FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\RELAAD.nSyb
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General Information
Symbol
Hsap\RELAAD.nSyb
Species
H. sapiens
Name
FlyBase ID
FBal0343318
Feature type
allele
Associated gene
Hsap\RELA
Associated Insertion(s)
Carried in Construct
PBac{nSyb-p65.AD}
Also Known As
nSyb:AD, nSyb-AD
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Yu et al., 2016)
Progenitor genotype
Carried in construct
PBac{nSyb-p65.AD}
Cytology
Description

The nSyb promoter (1826 to +78) drives expression of a p65(AD)::Zip+ hemidriver (component of the 'Split GAL4' system, contains the GAL4 DNA-binding domain).

(Yu et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
nSyb
Encoded product / tool
p65(AD)::Zip+
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Inhibition (using shi1.UAS at 30[o]C) of neurons targeted by the split-GAL4 pair of Scer\GAL4DBD.AkhR and Hsap\RELAAD.nSyb in adult females results in loss of the significant starvation-induced increase in locomotor activity seen in controls; it does not affect the starvation-induced increase in food intake and does not affect feeding behavior under starvation conditions, compared to controls.

      Activation (using Bhal\NaChBacUAS.cNa) of neurons targeted by the split-GAL4 pair of Scer\GAL4DBD.AkhR and Hsap\RELAAD.nSyb in adult females results in acceleration of starvation-induced hyperactivity, compared to controls; it does not affect the starvation-induced increase in food intake and does not affect feeding behavior under starvation conditions, compared to controls.

      (Yu et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hsap\RELAAD.nSyb
      Name Synonyms
      Secondary FlyBase IDs
        References (4)