FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\vgCL2C
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General Information
Symbol
Dmel\vgCL2C
Species
D. melanogaster
Name
FlyBase ID
FBal0359435
Feature type
allele
Associated gene
Dmel\vg
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Ahmad and Spens, 2019)
Progenitor genotype
Cytology
Description

C to T substitution at position +296 relative to the vg transcription start site. The mutation is within the proximal Polycomb response element (PRE), in the major Pc protein binding site.

(Ahmad and Spens, 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:12,884,497..12,884,497 [+]
Nucleotide change:

C12884497T

Comment:

C to T substitution at position +296 relative to the vg transcription start site. The mutation is within the proximal Polycomb response element (PRE), in the major Pc protein binding site.

(Ahmad and Spens, 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      vgCL2C in transheterozygosity with Df(2R)Exel8056, Df(2R)vg-D, vgnw or vgDJ1R22 leads to wing defects, while vgCL2C in homozygosity or in transheterozygosity with vg13A, vgCL1, vgCZ or vgR5 does not.

      (Ahmad and Spens, 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      vgCL2C/vgnw has visible | adult stage phenotype, enhanceable by Pc3/Pc[+]

      (Ahmad and Spens, 2019)

      vgCL2C/vgnw has visible | adult stage phenotype, enhanceable by Sceunspecified/Sce[+]

      (Ahmad and Spens, 2019)
      Other
      Statement
      Reference

      Pc3, vgCL2C has visible | adult stage phenotype

      (Ahmad and Spens, 2019)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      vgCL2C/vgnw has wing phenotype, enhanceable by Pc3/Pc[+]

      (Ahmad and Spens, 2019)

      vgCL2C/vgnw has wing phenotype, enhanceable by Sceunspecified/Sce[+]

      (Ahmad and Spens, 2019)
      Other
      Statement
      Reference

      Pc3, vgCL2C has wing phenotype

      (Ahmad and Spens, 2019)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      vgCL2C, Pc3 double heterozygotes display deformed wings.

      Heterozygosity for Pc3 or Sceunspecified enhances the wing defects of vgCL2C/vgnw.

      (Ahmad and Spens, 2019)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      vgCL2C
      (Ahmad and Spens, 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)