FlyBase Allele Report: Cint\AOX[wt.UAS]

General Information

Symbol

Cint\AOX^wt.UAS

Species

C. intestinalis

Name

FlyBase ID

FBal0350376

Feature type

allele

Associated gene

Cint\AOX

Associated Insertion(s)

Carried in Construct

P{UAS-Cint\AOX.wt}

Also Known As

UAS-wtAOX

Transgenic product class

wild_type

(Andjelković et al., 2015)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Andjelković et al., 2015)

Mutagen

in vitro construct

(Andjelković et al., 2015)

Progenitor genotype

Carried in construct

P{UAS-Cint\AOX.wt}

Cytology

Description

UASt regulates expression of wild type Cint\AOX.

(Andjelković et al., 2015)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Cint\AOX

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

DOES NOT ameliorate autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 3

modeled by mtDNA-helicase^A442P.UAS

(Rodrigues et al., 2018)

modeled by mtDNA-helicase^K388A.UAS

(Rodrigues et al., 2018)

modeled by mtDNA-helicase^KK102418

(Rodrigues et al., 2018)

DOES NOT ameliorate Alpers-Huttenlocher syndrome

modeled by PolG1^KK100485

(Rodrigues et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable, with Scer\GAL4^da.PU

(Rodrigues et al., 2018)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Cint\AOX^wt.UAS, Scer\GAL4^da.PU is an enhancer of increased mortality during development phenotype of Scer\GAL4^da.PU, mtDNA-helicase^A442P.UAS

(Rodrigues et al., 2018)

NOT Enhancer of

Statement

Reference

Cint\AOX^wt.UAS, Scer\GAL4^da.PU is a non-enhancer of lethal - all die before end of prepupal stage phenotype of Scer\GAL4^da.PU, mtDNA-helicase^K388A.UAS

(Rodrigues et al., 2018)

Scer\GAL4^da.PU/Cint\AOX^wt.UAS is a non-enhancer of increased mortality during development phenotype of mtDNA-helicase^KK102418

(Rodrigues et al., 2018)

NOT Suppressor of

Statement

Reference

Cint\AOX^wt.UAS, Scer\GAL4^da.PU is a non-suppressor of lethal - all die before end of prepupal stage phenotype of Scer\GAL4^da.PU, mtDNA-helicase^K388A.UAS

(Rodrigues et al., 2018)

Scer\GAL4^da.PU/Cint\AOX^wt.UAS is a non-suppressor of increased mortality during development phenotype of mtDNA-helicase^KK102418

(Rodrigues et al., 2018)

Cint\AOX^wt.UAS, Scer\GAL4^da.PU is a non-suppressor of increased mortality during development phenotype of PolG1^KK100485, Scer\GAL4^da.PU

(Rodrigues et al., 2018)

Scer\GAL4^da.PU/Cint\AOX^wt.UAS is a non-suppressor of lethal | recessive phenotype of PolG1^Q1009A

(Rodrigues et al., 2018)

Other

Statement

Reference

Cint\AOX^wt.UAS, Scer\GAL4^elav.PU, mtDNA-helicase^K388A.UAS has viable phenotype

(Rodrigues et al., 2018)

Cint\AOX^wt.UAS, Scer\GAL4^Mhc.PU, mtDNA-helicase^K388A.UAS has viable phenotype

(Rodrigues et al., 2018)

Cint\AOX^wt.UAS, Scer\GAL4^elav.PU, mtDNA-helicase^A442P.UAS has viable phenotype

(Rodrigues et al., 2018)

Cint\AOX^wt.UAS, Scer\GAL4^Mhc.PU, mtDNA-helicase^A442P.UAS has viable phenotype

(Rodrigues et al., 2018)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Cint\AOX^wt.UAS

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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