FlyBase Gene Report: Dmel\Cyp40

General Information

Symbol

Dmel\Cyp40

Species

D. melanogaster

Name

Cyclophilin 40

Annotation Symbol

CG8336

Feature Type

protein_coding_gene

FlyBase ID

FBgn0036020

Gene Model Status

Current

Stock Availability

5 publicly available

Enzyme Name (EC)

peptidylprolyl isomerase (5.2.1.8)

Gene Summary

Cyclophilin 40 (Cyp40) encodes a protein with essential functions in germ cells during sperm maturation. As a co-chaperone of Hsp83, Cyp40 forms complexes with Argonaute (Ago) proteins and small RNA intermediate duplexes, and controls the silencing effector formation by AGO2 in the testis. [Date last reviewed: 2021-01-21] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

67C2-67C3

Sequence location

3L:9,628,676..9,631,795 [+]

Recombination map

3-31

RefSeq locus

NT_037436 REGION:9628676..9631795

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables cyclosporin A binding

inferred from biological aspect of ancestor with PANTHER:PTN008511653

(GO Reference Genome Project, 2011-)

enables peptidyl-prolyl cis-trans isomerase activity

inferred from electronic annotation with InterPro:IPR002130

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN008511653

(GO Reference Genome Project, 2011-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in piRNA processing

inferred from mutant phenotype

(Iki et al., 2023)

involved_in piRNA-mediated gene silencing by mRNA destabilization

inferred from mutant phenotype

(Iki et al., 2023)

involved_in RISC complex assembly

inferred from genetic interaction with FLYBASE:AGO2; FB:FBgn0087035

(Iki et al., 2020)

acts_upstream_of_positive_effect spermatogenesis

inferred from mutant phenotype

(Iki et al., 2020)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in protein folding

inferred from biological aspect of ancestor with PANTHER:PTN008511653

(GO Reference Genome Project, 2011-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

is_active_in cytosol

inferred from direct assay

(Iki et al., 2020)

part_of protein folding chaperone complex

inferred from direct assay

(Iki et al., 2020)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of catalytic step 2 spliceosome

inferred from biological aspect of ancestor with PANTHER:PTN008511669

(GO Reference Genome Project, 2011-)

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN008511653

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

CYCLOPHILINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

peptidyl-prolyl cis-trans isomerase activity

[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) (5.2.1.8)

RHEA 16237:

Summaries

Gene Snapshot

Gene Group (FlyBase)

CYCLOPHILINS -: Cyclophilins are a class of evolutionary conserved peptidyl prolyl cis/trans isomerases. In vertebrates, they form binary complexes with their ligand, cyclosporine A, and are involved in key biochemical processes including protein folding, receptor signalling, protein trafficking, and transcription. Cyclophilins are characterized by the presence of a 'Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain' (IPR002130). (Adapted from PMID:25986569.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Cyp40 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VT21)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Cyp40-RA

FBtr0076385

NM_140081

1500

383

Cyp40-RB

FBtr0076384

NM_168354

1555

383

Cyp40-RC

FBtr0076386

NM_168355

1445

383

Cyp40-RD

FBtr0333855

NM_001274707

1395

383

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Cyp40-PA

FBpp0076114

43.1

383

7.77

FBpp0076113

43.1

383

7.77

FBpp0076115

43.1

383

7.77

FBpp0305988

43.1

383

7.77

Q9VT21

NP_001261636

AGB94331

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

383 aa isoforms: Cyp40-PA, Cyp40-PB, Cyp40-PC, Cyp40-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cyp40 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

3.35

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

mutational analysis

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

spermatogonium

Comment: data from FlyAtlas

(Zur Lage et al., 2019)

Additional Descriptive Data

As part of a survey of ciliary motility gene homologs in Drosophila, expression of Cyp40 was assayed in motile ciliated cell types. Expression was observed in sperm (testis) but not chordotonal neurons.

(Zur Lage et al., 2019)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

testis

(Iki et al., 2020)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

is_active_in cytosol

inferred from direct assay

(Iki et al., 2020)

part_of protein folding chaperone complex

inferred from direct assay

(Iki et al., 2020)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cyp40 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cyp40

View exonic expression by tissue for Dmel\Cyp40

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0036020

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39121/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0036020

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036020

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0036020

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8336

Flygut - An atlas of the Drosophila adult midgut

FBgn0036020

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Cyp40

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cyp40

Transgenic constructs containing regulatory region of Cyp40

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3L)Exel6114

(Ryder, 2004.4.26)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Cyp40^GD13759

viable, with Scer\GAL4^Mef2.PR

Cyp40^GD13759

viable, with Scer\GAL4^pnr-MD237

Cyp40^GD13759

viable, with Scer\GAL4^tin.CΔ4

Cyp40^GD13759

Sterility

Allele

female semi-fertile

Cyp40^KO

male sterile | recessive

Cyp40^KO

Other Phenotypes

Allele

decreased fecundity | male | recessive

Cyp40^KO

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

Cyp40^GD13759

Phenotype manifest in

Allele

spermatid axoneme

Cyp40^KO

spermatozoon | absent

Cyp40^KO

sperm individualization complex

Cyp40^KO

testis

Cyp40^KO

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (43)

Hsap\PPID

12 of 14

Yes

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (36)

Rnor\Ppid

12 of 14

Yes

Rnor\Ppidl1

10 of 14

Yes

5 of 14

5 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (32)

Mmus\Ppid

12 of 14

Yes

5 of 14

5 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (34)

Xtro\ppid

9 of 13

Yes

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (40)

Drer\ppid

11 of 14

Yes

6 of 14

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

4 of 14

3 of 14

3 of 14

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (23)

Cele\cyn-1

5 of 14

Yes

Cele\cyn-2

5 of 14

Yes

Cele\cyn-3

5 of 14

Yes

Cele\cyn-7

5 of 14

Yes

Cele\cyn-9

5 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (27)

Agam\AgaP_AGAP003265

12 of 12

Yes

4 of 12

4 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (47)

Atha\SQN

11 of 13

Yes

Atha\AT2G21130

5 of 13

Atha\AT3G22920

5 of 13

Yes

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (14)

Scer\CPR6

10 of 13

Yes

Scer\CPR7

5 of 13

Yes

4 of 13

4 of 13

3 of 13

3 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (12)

Spom\wis2

9 of 12

Yes

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (2)

Ecol\ppiA

3 of 11

Yes

Ecol\ppiB

3 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Cyp40. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (30)

7 of 13

7 of 13

7 of 13

7 of 13

6 of 13

6 of 13

5 of 13

5 of 13

5 of 13

4 of 13

4 of 13

4 of 13

3 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

shu

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

zda

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PPID; peptidylprolyl isomerase D

12 of 14

601753

NKTR; natural killer cell triggering receptor

5 of 14

161565

PPIA; peptidylprolyl isomerase A

5 of 14

123840

PPIAL4A; peptidylprolyl isomerase A like 4A

5 of 14

PPIAL4C; peptidylprolyl isomerase A like 4C

5 of 14

PPIAL4D; peptidylprolyl isomerase A like 4D

5 of 14

PPIAL4E; peptidylprolyl isomerase A like 4E

5 of 14

608608

PPIAL4F; peptidylprolyl isomerase A like 4F

5 of 14

PPIAL4G; peptidylprolyl isomerase A like 4G

5 of 14

PPIAL4H; peptidylprolyl isomerase A like 4H

5 of 14

PPIB; peptidylprolyl isomerase B

5 of 14

123841

OSTEOGENESIS IMPERFECTA, TYPE IX; OI9

osteogenesis imperfecta type 9

PPIC; peptidylprolyl isomerase C

5 of 14

123842

PPIG; peptidylprolyl isomerase G

5 of 14

606093

PPIF; peptidylprolyl isomerase F

4 of 14

604486

PPIE; peptidylprolyl isomerase E

3 of 14

602435

PPIH; peptidylprolyl isomerase H

3 of 14

606095

PPIL1; peptidylprolyl isomerase like 1

3 of 14

601301

PONTOCEREBELLAR HYPOPLASIA, TYPE 14; PCH14

pontocerebellar hypoplasia type 14

PPIL3; peptidylprolyl isomerase like 3

3 of 14

615811

PPIL6; peptidylprolyl isomerase like 6

3 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Cyp40 - AGO1

anti tag coimmunoprecipitation, western blot

(Iki et al., 2020)

Cyp40 - AGO2

anti tag coimmunoprecipitation, western blot, proximity-dependent biotin identification, pull down

(Iki et al., 2023, Iki et al., 2020)

Cyp40 - Hsp83

anti tag coimmunoprecipitation, western blot

(Iki et al., 2020)

Cyp40 - aub

proximity-dependent biotin identification, pull down, western blot

(Iki et al., 2023)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0036020

MIST (protein-protein) - An integrated Molecular Interaction Database

39121

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-31

Cytogenetic map

67C2-67C3

Sequence location

3L:9,628,676..9,631,795 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

67C2-67C3

Limits computationally determined from genome sequence between P{EP}Hsp26^EP3336&P{EP}Hsp26^EP3315 and P{PZ}fry⁰²²⁴⁰

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-31

(FlyBase, 2016)

3-23.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

94386

w^*; TI{CRIMIC.TG4.0}Cyp40^{CR60341-TG4.0}

24728

w¹¹¹⁸; Mi{ET1}Or67b^MB04909 Cyp40^MB04909

Kyoto

104692

y^* w^*; P{GawB}Cyp40^NP4480 / TM6, P{UAS-lacZ.UW23-1}UW23-1

NIG-Fly

8336R-3

P{NIG.8336R}3

VDRC

v23729

w¹¹¹⁸; P{GD13759}v23729

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (29)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH06403

Other clones

DPiM_GH06403

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0036020

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0036020

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Iki et al., 2020)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Cyp40 CG8336

(Iki et al., 2020)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CG8336

(Iki et al., 2020, Japanese National Institute of Genetics, 2012.5.21, Varma and Mishra, 2011, Rollmann et al., 2010, Telonis-Scott et al., 2009)

Cyp40

(Kang et al., 2025, Iki et al., 2020, Gene Disruption Project members, 2018-)

cyp40

(Iki et al., 2023)

Name Synonyms

Cyclophilin 40

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 45 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39121

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VT21

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VT21

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VT21

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0036020

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39121/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0036020

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0036020

FlyMine - An integrated database for Drosophila genomics

FBgn0036020

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG8336

MARRVEL_MODEL - MARRVEL (model organism gene)

39121

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0036020

DroID - A comprehensive database of gene and protein interactions.

FBgn0036020

DRSC - Results frm RNAi screens

FBgn0036020

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036020

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0036020

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8336

Flygut - An atlas of the Drosophila adult midgut

FBgn0036020

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007008

MIST (protein-protein) - An integrated Molecular Interaction Database

39121

References (32)

The following external sites may use different assemblies or annotations than FlyBase.

3.35

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