FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Cyp40KO
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General Information
Symbol
Dmel\Cyp40KO
Species
D. melanogaster
Name
FlyBase ID
FBal0365203
Feature type
allele
Associated gene
Dmel\Cyp40
Associated Insertion(s)
TI{TI}Cyp40KO
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Iki et al., 2020)
Mutagen
CRISPR/Cas9
(Iki et al., 2020)
gene targeting by homologous recombination
(Iki et al., 2020)
Progenitor genotype
Associated Insertion(s)
TI{TI}Cyp40KO
Cytology
Description

A stop codon is introducecd into the middle of the open reading frame of Cyp40.

(Iki et al., 2020)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
insertion
3L:9,631,054..9,631,055 [+]
Inserted_sequence:

TAA

Comment:

The stop codon TAA has been inserted after codon 188 leading to early translation termination.

(Iki and Kai, 2021.3.17)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous Cyp40KO testis exhibit defects in the axoneme structure, individualization complex organization and mature sperm accumulation in the seminal vesicles when compared to controls.

      (Iki et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Cyp40KO
      (Iki and Kai, 2021.3.17)
      cyp40KO
      (Iki et al., 2023)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)