FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Cyp1
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General Information
Symbol
Dmel\Cyp1
Species
D. melanogaster
Name
Cyclophilin 1
Annotation Symbol
CG9916
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004432
Gene Model Status
Current
Stock Availability
17 publicly available
Enzyme Name (EC)
peptidylprolyl isomerase (5.2.1.8)
Gene Summary
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (UniProt, P25007)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Cyp-1, Cpy1

Key Links
Genomic Location
Cytogenetic map
14B9-14B12
Sequence location
Recombination map
1-53
RefSeq locus
NC_004354 REGION:16317673..16320370
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables cyclosporin A binding
inferred from biological aspect of ancestor with PANTHER:PTN008511653
(GO Reference Genome Project, 2011-)
enables peptidyl-prolyl cis-trans isomerase activity
inferred from sequence or structural similarity
(Stamnes et al., 1991)
inferred from electronic annotation with InterPro:IPR002130, InterPro:IPR020892
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN008511653
(GO Reference Genome Project, 2011-)
Biological Process (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in response to oxidative stress
inferred from mutant phenotype
(Kim et al., 2018)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in protein folding
inferred from biological aspect of ancestor with PANTHER:PTN008511653
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR020892
(InterPro Project Members, 2004-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from high throughput direct assay
(Lee et al., 2014)
located_in mitochondrion
inferred from mutant phenotype
(Kim et al., 2018)
located_in nucleus
inferred from high throughput direct assay
(Lee et al., 2014)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN008511653
(GO Reference Genome Project, 2011-)
located_in cytosol
inferred from sequence or structural similarity
(Stamnes et al., 1991)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. (P25007)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
peptidyl-prolyl cis-trans isomerase activity
[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) (5.2.1.8)
RHEA 16237:
Summaries
Gene Group (FlyBase)
CYCLOPHILINS -
Cyclophilins are a class of evolutionary conserved peptidyl prolyl cis/trans isomerases. In vertebrates, they form binary complexes with their ligand, cyclosporine A, and are involved in key biochemical processes including protein folding, receptor signalling, protein trafficking, and transcription. Cyclophilins are characterized by the presence of a 'Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain' (IPR002130). (Adapted from PMID:25986569.)
Protein Function (UniProtKB)
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
(UniProt, P25007)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Cyp1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P25007)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.48

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Cyp1-RA
FBtr0074238
NM_078642
1227
227
Additional Transcript Data and Comments
Reported size (kB)

1.0, 0.7 (unknown)

(Stamnes et al., 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Cyp1-PA
FBpp0074017
24.7
227
9.71
P25007
NP_523366
AAF48589
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cyp1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.06

Transcript Expression
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
wing disc
(Santaren et al., 1993)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from high throughput direct assay
(Lee et al., 2014)
located_in mitochondrion
inferred from mutant phenotype
(Kim et al., 2018)
located_in nucleus
inferred from high throughput direct assay
(Lee et al., 2014)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cyp1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cyp1
Transgenic constructs containing regulatory region of Cyp1
Aberrations (Deficiencies and Duplications) ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (24)
Hsap\PPIF
12 of 14
Yes
No
1  
Hsap\PPIA
7 of 14
No
Yes
1  
Hsap\PPIAL4A
6 of 14
No
Yes
Hsap\PPIAL4C
6 of 14
No
Yes
Hsap\PPIAL4D
6 of 14
No
Yes
Hsap\PPIAL4E
6 of 14
No
Yes
Hsap\PPIAL4F
6 of 14
No
Yes
Hsap\PPIAL4G
6 of 14
No
Yes
Hsap\PPIAL4H
6 of 14
No
Yes
Hsap\PPIB
5 of 14
No
No
Hsap\PPIC
5 of 14
No
No
Hsap\NKTR
4 of 14
No
No
Hsap\PPID
4 of 14
No
No
Hsap\PPIE
4 of 14
No
No
Hsap\PPIG
4 of 14
No
No
Hsap\PPIH
3 of 14
No
No
Hsap\PPIL1
3 of 14
No
No
Hsap\PPIL3
3 of 14
No
No
1  
Hsap\CWC27
2 of 14
No
No
1  
Hsap\PPIL2
2 of 14
No
No
Hsap\PPIL4
2 of 14
No
No
Hsap\PPIL6
2 of 14
No
No
Hsap\RANBP2
2 of 14
No
No
Hsap\PPWD1
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (20)
Rnor\Ppif
12 of 14
Yes
No
Rnor\Ppial4g
7 of 14
No
Yes
Rnor\Ppial4d
6 of 14
No
Yes
Rnor\Ppia
6 of 14
No
Yes
Rnor\LOC100911252
5 of 14
No
Yes
Rnor\Ppib
5 of 14
No
No
Rnor\Ppic
5 of 14
No
No
Rnor\Ppid
4 of 14
No
No
Rnor\Ppie
4 of 14
No
No
Rnor\Ppig
4 of 14
No
No
Rnor\Nktr
2 of 14
No
No
Rnor\Ppidl1
2 of 14
No
No
Rnor\Ppih
2 of 14
No
No
Rnor\Ppil3
2 of 14
No
No
Rnor\Ppil6
2 of 14
No
No
Rnor\Ranbp2
2 of 14
No
No
Rnor\Cwc27
1 of 14
No
No
Rnor\LOC100909955
1 of 14
No
Yes
Rnor\Ppil1
1 of 14
No
No
Rnor\Ppil2
1 of 14
No
No
Mus musculus (laboratory mouse) (18)
Mmus\Ppif
12 of 14
Yes
No
Mmus\Ppia
7 of 14
No
Yes
Mmus\Ppib
5 of 14
No
No
Mmus\Ppic
5 of 14
No
No
Mmus\Nktr
4 of 14
No
No
Mmus\Ppid
4 of 14
No
No
Mmus\Ppie
3 of 14
No
No
Mmus\Ppig
3 of 14
No
No
Mmus\Ppih
3 of 14
No
No
Mmus\Ppil1
2 of 14
No
No
Mmus\Ppil3
2 of 14
No
No
Mmus\Ppil6
2 of 14
No
No
Mmus\Ranbp2
2 of 14
No
No
Mmus\Cwc27
1 of 14
No
No
Mmus\Gm7879
1 of 14
No
No
Mmus\Gm12728
1 of 14
No
Yes
Mmus\Ppil2
1 of 14
No
No
Mmus\Ppil4
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (23)
Xtro\ppif
10 of 13
Yes
Yes
Xtro\ppia
7 of 13
No
Yes
Xtro\LOC100488106
5 of 13
No
Yes
Xtro\ppic
4 of 13
No
No
Xtro\nktr
3 of 13
No
No
Xtro\ppid
3 of 13
No
No
Xtro\ppig
3 of 13
No
No
Xtro\ppih
2 of 13
No
No
Xtro\zar1l
2 of 13
No
Yes
Xtro\crot
1 of 13
No
No
Xtro\cthrc1
1 of 13
No
No
Xtro\gpx8
1 of 13
No
No
Xtro\hsd3b7
1 of 13
No
No
Xtro\ipmk
1 of 13
No
No
Xtro\LOC100496569
1 of 13
No
Yes
Xtro\madd
1 of 13
No
No
Xtro\ppib
1 of 13
No
No
Xtro\ppie
1 of 13
No
No
Xtro\ppil1
1 of 13
No
No
Xtro\ppil2
1 of 13
No
No
Xtro\ppil3
1 of 13
No
No
Xtro\ppil6
1 of 13
No
Yes
Xtro\ppwd1
1 of 13
No
No
Danio rerio (Zebrafish) (19)
Drer\ppiaa
10 of 14
Yes
No
Drer\ppifb
10 of 14
Yes
Yes
Drer\ppiab
7 of 14
No
Yes
Drer\ppifa
6 of 14
No
Yes
Drer\ppib
5 of 14
No
No
Drer\LOC100333141
4 of 14
No
No
Drer\nktr
4 of 14
No
No
Drer\ppid
4 of 14
No
No
Drer\ppig
4 of 14
No
No
Drer\ppie
3 of 14
No
No
Drer\ppih
2 of 14
No
No
Drer\ppil3
2 of 14
No
No
Drer\ppil6
2 of 14
No
No
Drer\cwc27
1 of 14
No
No
Drer\ftr52p
1 of 14
No
No
Drer\ppil1
1 of 14
No
No
Drer\ppil2
1 of 14
No
No
Drer\ppil4
1 of 14
No
No
Drer\ranbp2
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (19)
Cele\cyn-1
12 of 14
Yes
Yes
Cele\cyn-3
12 of 14
Yes
Yes
Cele\cyn-7
12 of 14
Yes
Yes
Cele\cyn-2
11 of 14
No
Yes
Cele\cyn-5
5 of 14
No
No
Cele\cyn-6
5 of 14
No
No
Cele\T22F3.12
5 of 14
No
Yes
Cele\cyn-8
4 of 14
No
No
Cele\cyn-9
4 of 14
No
No
Cele\cyn-11
3 of 14
No
No
Cele\cyn-12
3 of 14
No
No
Cele\cyn-4
2 of 14
No
No
Cele\cyn-10
2 of 14
No
No
Cele\cyn-13
2 of 14
No
No
Cele\cyn-16
2 of 14
No
No
Cele\Y17G9B.4
2 of 14
No
No
Cele\ZC250.5
2 of 14
No
Yes
Cele\cyn-15
1 of 14
No
No
Cele\sig-7
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (13)
Agam\AgaP_AGAP000462
11 of 12
Yes
Yes
Agam\AgaP_AGAP007088
5 of 12
No
No
Agam\AgaP_AGAP003265
4 of 12
No
No
Agam\AgaP_AGAP009991
4 of 12
No
No
Agam\AgaP_AGAP002952
3 of 12
No
No
Agam\AgaP_AGAP007392
3 of 12
No
No
Agam\AgaP_AGAP009810
3 of 12
No
No
Agam\AgaP_AGAP009996
3 of 12
No
No
Agam\AgaP_AGAP012376
3 of 12
No
No
Agam\AgaP_AGAP007704
2 of 12
No
No
Agam\AgaP_AGAP001987
1 of 12
No
No
Agam\AgaP_AGAP008136
1 of 12
No
No
Agam\AgaP_AGAP008660
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (29)
Atha\AT2G21130
11 of 13
Yes
Yes
Atha\ROC1
11 of 13
Yes
Yes
Atha\ROC2
11 of 13
Yes
Yes
Atha\ROC3
11 of 13
Yes
Yes
Atha\ROC5
11 of 13
Yes
Yes
Atha\AT3G55920
7 of 13
No
Yes
Atha\CYP5
7 of 13
No
No
Atha\ROC7
7 of 13
No
Yes
Atha\AT3G22920
5 of 13
No
Yes
Atha\AT3G63400
5 of 13
No
No
Atha\AT4G34960
5 of 13
No
Yes
Atha\Pnsl5
5 of 13
No
No
Atha\ROC4
5 of 13
No
No
Atha\AT4G32420
4 of 13
No
No
Atha\SQN
4 of 13
No
No
Atha\AT1G01940
3 of 13
No
No
Atha\AT2G36130
3 of 13
No
No
Atha\AT2G38730
3 of 13
No
No
Atha\AT1G26940
2 of 13
No
No
Atha\AT1G74070
2 of 13
No
Yes
Atha\AT4G33060
2 of 13
No
No
Atha\AT5G35100
2 of 13
No
Yes
Atha\CYP59
2 of 13
No
No
Atha\PUB49
2 of 13
No
No
Atha\AT1G53780
1 of 13
No
No
Atha\AT3G15520
1 of 13
No
Yes
Atha\ATE1
1 of 13
No
No
Atha\CYP38
1 of 13
No
Yes
Atha\CYP71
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (9)
Scer\CPR1
11 of 13
Yes
Yes
Scer\CPR3
7 of 13
No
Yes
Scer\CPR2
4 of 13
No
No
Scer\CPR5
4 of 13
No
No
Scer\CPR6
4 of 13
No
No
Scer\CPR7
4 of 13
No
No
Scer\CPR4
1 of 13
No
No
Scer\CPR8
1 of 13
No
No
Scer\CWC27
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (8)
Spom\ppi1
10 of 12
Yes
Yes
Spom\cyp4
4 of 12
No
No
Spom\wis2
3 of 12
No
No
Spom\cyp1
2 of 12
No
No
Spom\cyp3
2 of 12
No
No
Spom\cyp7
1 of 12
No
No
Spom\cyp8
1 of 12
No
No
Spom\rct1
1 of 12
No
No
Escherichia coli (enterobacterium) (2)
Ecol\ppiA
4 of 11
Yes
No
Ecol\ppiB
4 of 11
Yes
No
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Cyp1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (18)
CG7768
12 of 13
CG2852
8 of 13
CG17266
7 of 13
Cyp40
7 of 13
Moca-cyp
7 of 13
ninaA
7 of 13
CG11777
6 of 13
cyp33
6 of 13
Cypl
6 of 13
CG7747
4 of 13
CG10907
4 of 13
CG3492
3 of 13
CG3511
3 of 13
Ppil4
3 of 13
CG5071
2 of 13
CG15767
2 of 13
CG30350
2 of 13
CG32236
2 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Cyp1EP1073
    ameliorates  Parkinson's disease 7
    modeled by dj-1βex54
    (Kim et al., 2018)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    PPIF; peptidylprolyl isomerase F
    12 of 14
    604486
         
        PPIA; peptidylprolyl isomerase A
        7 of 14
        123840
             
            PPIAL4A; peptidylprolyl isomerase A like 4A
            6 of 14
                PPIAL4C; peptidylprolyl isomerase A like 4C
                6 of 14
                    PPIAL4D; peptidylprolyl isomerase A like 4D
                    6 of 14
                        PPIAL4E; peptidylprolyl isomerase A like 4E
                        6 of 14
                        608608
                            PPIAL4F; peptidylprolyl isomerase A like 4F
                            6 of 14
                                PPIAL4G; peptidylprolyl isomerase A like 4G
                                6 of 14
                                    PPIAL4H; peptidylprolyl isomerase A like 4H
                                    6 of 14
                                        PPIB; peptidylprolyl isomerase B
                                        5 of 14
                                        123841
                                        PPIC; peptidylprolyl isomerase C
                                        5 of 14
                                        123842
                                            NKTR; natural killer cell triggering receptor
                                            4 of 14
                                            161565
                                                PPID; peptidylprolyl isomerase D
                                                4 of 14
                                                601753
                                                    PPIE; peptidylprolyl isomerase E
                                                    4 of 14
                                                    602435
                                                        PPIG; peptidylprolyl isomerase G
                                                        4 of 14
                                                        606093
                                                            PPIH; peptidylprolyl isomerase H
                                                            3 of 14
                                                            606095
                                                                PPIL1; peptidylprolyl isomerase like 1
                                                                3 of 14
                                                                601301
                                                                PPIL3; peptidylprolyl isomerase like 3
                                                                3 of 14
                                                                615811
                                                                     
                                                                    Functional Complementation Data
                                                                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                                                    Interactions
                                                                    Summary of Physical Interactions
                                                                    Summary of Genetic Interactions
                                                                    Interaction Browsers
                                                                    Starting gene(s)
                                                                    Interaction type
                                                                    Interacting gene(s)
                                                                    Reference
                                                                    Starting gene(s)
                                                                    Interaction type
                                                                    Interacting gene(s)
                                                                    Reference
                                                                    External Data
                                                                    Linkouts
                                                                    BioGRID - A database of protein and genetic interactions.
                                                                    DroID - A comprehensive database of gene and protein interactions.
                                                                    MIST (protein-protein) - An integrated Molecular Interaction Database
                                                                    Pathways
                                                                    Signaling Pathways (FlyBase)
                                                                    Metabolic Pathways
                                                                    FlyBase
                                                                    External Links
                                                                    External Data
                                                                    Linkouts
                                                                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                                    Class of Gene
                                                                    Genomic Location and Detailed Mapping Data
                                                                    Chromosome (arm)
                                                                    X
                                                                    Recombination map
                                                                    1-53
                                                                    Cytogenetic map
                                                                    14B9-14B12
                                                                    Sequence location
                                                                    FlyBase Computed Cytological Location
                                                                    Cytogenetic map
                                                                    Evidence for location
                                                                    14B9-14B12
                                                                    Limits computationally determined from genome sequence between P{EP}kat80EP620&P{EP}cazEP1564 and P{EP}Cyp1EP1073&P{EP}Dsp1EP355
                                                                    Experimentally Determined Cytological Location
                                                                    Cytogenetic map
                                                                    Notes
                                                                    References
                                                                    14B11-14B12
                                                                    (determined by in situ hybridisation)
                                                                    (Rutherford, 1996.11.4)
                                                                    Experimentally Determined Recombination Data
                                                                    Location

                                                                    1-53

                                                                    (FlyBase, 2016)

                                                                    1-54.5

                                                                    (Comeron et al., 2012)
                                                                    Left of (cM)
                                                                    Right of (cM)
                                                                    Notes
                                                                    Stocks and Reagents
                                                                    Stocks (17)
                                                                    Genomic Clones (19)
                                                                    cDNA Clones (307)
                                                                     

                                                                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                                                    cDNA clones, fully sequenced
                                                                    BDGP DGC clones
                                                                    Other clones
                                                                      Drosophila Genomics Resource Center cDNA clones

                                                                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                                                      cDNA Clones, End Sequenced (ESTs)
                                                                      BDGP DGC clones
                                                                      Other clones
                                                                      RNAi and Array Information
                                                                      Linkouts
                                                                      DRSC - Results frm RNAi screens
                                                                      Antibody Information
                                                                      Laboratory Generated Antibodies
                                                                       
                                                                      Commercially Available Antibodies
                                                                       
                                                                      Cell Line Information
                                                                      Publicly Available Cell Lines
                                                                       
                                                                        Other Stable Cell Lines
                                                                         
                                                                          Other Comments

                                                                          "Gene order: In direction of increasing cytology: Cyp1- nonA?" was stated as revision.

                                                                          (Rutherford, 1996.11.4)

                                                                          Identified in 2D gels of CMW W2 wing imaginal disc cell (spot NEPHGE/16).

                                                                          (Santaren et al., 1993)

                                                                          Cyp1 is expressed throughout development and produces two alternatively processed forms.

                                                                          (Stamnes et al., 1991)
                                                                          Relationship to Other Genes
                                                                          Source for database merge of

                                                                          Source for merge of: Cyp1 BcDNA:GM09255

                                                                          (FlyBase, 1996-)
                                                                          Additional comments

                                                                          Source for merge of Cyp1 BcDNA:GM09255 was a shared cDNA ( date:030728 ).

                                                                          (FlyBase, 1996-)
                                                                          Nomenclature History
                                                                          Source for database identify of
                                                                          Nomenclature comments
                                                                          Etymology
                                                                          Synonyms and Secondary IDs (14)
                                                                          Datasets (0)
                                                                          Study focus (0)
                                                                          Experimental Role
                                                                          Project
                                                                          Project Type
                                                                          Title
                                                                          Study result (0)
                                                                          Result
                                                                          Result Type
                                                                          Title
                                                                          External Crossreferences and Linkouts ( 45 )
                                                                          Sequence Crossreferences
                                                                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                                                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                                          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                                                          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                                                          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                                                          Other crossreferences
                                                                          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                                                          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                                                          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                                                          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                                                          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                                                          FlyMine - An integrated database for Drosophila genomics
                                                                          InterPro - A database of protein families, domains and functional sites
                                                                          KEGG Genes - Molecular building blocks of life in the genomic space.
                                                                          MARRVEL_MODEL - MARRVEL (model organism gene)
                                                                          Linkouts
                                                                          BioGRID - A database of protein and genetic interactions.
                                                                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                                                          DroID - A comprehensive database of gene and protein interactions.
                                                                          DRSC - Results frm RNAi screens
                                                                          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                                                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                                                          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                                                          Flygut - An atlas of the Drosophila adult midgut
                                                                          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                                                          MIST (protein-protein) - An integrated Molecular Interaction Database
                                                                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                                          References (96)