FB2026_02 , released June 18, 2026
Allele: Dmel\MarfWT.UAS
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General Information
Symbol
Dmel\MarfWT.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0344035
Feature type
allele
Associated gene
Dmel\Marf
Associated Insertion(s)
Carried in Construct
P{UAS-Marf.WT}
Key Links
Transgenic product class
wild_type
(El Fissi et al., 2018)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(El Fissi et al., 2018)
Mutagen
in vitro construct
(El Fissi et al., 2018)
Progenitor genotype
Carried in construct
P{UAS-Marf.WT}
Cytology
Description

UASt regulates expression of wild type Marf lacking the 5' and 3' UTRs, and with only a kozak CAAA sequence added in front of the ATG.

(El Fissi et al., 2018)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Marf
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of MarfWT.UAS under the control of Scer\GAL4elav.PU does not have a significant effect in adult climbing ability but induces bigger mitochondria in larval motor neuron cell bodies, as compared to controls.

      Expression under the control of Scer\GAL4VGlut-OK371 also induces bigger mitochondria (significantly longer mitochondria segments) in larval motor neuron cell bodies, which are still able to fuse and their cristae and matrix are still electron dense and not distended, but does not significantly affect the number of mitochondria in their neuromuscular boutons, as compared to controls. This expression also leads to a mild decrease in the number of photoreceptor cells per ommatidia, as compared to controls.

      (El Fissi et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The co-expression of MarfWT.UAS and Drp1UAS.Tag:HA under the control of Scer\GAL4elav.PU does not have a significant effect in adult climbing ability, as compared to controls.

      (El Fissi et al., 2018)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      MarfWT.UAS/Scer\GAL4VGlut1-OK371 partially rescues MarfKO.mCherry

      (El Fissi et al., 2018)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      MarfWT.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)