FlyBase Allele Report: Dmel\Nup358[A]

General Information

Symbol

Dmel\Nup358^A

Species

D. melanogaster

Name

FlyBase ID

FBal0371376

Feature type

allele

Associated gene

Dmel\Nup358

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Chen et al., 2021)

gene targeting by homologous recombination

(Chen et al., 2021)

Progenitor genotype

Cytology

Description

69bp deletion in the endogenous Nup358 locus. This results in the deletion of 23 codons that are specific to the B isoform, resulting in a locus that only expresses the A isoform.

(Chen et al., 2021)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | P-stage | recessive

(Chen et al., 2021)

lethal - all die during P-stage

(Chen et al., 2021)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Nup358^A has abnormal developmental rate | recessive | P-stage phenotype, suppressible by Nup358::RanGAP^A.Δ

(Chen et al., 2021)

Nup358^A has abnormal developmental rate | recessive | P-stage phenotype, suppressible by Nup358::RanGAP^A.WT

(Chen et al., 2021)

NOT suppressed by

Statement

Reference

Nup358^A has abnormal developmental rate | recessive | P-stage phenotype, non-suppressible by Nup358::RanGAP^A.ΔDA

(Chen et al., 2021)

Nup358^A has abnormal developmental rate | recessive | P-stage phenotype, non-suppressible by Nup358::RanGAP^A.ΔRA

(Chen et al., 2021)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Nup358^A is rescued by Nup358^+tCa

(Chen et al., 2021)

Nup358^A is rescued by Nup358^tA-69bp

(Chen et al., 2021)

Not rescued by

Nup358^A is not rescued by Nup358^tA

(Chen et al., 2021)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Nup358^A

ranbp2A

(Chen et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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