FlyBase Allele Report: Dmel\Phb2[Δ]

General Information

Symbol

Dmel\Phb2^Δ

Species

D. melanogaster

Name

FlyBase ID

FBal0371839

Feature type

allele

Associated gene

Dmel\Phb2

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Zhao et al., 2022)

Mutagen

CRISPR/Cas9

(Zhao et al., 2022)

Progenitor genotype

Cytology

Description

A 1.3 kb deletion from the 5' UTR to the third coding exon.

(Zhao et al., 2022)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | adult stage | somatic clone

(Zhao et al., 2022)

Phenotype Manifest In

adult posterior midgut epithelium | somatic clone

(Zhao et al., 2022)

Detailed Description

Statement

Reference

Adulthood-induced Phb2^Δ clones in the intestine contain only one cell. upon DSS-induced regeneration clones are also smaller.

(Zhao et al., 2022)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Phb2^Δ has decreased cell number | adult stage | somatic clone phenotype, non-enhanceable by Scer\GAL4^esg.PU/Hsap\PHB1^UAS.Tag:V5

(Zhao et al., 2022)

Phb2^Δ has decreased cell number | adult stage | somatic clone phenotype, non-enhanceable by Scer\GAL4^Act5C.PI/bmm^UAS.mCherry

(Zhao et al., 2022)

Phb2^Δ has decreased cell number | adult stage | somatic clone phenotype, non-enhanceable by scu^UAS.Exel/Scer\GAL4^Act5C.PI

(Zhao et al., 2022)

Phb2^Δ has decreased cell number | adult stage | somatic clone phenotype, non-enhanceable by dind^UAS.Tag:FLAG/Scer\GAL4^Act5C.PI

(Zhao et al., 2022)

Phb2^Δ has decreased cell number | adult stage | somatic clone phenotype, non-enhanceable by Scer\GAL4^Act5C.PI/Phb1^UAS.Tag:V5

(Zhao et al., 2022)

Phb2^Δ has decreased cell number | adult stage | somatic clone phenotype, non-enhanceable by Atg1^HMS02750/Scer\GAL4^Act5C.PI

(Zhao et al., 2022)

Phb2^Δ has decreased cell number | adult stage | somatic clone phenotype, non-enhanceable by Scer\GAL4^Act5C.PI/Atg5^HMS01244

(Zhao et al., 2022)

Suppressed by

Statement

Reference

Phb2^Δ has decreased cell number | somatic clone | adult stage phenotype, suppressible | partially by Scer\GAL4^Act5C.PI/Hsap\PHB2^UAS.Tag:V5

(Zhao et al., 2022)

Phb2^Δ has decreased cell number | somatic clone | adult stage phenotype, suppressible | partially by E2f1^UAS.cNa/Scer\GAL4^Act5C.PI

(Zhao et al., 2022)

NOT suppressed by

Statement

Reference

Phb2^Δ has decreased cell number | somatic clone | adult stage phenotype, non-suppressible by Scer\GAL4^esg.PU/Hsap\PHB1^UAS.Tag:V5

(Zhao et al., 2022)

Phb2^Δ has decreased cell number | somatic clone | adult stage phenotype, non-suppressible by Atg1^HMS02750/Scer\GAL4^Act5C.PI

(Zhao et al., 2022)

Phb2^Δ has decreased cell number | somatic clone | adult stage phenotype, non-suppressible by Scer\GAL4^Act5C.PI/Atg5^HMS01244

(Zhao et al., 2022)

Phb2^Δ has decreased cell number | somatic clone | adult stage phenotype, non-suppressible by Scer\GAL4^Act5C.PI/bmm^UAS.mCherry

(Zhao et al., 2022)

Phb2^Δ has decreased cell number | somatic clone | adult stage phenotype, non-suppressible by scu^UAS.Exel/Scer\GAL4^Act5C.PI

(Zhao et al., 2022)

Phb2^Δ has decreased cell number | somatic clone | adult stage phenotype, non-suppressible by dind^UAS.Tag:FLAG/Scer\GAL4^Act5C.PI

(Zhao et al., 2022)

Phb2^Δ has decreased cell number | somatic clone | adult stage phenotype, non-suppressible by Scer\GAL4^Act5C.PI/Phb1^UAS.Tag:V5

(Zhao et al., 2022)

Suppressor of

Statement

Reference

Phb2^Δ/Phb2^Δ is a suppressor of increased cell number | somatic clone | adult stage phenotype of Scer\GAL4^Act5C.PI, hop^Tum.UAS

(Zhao et al., 2022)

Phb2^Δ/Phb2^Δ is a suppressor of increased cell number | somatic clone | adult stage phenotype of Raf^UAS.F179, Scer\GAL4^Act5C.PI

(Zhao et al., 2022)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Phb2^Δ has adult posterior midgut epithelium | somatic clone phenotype, non-enhanceable by Scer\GAL4^esg.PU/Hsap\PHB1^UAS.Tag:V5

(Zhao et al., 2022)

Phb2^Δ has adult posterior midgut epithelium | somatic clone phenotype, non-enhanceable by Scer\GAL4^Act5C.PI/bmm^UAS.mCherry

(Zhao et al., 2022)

Phb2^Δ has adult posterior midgut epithelium | somatic clone phenotype, non-enhanceable by scu^UAS.Exel/Scer\GAL4^Act5C.PI

(Zhao et al., 2022)

Phb2^Δ has adult posterior midgut epithelium | somatic clone phenotype, non-enhanceable by dind^UAS.Tag:FLAG/Scer\GAL4^Act5C.PI

(Zhao et al., 2022)

Phb2^Δ has adult posterior midgut epithelium | somatic clone phenotype, non-enhanceable by Scer\GAL4^Act5C.PI/Phb1^UAS.Tag:V5

(Zhao et al., 2022)

Phb2^Δ has adult posterior midgut epithelium | somatic clone phenotype, non-enhanceable by Atg1^HMS02750/Scer\GAL4^Act5C.PI

(Zhao et al., 2022)

Phb2^Δ has adult posterior midgut epithelium | somatic clone phenotype, non-enhanceable by Scer\GAL4^Act5C.PI/Atg5^HMS01244

(Zhao et al., 2022)

Suppressed by

Statement

Reference

Phb2^Δ has adult posterior midgut epithelium | somatic clone phenotype, suppressible | partially by Scer\GAL4^Act5C.PI/Hsap\PHB2^UAS.Tag:V5

(Zhao et al., 2022)

Phb2^Δ has adult posterior midgut epithelium | somatic clone phenotype, suppressible | partially by E2f1^UAS.cNa/Scer\GAL4^Act5C.PI

(Zhao et al., 2022)

NOT suppressed by

Statement

Reference

Phb2^Δ has adult posterior midgut epithelium | somatic clone phenotype, non-suppressible by Scer\GAL4^esg.PU/Hsap\PHB1^UAS.Tag:V5

(Zhao et al., 2022)

Phb2^Δ has adult posterior midgut epithelium | somatic clone phenotype, non-suppressible by Scer\GAL4^Act5C.PI/bmm^UAS.mCherry

(Zhao et al., 2022)

Phb2^Δ has adult posterior midgut epithelium | somatic clone phenotype, non-suppressible by scu^UAS.Exel/Scer\GAL4^Act5C.PI

(Zhao et al., 2022)

Phb2^Δ has adult posterior midgut epithelium | somatic clone phenotype, non-suppressible by dind^UAS.Tag:FLAG/Scer\GAL4^Act5C.PI

(Zhao et al., 2022)

Phb2^Δ has adult posterior midgut epithelium | somatic clone phenotype, non-suppressible by Scer\GAL4^Act5C.PI/Phb1^UAS.Tag:V5

(Zhao et al., 2022)

Phb2^Δ has adult posterior midgut epithelium | somatic clone phenotype, non-suppressible by Scer\GAL4^Act5C.PI/Atg5^HMS01244

(Zhao et al., 2022)

Phb2^Δ has adult posterior midgut epithelium | somatic clone phenotype, non-suppressible by Atg1^HMS02750/Scer\GAL4^Act5C.PI

(Zhao et al., 2022)

Suppressor of

Statement

Reference

Phb2^Δ/Phb2^Δ is a suppressor of adult posterior midgut epithelium | somatic clone phenotype of Scer\GAL4^Act5C.PI, hop^Tum.UAS

(Zhao et al., 2022)

Phb2^Δ/Phb2^Δ is a suppressor of adult posterior midgut epithelium | somatic clone phenotype of Raf^UAS.F179, Scer\GAL4^Act5C.PI

(Zhao et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Phb2^Δ is rescued by Phb2^UAS.Tag:FLAG/Scer\GAL4^Act5C.PI

(Zhao et al., 2022)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Phb2^Δ

(Zhao et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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