FlyBase Allele Report: Dmel\PGRP-LB[PCΔ10A]

General Information

Symbol

Dmel\PGRP-LB^PCΔ10A

Species

D. melanogaster

Name

FlyBase ID

FBal0344820

Feature type

allele

Associated gene

Dmel\PGRP-LB

Associated Insertion(s)

Carried in Construct

Also Known As

PGRP-LB^PC*10A

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Charroux et al., 2018)

Progenitor genotype

Cytology

Description

Mutations within the exon that is specific to the PGRP-LB PC isoform. This results in the amino acids MTALGLVLLSM being absent from the N-terminal end of the mutant PC protein.

(Charroux et al., 2018)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:11,457,613..11,457,617 [-]

Comment:

First of two small deletions downstream of ATG of PGRP-LB-RC in mutant. These deletions result in the amino acids MTALGLVLLSM being absent from the N-terminal end of the mutant PC protein.

(Charroux et al., 2018)

deletion

3R:11,457,590..11,457,592 [-]

Comment:

Second of two small deletions downstream of ATG of PGRP-LB-RC in mutant. These deletions result in the amino acids MTALGLVLLSM being absent from the N-terminal end of the mutant PC protein.

(Charroux et al., 2018)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response | conditional

(Charroux et al., 2018)

Phenotype Manifest In

adult fat body | conditional

(Charroux et al., 2018)

adult midgut | conditional

(Charroux et al., 2018)

Detailed Description

Statement

Reference

PGRP-LB^PCΔ10A adults infected with Erwinia carotovora carotovora by oral feeding exhibit a significantly increased immune response (immune deficiency pathway activation) in fat body and midgut compared to controls.

(Charroux et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

PGRP-LB^Δ/PGRP-LB^PCΔ10A is rescued by PGRP-LB^UAS.PC.EGFP/Scer\GAL4^mex1.PU

(Charroux et al., 2018)

PGRP-LB^Δ/PGRP-LB^PCΔ10A is rescued by PGRP-LB^UAS.PC.EGFP/Scer\GAL4^r4

(Charroux et al., 2018)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

PGRP-LB^PC*10A

(Charroux and Royet, 2022, Charroux et al., 2018)

PGRP-LB^PCΔ10A

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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