FlyBase Allele Report: Dmel\eIF2D[CR1]

General Information

Symbol

Dmel\eIF2D^CR1

Species

D. melanogaster

Name

FlyBase ID

FBal0363459

Feature type

allele

Associated gene

Dmel\eIF2D

Associated Insertion(s)

TI{TI}eIF2D^CR1

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Vasudevan et al., 2020)

Mutagen

CRISPR/Cas9

(Vasudevan et al., 2020)

gene targeting by homologous recombination

(Vasudevan et al., 2020)

Progenitor genotype

Associated Insertion(s)

TI{TI}eIF2D^CR1

Cytology

Description

22bp deletion in the first exon of eIF2D, within the 5'UTR. A loxP cassette containing a Disc\RFP^3xP3.cUa marker has been inserted in place of the deleted sequence.

(Vasudevan et al., 2020)

Allele components

Component

Use(s)

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased mortality during development | nutrition conditional

(Vasudevan et al., 2020)

partially lethal - majority live

(Vasudevan et al., 2020)

some die during larval stage

(Vasudevan et al., 2020)

some die during P-stage

(Vasudevan et al., 2020)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

DENR^KO, eIF2D^CR1 has some die during larval stage phenotype

(Vasudevan et al., 2020)

DENR^KO, eIF2D^CR1 has lethal - all die before end of P-stage phenotype

(Vasudevan et al., 2020)

DENR^KO, eIF2D^CR1 has majority die during P-stage phenotype

(Vasudevan et al., 2020)

DENR^KO, eIF2D^CR1 has visible | P-stage phenotype

(Vasudevan et al., 2020)

DENR^KO, eIF2D^CR1 has increased mortality during development | nutrition conditional phenotype

(Vasudevan et al., 2020)

Phenotype Manifest In

Other

Statement

Reference

DENR^KO, eIF2D^CR1 has pupa phenotype

(Vasudevan et al., 2020)

DENR^KO, eIF2D^CR1 has anterior pupal spiracle | absent phenotype

(Vasudevan et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

eIF2D^CR1

(Vasudevan et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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