FlyBase Allele Report: Dmel\dind[UAS.Tag:FLAG]

General Information

Symbol

Dmel\dind^UAS.Tag:FLAG

Species

D. melanogaster

Name

FlyBase ID

FBal0371832

Feature type

allele

Associated gene

Dmel\dind

Associated Insertion(s)

Carried in Construct

P{UAS-flag.dind}

Key Links

Transgenic product class

cDNA

(Zhao et al., 2022)

wild_type

(Zhao et al., 2022)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Zhao et al., 2022)

wild_type

(Zhao et al., 2022)

Mutagen

in vitro construct

(Zhao et al., 2022)

Progenitor genotype

Carried in construct

P{UAS-flag.dind}

Cytology

Description

UASt regulates expression of dind cDNA (LP22035) tagged at the N-terminus with Tag:FLAG.

(Zhao et al., 2022)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dind

Tagged with

Tag:FLAG

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | adult stage, with Scer\GAL4^esg.PU

(Ren et al., 2022, Zhao et al., 2022)

increased occurrence of cell division | adult stage, with Scer\GAL4^esg.PU

(Zhao et al., 2022)

Phenotype Manifest In

adult posterior midgut epithelium, with Scer\GAL4^esg.PU

(Ren et al., 2022, Zhao et al., 2022)

Detailed Description

Statement

Reference

Adulthood-only expression of dind^UAS.Tag:FLAG under the control of Scer\GAL4^esg.PU leads to an increase in the number of intestinal progenitors (esg-positive ISCs and EBs) and an increased in the mitotic index in the adult posterior midgut.

(Zhao et al., 2022)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

dind^UAS.Tag:FLAG, Scer\GAL4^esg.PU is a non-enhancer of decreased cell number | adult stage phenotype of CkIα^HMS02276, Scer\GAL4^esg.PU

(Ren et al., 2022)

dind^UAS.Tag:FLAG/Scer\GAL4^Act.PU is a non-enhancer of decreased cell number | adult stage | somatic clone phenotype of CkIIβ^A

(Ren et al., 2022)

dind^UAS.Tag:FLAG, Scer\GAL4^esg.PU is a non-enhancer of decreased cell number | adult stage phenotype of CkIIβ^HMS00058, Scer\GAL4^esg.PU

(Ren et al., 2022)

dind^UAS.Tag:FLAG/Scer\GAL4^Act.PU is a non-enhancer of decreased cell number | adult stage | somatic clone phenotype of CkIα^8B12

(Ren et al., 2022)

dind^UAS.Tag:FLAG/Scer\GAL4^Act5C.PI is a non-enhancer of decreased cell number | adult stage | somatic clone phenotype of Phb1²⁰

(Zhao et al., 2022)

dind^UAS.Tag:FLAG/Scer\GAL4^Act5C.PI is a non-enhancer of decreased cell number | adult stage | somatic clone phenotype of Phb2^Δ

(Zhao et al., 2022)

Suppressor of

Statement

Reference

dind^UAS.Tag:FLAG/Scer\GAL4^Act5C.PI is a suppressor | partially of decreased cell number | somatic clone | adult stage phenotype of Raf¹¹

(Zhao et al., 2022)

NOT Suppressor of

Statement

Reference

dind^UAS.Tag:FLAG, Scer\GAL4^esg.PU is a non-suppressor of decreased cell number | adult stage phenotype of CkIIβ^HMS00058, Scer\GAL4^esg.PU

(Ren et al., 2022)

dind^UAS.Tag:FLAG/Scer\GAL4^Act.PU is a non-suppressor of decreased cell number | somatic clone | adult stage phenotype of CkIα^8B12

(Ren et al., 2022)

dind^UAS.Tag:FLAG, Scer\GAL4^esg.PU is a non-suppressor of decreased cell number | adult stage phenotype of CkIα^HMS02276, Scer\GAL4^esg.PU

(Ren et al., 2022)

dind^UAS.Tag:FLAG/Scer\GAL4^Act.PU is a non-suppressor of decreased cell number | somatic clone | adult stage phenotype of CkIIβ^A

(Ren et al., 2022)

dind^UAS.Tag:FLAG/Scer\GAL4^Act5C.PI is a non-suppressor of decreased cell number | somatic clone | adult stage phenotype of Phb1²⁰

(Zhao et al., 2022)

dind^UAS.Tag:FLAG, Scer\GAL4^esg.PU is a non-suppressor of decreased cell number | adult stage phenotype of Phb1^HMS00702, Scer\GAL4^esg.PU

(Zhao et al., 2022)

dind^UAS.Tag:FLAG/Scer\GAL4^Act5C.PI is a non-suppressor of decreased cell number | somatic clone | adult stage phenotype of Phb2^Δ

(Zhao et al., 2022)

dind^UAS.Tag:FLAG, Scer\GAL4^esg.PU is a non-suppressor of decreased cell number | adult stage phenotype of Phb2^GD8538, Scer\GAL4^esg.PU

(Zhao et al., 2022)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

dind^UAS.Tag:FLAG, Scer\GAL4^esg.PU is a non-enhancer of adult posterior midgut epithelium phenotype of CkIα^HMS02276, Scer\GAL4^esg.PU

(Ren et al., 2022)

dind^UAS.Tag:FLAG/Scer\GAL4^Act.PU is a non-enhancer of adult posterior midgut epithelium | somatic clone phenotype of CkIIβ^A

(Ren et al., 2022)

dind^UAS.Tag:FLAG, Scer\GAL4^esg.PU is a non-enhancer of adult posterior midgut epithelium phenotype of CkIIβ^HMS00058, Scer\GAL4^esg.PU

(Ren et al., 2022)

dind^UAS.Tag:FLAG/Scer\GAL4^Act.PU is a non-enhancer of adult posterior midgut epithelium | somatic clone phenotype of CkIα^8B12

(Ren et al., 2022)

dind^UAS.Tag:FLAG/Scer\GAL4^Act5C.PI is a non-enhancer of adult posterior midgut epithelium | somatic clone phenotype of Phb1²⁰

(Zhao et al., 2022)

dind^UAS.Tag:FLAG/Scer\GAL4^Act5C.PI is a non-enhancer of adult posterior midgut epithelium | somatic clone phenotype of Phb2^Δ

(Zhao et al., 2022)

Suppressor of

Statement

Reference

dind^UAS.Tag:FLAG/Scer\GAL4^Act5C.PI is a suppressor | partially of adult posterior midgut epithelium | somatic clone phenotype of Raf¹¹

(Zhao et al., 2022)

NOT Suppressor of

Statement

Reference

dind^UAS.Tag:FLAG, Scer\GAL4^esg.PU is a non-suppressor of adult posterior midgut epithelium phenotype of CkIIβ^HMS00058, Scer\GAL4^esg.PU

(Ren et al., 2022)

dind^UAS.Tag:FLAG/Scer\GAL4^Act.PU is a non-suppressor of adult posterior midgut epithelium | somatic clone phenotype of CkIα^8B12

(Ren et al., 2022)

dind^UAS.Tag:FLAG, Scer\GAL4^esg.PU is a non-suppressor of adult posterior midgut epithelium phenotype of CkIα^HMS02276, Scer\GAL4^esg.PU

(Ren et al., 2022)

dind^UAS.Tag:FLAG/Scer\GAL4^Act.PU is a non-suppressor of adult posterior midgut epithelium | somatic clone phenotype of CkIIβ^A

(Ren et al., 2022)

dind^UAS.Tag:FLAG/Scer\GAL4^Act5C.PI is a non-suppressor of adult posterior midgut epithelium | somatic clone phenotype of Phb1²⁰

(Zhao et al., 2022)

dind^UAS.Tag:FLAG, Scer\GAL4^esg.PU is a non-suppressor of adult posterior midgut epithelium phenotype of Phb1^HMS00702, Scer\GAL4^esg.PU

(Zhao et al., 2022)

dind^UAS.Tag:FLAG/Scer\GAL4^Act5C.PI is a non-suppressor of adult posterior midgut epithelium | somatic clone phenotype of Phb2^Δ

(Zhao et al., 2022)

dind^UAS.Tag:FLAG, Scer\GAL4^esg.PU is a non-suppressor of adult posterior midgut epithelium phenotype of Phb2^GD8538, Scer\GAL4^esg.PU

(Zhao et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

dind^UAS.Tag:FLAG/Scer\GAL4^Act.PU rescues dind^Δ9

(Zhao et al., 2023)

dind^UAS.Tag:FLAG/Scer\GAL4^Act.PU rescues dind^Δ9

(Ren et al., 2022)

dind^UAS.Tag:FLAG/Scer\GAL4^Act5C.PI rescues dind^Δ66

(Zhao et al., 2022)

dind^UAS.Tag:FLAG/Scer\GAL4^Act5C.PI rescues dind^Δ9

(Zhao et al., 2022)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

dind^UAS.Tag:FLAG

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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