FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pka-C3d
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General Information
Symbol
Dmel\Pka-C3d
Species
D. melanogaster
Name
FlyBase ID
FBal0345167
Feature type
allele
Associated gene
Dmel\Pka-C3
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Cassar et al., 2018)
Mutagen
FLPase
(Cassar et al., 2018)
Progenitor genotype
PBac{WH}Pka-C3f00695
(Cassar et al., 2018)
PBac{WH}f07226
(Cassar et al., 2018)
Cytology
Description

Deletion that removes all coding exons of the Pka-C3-RA isoform and all coding exons except the first one for the Pka-C3-RB isoform. Generated by FLP-mediated recombination between the two progenitor insertions (PBac{WH}Pka-C3f00695 and PBac{WH}f07226).

(Cassar et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      A significantly reduced number of Pka-C3d/Pka-C3d males attempt copulation, even though they spend a similar amount of time engaging in other courtship-related behaviors compared to wild-type controls. Males display longer periods of activity than controls, but show no difference in walking speed.

      Pka-C3d/Pka-C3d flies lack any overt defects and display normal brain development and integrity during adult life.

      (Cassar et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Pka-C3d is rescued by Scer\GAL4elav.PU/Pka-C3UAS.cBa

      (Cassar et al., 2018)

      Pka-C3d is rescued by Scer\GAL4VP16.natalisin/Pka-C3UAS.cBa

      (Cassar et al., 2018)
      Comments

      Expressing Pka-C3UAS.cBa under the control of either Scer\GAL4elav.PU or Scer\GAL4VP16.natalisin rescues the reduced occurrence of copulation in Pka-C3d/Pka-C3d males.

      (Cassar et al., 2018)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Pka-C3d
      (Cassar et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)