FlyBase Allele Report: Dmel\Oatp74D[1]

General Information

Symbol

Dmel\Oatp74D¹

Species

D. melanogaster

Name

FlyBase ID

FBal0344737

Feature type

allele

Associated gene

Dmel\Oatp74D

Associated Insertion(s)

Carried in Construct

Also Known As

EcI¹

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

loss of function allele

(Okamoto et al., 2018)

Mutagen

CRISPR/Cas9

(Okamoto et al., 2018)

Progenitor genotype

Cytology

Description

3207bp deletion in Oatp74D, including deletion of the entire coding region.

(Okamoto et al., 2018)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:17,507,892..17,511,098 [+]

Comment:

A 3207bp deletion that removes the Oatp74D coding sequence.

(Okamoto et al., 2018)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | first instar larval stage

(Okamoto et al., 2018)

abnormal developmental rate | first instar larval stage (with Oatp74D²)

(Okamoto et al., 2018)

lethal - all die during first instar larval stage

(Okamoto et al., 2018)

lethal - all die during first instar larval stage (with Oatp74D²)

(Okamoto et al., 2018)

Phenotype Manifest In

embryonic/larval posterior spiracle | first instar larval stage (with Oatp74D²)

(Okamoto et al., 2018)

mouth hook | first instar larval stage | increased number

(Okamoto et al., 2018)

mouth hook | first instar larval stage | increased number (with Oatp74D²)

(Okamoto et al., 2018)

Detailed Description

Statement

Reference

Although Oatp74D¹ homozygotes and Oatp74D¹/Oatp74D¹ transheterozygotes exhibit no discernible defects during embryogenesis and during the first 24 hr after hatching, they show developmental arrest at the end of the first instar larval stage; a small fraction of arrested larvae present double mouth hooks (i.e. carry both first and second instar mouth hooks); transheterozygotes also show a thin posterior spiracle phenotype.

(Okamoto et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Oatp74D²/Oatp74D¹ has abnormal developmental rate | first instar larval stage phenotype, non-enhanceable by phtm^KK103215/Scer\GAL4^phtm.PO

(Okamoto et al., 2018)

NOT suppressed by

Statement

Reference

Oatp74D²/Oatp74D¹ has abnormal developmental rate | first instar larval stage phenotype, non-suppressible by phtm^KK103215/Scer\GAL4^phtm.PO

(Okamoto et al., 2018)

NOT Enhancer of

Statement

Reference

Oatp74D²/Oatp74D¹ is a non-enhancer of abnormal developmental rate | first instar larval stage phenotype of Scer\GAL4^phtm.PO, phtm^KK103215

(Okamoto et al., 2018)

NOT Suppressor of

Statement

Reference

Oatp74D²/Oatp74D¹ is a non-suppressor of abnormal developmental rate | first instar larval stage phenotype of Scer\GAL4^phtm.PO, phtm^KK103215

(Okamoto et al., 2018)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

Oatp74D²/Oatp74D¹ is partially rescued by Oatp74D^UAS.cOa/Scer\GAL4^arm.PS

(Okamoto et al., 2018)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

EcI¹

(Hun et al., 2022, Okamoto et al., 2018)

Oatp74D¹

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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