FlyBase Allele Report: Dmel\CCHa2[SK3]

General Information

Symbol

Dmel\CCHa2^SK3

Species

D. melanogaster

Name

FlyBase ID

FBal0344093

Feature type

allele

Associated gene

Dmel\CCHa2

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

loss of function allele

(Ren et al., 2015)

Mutagen

CRISPR/Cas9

(Ren et al., 2015)

Progenitor genotype

Cytology

Description

Deletion of 10bp within CCHa2 results in a frameshift.

(Ren et al., 2015)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:13,390,260..13,390,269 [-]

Comment:

Deletion of 10bp within the CCHa2 coding sequence results in a frameshift and early translaiton termination after the addition of 6 novel amino acids.

(Ren et al., 2015)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate

(Ren et al., 2015)

abnormal developmental rate (with CCHa2^SK1)

(Ren et al., 2015)

abnormal feeding behavior | adult stage (with CCHa2^SK1)

(Ren et al., 2015)

abnormal feeding behavior | third instar larval stage (with CCHa2^SK1)

(Ren et al., 2015)

abnormal locomotor behavior | adult stage (with CCHa2^SK1)

(Ren et al., 2015)

abnormal size | adult stage (with CCHa2^SK1)

(Ren et al., 2015)

Phenotype Manifest In

wing (with CCHa2^SK1)

(Ren et al., 2015)

Detailed Description

Statement

Reference

CCHa2^SK1/CCHa2^SK3 animals exhibit a significantly reduced food intake (in third instar larvae and in adults), locomotion (in adults, specifically during light transitions) and wing surfaces while they don't exhibit any changes in body weight (in adults) when compared to controls.

CCHa2^SK1/CCHa2^SK3, CCHa2^SK3/CCHa2^SK3 and CCHa2^SK3/+ animals exhibit a significantly delayed pupariation when compared to controls.

(Ren et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

CCHa2^SK3/CCHa2^SK1 is partially rescued by CCHa2^UAS.cRa/Scer\GAL4^arm.PU

(Ren et al., 2015)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CCHa2^SK3

ccha2^SK3

(Ren et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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