FlyBase Allele Report: Dmel\sip3[1]

General Information

Symbol

Dmel\sip3¹

Species

D. melanogaster

Name

FlyBase ID

FBal0357022

Feature type

allele

Associated gene

Dmel\sip3

Associated Insertion(s)

Carried in Construct

Also Known As

hrd1¹

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Xiong et al., 2020)

Mutagen

CRISPR/Cas9

(Xiong et al., 2020)

Progenitor genotype

Cytology

Description

Deletion of the majority of the CDS of sip3, encompassing exons 3-6.

(Xiong et al., 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

sip3¹, Df(1)sordd1-2¹ double mutants exhibit retinal degeneration, with prominent vacuoles and obvious loss of rhabdomeres and photoreceptors

(Xu et al., 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\FLP1^ey.PU/sordd1^UAS.cXa, sip3¹, sip3¹, Scer\GAL4^GMR.PU is a suppressor of visible | somatic clone | adult stage phenotype of Scer\GAL4^GMR.PU, ninaE^G69D.UAS.cXa

(Xu et al., 2020)

Other

Statement

Reference

Df(1)sordd1-2¹, sip3¹ has abnormal neuroanatomy | adult stage | progressive phenotype

(Xu et al., 2020)

Df(1)sordd1-2¹, sip3¹ has decreased cell number | adult stage | progressive phenotype

(Xu et al., 2020)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\FLP1^ey.PU/sordd1^UAS.cXa, sip3¹, sip3¹, Scer\GAL4^GMR.PU is a suppressor of eye | somatic clone phenotype of Scer\GAL4^GMR.PU, ninaE^G69D.UAS.cXa

(Xu et al., 2020)

Scer\FLP1^ey.PU/sordd1^UAS.cXa, sip3¹, sip3¹, Scer\GAL4^GMR.PU is a suppressor of ommatidium | somatic clone | decreased number phenotype of Scer\GAL4^GMR.PU, ninaE^G69D.UAS.cXa

(Xu et al., 2020)

Other

Statement

Reference

Df(1)sordd1-2¹, sip3¹ has retina phenotype

(Xu et al., 2020)

Df(1)sordd1-2¹, sip3¹ has eye photoreceptor cell | decreased number phenotype

(Xu et al., 2020)

Df(1)sordd1-2¹, sip3¹ has rhabdomere of eye photoreceptor cell | decreased number phenotype

(Xu et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

86518

w^*; P{neoFRT}82B sip3¹/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

hrd1¹

(Xiong et al., 2020, Xu et al., 2020)

sip3¹

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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