FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Patroninc9-c5
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General Information
Symbol
Dmel\Patroninc9-c5
Species
D. melanogaster
Name
FlyBase ID
FBal0351742
Feature type
allele
Associated gene
Dmel\Patronin
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    loss of function allele

    (Wang et al., 2019)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Two lesions within the second coding exon of Patronin; a GC to TA substitution that changes Met Pro to Ile Ser, and a deletion of a G nucleotide that changes Glu Thr Val Leu to Lys Arg Tyr STOP, resulting in a premature stop codon after 105 amino acids.

    (Nashchekin et al., 2021)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    delins
    2R:17,531,906..17,531,916 [-]
    Comment:

    GCCCATTACCG is changed to TACCATTACC in the second exon of Patronin. The result is a change from Met Pro to Ile Ser at amino acid 99/100 and a frameshift after aa102 leading to early translation termination after 105 amino acids.

    Inserted_sequence:

    TACCATTACC

    (Nashchekin et al., 2021)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Patroninc9-c5 homozygous mutant clones (induced using Scer\FLP1SOP.scE1x6) have a failure to prune all ddaC dendrites by 16 h after puparium formation (APF), unlike controls; ddaC dendrite arbors are also simplified at the white prepupal stage, compared to controls; ddaC clones have significantly reduced numbers of dendritic termini at the wandering third instar stage, compared to controls, despite similar numbers of primary and secondary dendrites; there is also an increase in plus-end out microtubules in larval ddaC dendrites, compared to controls.

        (Wang et al., 2019)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        Patroninc9-c5
        patrc9-c5
        (Wang et al., 2019)
        patroninc9-c5
        (Nashchekin et al., 2021, Wang et al., 2019)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)