FlyBase Gene Report: Cint\AOX

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Gene: Cint\AOX

General Information

Symbol

Cint\AOX

Species

C. intestinalis

Name

alternative oxidase

Annotation Symbol

Feature Type

engineered_foreign_gene

FlyBase ID

FBgn0284300

Gene Model Status

Stock Availability

6 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Also Known As

AOX

Foreign Gene Data

Foreign sequence; species == Ciona intestinalis; gene == 'AOX, alternative oxidase'.

(FlyBase Curators, 1992-)

Summaries

Alleles, Insertions, Transgenic Constructs

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cint\AOX

Transgenic constructs containing regulatory region of Cint\AOX

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Scer\GAL4^da.PU

Sterility

Allele

fertile, with Scer\GAL4^da.G32

Cint\AOX^UAS.cFa

Other Phenotypes

Allele

chemical resistant, with Scer\GAL4^da.G32

Cint\AOX^UAS.cFa

chemical resistant | adult stage

Cint\AOX^αTub84B.PK

Phenotype manifest in

Allele

mitochondrion, with Scer\GAL4^da.G32

Cint\AOX^UAS.cFa

Orthologs

Downloads

Download All DIOPT Orthologs

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

mitochondrial complex IV dysfunction, general model

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

Cint\AOX^αTub84B.PK

ameliorates cytochrome-c oxidase deficiency disease

modeled by COX5A^GD5167

(Kemppainen et al., 2014)

modeled by COX5B^GD6659

(Kemppainen et al., 2014)

modeled by cype^GD908

(Kemppainen et al., 2014)

modeled by levy¹

(Kemppainen et al., 2014)

Cint\AOX^UAS.cFa

DOES NOT ameliorate mitochondrial metabolism disease

modeled by tko^25t

(Kemppainen et al., 2014)

ameliorates Parkinson's disease 7

modeled by dj-1β^GE23381

(Fernandez-Ayala et al., 2009)

ameliorates cytochrome-c oxidase deficiency disease

modeled by COX4^KK107510

(Kemppainen et al., 2014)

modeled by COX5B^GD6659

(Kemppainen et al., 2014)

modeled by COX7A^KK110870

(Kemppainen et al., 2014)

modeled by levy^KK108963

(Kemppainen et al., 2014)

DOES NOT ameliorate autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 3

modeled by mtDNA-helicase^A442P.UAS

(Rodrigues et al., 2018)

modeled by mtDNA-helicase^K388A.UAS

(Rodrigues et al., 2018)

modeled by mtDNA-helicase^KK102418

(Rodrigues et al., 2018)

DOES NOT ameliorate Alpers-Huttenlocher syndrome

modeled by PolG1^KK100485

(Rodrigues et al., 2018)

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Campesan et al., 2023)

Cint\AOX^wt.UAS

DOES NOT ameliorate autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 3

modeled by mtDNA-helicase^A442P.UAS

(Rodrigues et al., 2018)

modeled by mtDNA-helicase^K388A.UAS

(Rodrigues et al., 2018)

modeled by mtDNA-helicase^KK102418

(Rodrigues et al., 2018)

DOES NOT ameliorate Alpers-Huttenlocher syndrome

modeled by PolG1^KK100485

(Rodrigues et al., 2018)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Class of Gene

engineered_foreign_gene

(FlyBase Curators, 1992-)

Stocks and Reagents

Stocks (6)

93888

w¹¹¹⁸; P{tub-AOX.K}7

93880

w¹¹¹⁸; P{UAS-AOX.F}F6

93886

w¹¹¹⁸, P{tub-AOX.K}35

93881

w¹¹¹⁸; P{UAS-AOX.F}F24

93887

w¹¹¹⁸; P{tub-AOX.K}112

93879

w¹¹¹⁸, P{tub-AOX.K}35; P{tub-AOX.K}112; P{tub-AOX.K}7

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

AOX

(Ojha et al., 2022, Andjelković et al., 2015, Senyilmaz et al., 2015, Kemppainen et al., 2014, Kemppainen et al., 2014, Vartiainen et al., 2014, Humphrey et al., 2012, Vilain et al., 2012, Sanz et al., 2010, Fernandez-Ayala et al., 2009)

Cint\AOX

Zzzz\AOX

Name Synonyms

Alternative Oxidase

(Sanz et al., 2010)

Alternative oxidase

(Humphrey et al., 2012)

alternative oxidase

(Vartiainen et al., 2014)

Secondary FlyBase IDs

FBgn0284133
FBgn0264333

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 0 )

References (24)