/amx^ΔCDS/amx^ΔCDS

(Salazar et al., 2021)

amrt^Δ has larval nervous system | embryonic stage | maternal effect phenotype, non-enhanceable by amx^ΔCDS/amx^ΔCDS

(Salazar et al., 2021)

NOT suppressed by

Statement

Reference

amrt^Δ has larval nervous system | maternal effect | embryonic stage phenotype, non-suppressible by amx^ΔCDS/amx^ΔCDS

(Salazar et al., 2021)

amrt^Δ has larval nervous system | maternal effect | embryonic stage phenotype, non-suppressible by bisc^Δ/bisc^Δ/amx^ΔCDS/amx^ΔCDS

(Salazar et al., 2021)

NOT Enhancer of

Statement

Reference

amrt^Δ, amrt^Δ, bisc^Δ, bisc^Δ is a non-enhancer of larval nervous system | embryonic stage | maternal effect phenotype of amx^ΔCDS

(Salazar et al., 2021)

amrt^Δ, amrt^Δ, amx^ΔCDS, amx^ΔCDS is a non-enhancer of larval nervous system | embryonic stage | maternal effect phenotype of bisc^Δ

(Salazar et al., 2021)

amrt^Δ/amrt^Δ is a non-enhancer of larval nervous system | embryonic stage | maternal effect phenotype of amx^ΔCDS

(Salazar et al., 2021)

NOT Suppressor of

Statement

Reference

amrt^Δ, amrt^Δ, amx^ΔCDS, amx^ΔCDS is a non-suppressor of larval nervous system | maternal effect | embryonic stage phenotype of bisc^Δ

(Salazar et al., 2021)

amrt^Δ/amrt^Δ is a non-suppressor of larval nervous system | maternal effect | embryonic stage phenotype of amx^ΔCDS

(Salazar et al., 2021)

amrt^Δ, amrt^Δ, bisc^Δ, bisc^Δ is a non-suppressor of larval nervous system | maternal effect | embryonic stage phenotype of amx^ΔCDS

(Salazar et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

amrt^Δ is partially rescued by amrt^+tSa

(Salazar et al., 2021)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

94064

y¹ w^* TI{TI}amrt^Δ

94067

y¹ w^* TI{TI}amrt^Δ; PBac{amrt^+tSa}VK00037

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

amrt^Δ

(Salazar et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

Open Close