FlyBase Allele Report: Dmel\bisc[Δ]

General Information

Symbol

Dmel\bisc^Δ

Species

D. melanogaster

Name

FlyBase ID

FBal0371149

Feature type

allele

Associated gene

Dmel\bisc

Associated Insertion(s)

TI{TI}bisc^Δ

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Salazar et al., 2021)

Progenitor genotype

Associated Insertion(s)

TI{TI}bisc^Δ

Cytology

Description

The 'yellow[body+]' marker has replaced the bisc coding region.

(Salazar et al., 2021)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

2R:21,383,165..21,384,426 [-]

Comment:

The 'yellow[body+]' marker is inserted in place of the bisc coding region.

(Li-Kroeger and Yamamoto, 2022.2.14)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Alzheimer's disease

CEA

(Salazar et al., 2021)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | maternal effect

(Salazar et al., 2021)

neurogenic phenotype | embryonic stage | maternal effect

(Salazar et al., 2021)

short lived

(Salazar et al., 2021)

viable

(Salazar et al., 2021)

Phenotype Manifest In

larval nervous system | embryonic stage | maternal effect

(Salazar et al., 2021)

Detailed Description

Statement

Reference

Embryos from bisc^Δ homozygous mothers exhibit a neurogenic phenotype and do not hatch.

(Salazar et al., 2021)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

bisc^Δ has lethal - all die during embryonic stage | maternal effect phenotype, non-enhanceable by amrt^Δ/amrt^Δ/amx^ΔCDS/amx^ΔCDS

(Salazar et al., 2021)

bisc^Δ has neurogenic phenotype | embryonic stage | maternal effect phenotype, non-enhanceable by amrt^Δ/amrt^Δ/amx^ΔCDS/amx^ΔCDS

(Salazar et al., 2021)

NOT suppressed by

Statement

Reference

bisc^Δ has lethal - all die during embryonic stage | maternal effect phenotype, non-suppressible by amrt^Δ/amrt^Δ/amx^ΔCDS/amx^ΔCDS

(Salazar et al., 2021)

bisc^Δ has neurogenic phenotype | maternal effect | embryonic stage phenotype, non-suppressible by amrt^Δ/amrt^Δ/amx^ΔCDS/amx^ΔCDS

(Salazar et al., 2021)

NOT Enhancer of

Statement

Reference

amrt^Δ, amrt^Δ, bisc^Δ, bisc^Δ is a non-enhancer of neurogenic phenotype | embryonic stage | maternal effect phenotype of amx^ΔCDS

(Salazar et al., 2021)

amrt^Δ, amrt^Δ, bisc^Δ, bisc^Δ is a non-enhancer of lethal - all die during embryonic stage | maternal effect phenotype of amx^ΔCDS

(Salazar et al., 2021)

bisc^Δ, bisc^Δ, amx^ΔCDS, amx^ΔCDS is a non-enhancer of lethal - all die during embryonic stage | maternal effect phenotype of amrt^Δ

(Salazar et al., 2021)

bisc^Δ, bisc^Δ, amx^ΔCDS, amx^ΔCDS is a non-enhancer of neurogenic phenotype | embryonic stage | maternal effect phenotype of amrt^Δ

(Salazar et al., 2021)

NOT Suppressor of

Statement

Reference

amrt^Δ, amrt^Δ, bisc^Δ, bisc^Δ is a non-suppressor of neurogenic phenotype | maternal effect | embryonic stage phenotype of amx^ΔCDS

(Salazar et al., 2021)

amrt^Δ, amrt^Δ, bisc^Δ, bisc^Δ is a non-suppressor of lethal - all die during embryonic stage | maternal effect phenotype of amx^ΔCDS

(Salazar et al., 2021)

bisc^Δ, bisc^Δ, amx^ΔCDS, amx^ΔCDS is a non-suppressor of lethal - all die during embryonic stage | maternal effect phenotype of amrt^Δ

(Salazar et al., 2021)

bisc^Δ, bisc^Δ, amx^ΔCDS, amx^ΔCDS is a non-suppressor of neurogenic phenotype | maternal effect | embryonic stage phenotype of amrt^Δ

(Salazar et al., 2021)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

bisc^Δ has larval nervous system | embryonic stage | maternal effect phenotype, non-enhanceable by amrt^Δ/amrt^Δ/amx^ΔCDS/amx^ΔCDS

(Salazar et al., 2021)

NOT suppressed by

Statement

Reference

bisc^Δ has larval nervous system | maternal effect | embryonic stage phenotype, non-suppressible by amrt^Δ/amrt^Δ/amx^ΔCDS/amx^ΔCDS

(Salazar et al., 2021)

NOT Enhancer of

Statement

Reference

amrt^Δ, amrt^Δ, bisc^Δ, bisc^Δ is a non-enhancer of larval nervous system | embryonic stage | maternal effect phenotype of amx^ΔCDS

(Salazar et al., 2021)

bisc^Δ, bisc^Δ, amx^ΔCDS, amx^ΔCDS is a non-enhancer of larval nervous system | embryonic stage | maternal effect phenotype of amrt^Δ

(Salazar et al., 2021)

NOT Suppressor of

Statement

Reference

amrt^Δ, amrt^Δ, bisc^Δ, bisc^Δ is a non-suppressor of larval nervous system | maternal effect | embryonic stage phenotype of amx^ΔCDS

(Salazar et al., 2021)

bisc^Δ, bisc^Δ, amx^ΔCDS, amx^ΔCDS is a non-suppressor of larval nervous system | maternal effect | embryonic stage phenotype of amrt^Δ

(Salazar et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

bisc^Δ is partially rescued by bisc^sfGFP-TVPTBF

(Salazar et al., 2021)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

bisc^Δ

(Salazar et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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