FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ecdΔ
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General Information
Symbol
Dmel\ecdΔ
Species
D. melanogaster
Name
FlyBase ID
FBal0367048
Feature type
allele
Associated gene
Dmel\ecd
Associated Insertion(s)
TI{TI}ecdΔ
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Erkelenz et al., 2021)
Mutagen
CRISPR/Cas9
(Erkelenz et al., 2021)
Progenitor genotype
Associated Insertion(s)
TI{TI}ecdΔ
Cytology
Description

Frame-shifting indel (including a nucleotide insertion and a 1034bp deletion) within ecd.

(Erkelenz et al., 2021)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3L:2,264,663..2,265,705 [-]
Comment:

1043bp deletion and insertion of 9bp starting at ecd codon 24 leads to a frameshift and a truncated protein.

Inserted_sequence:

GGAACCTTC

(Erkelenz et al., 2021)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In contrast to controls, ecdΔ homozygous clones in mosaic third instar larval eye-antennal discs are very rare, presented as individual cells within the differentiated part of the eye primordium. ecdΔ homozygous clones remain smaller in the adult eye.

      (Erkelenz et al., 2021)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ecdΔ
      (Erkelenz et al., 2021)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)