FlyBase Allele Report: Dmel\peo[1]

General Information

Symbol

Dmel\peo¹

Species

D. melanogaster

Name

FlyBase ID

FBal0374465

Feature type

allele

Associated gene

Dmel\peo

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - molecular evidence

Mutagen

IR-hybrid dysgenesis

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Cenci et al., 2015)

Mutagen

IR-hybrid dysgenesis

(Cenci et al., 2015)

Progenitor genotype

Cytology

Description

No nonsense, frameshift, splice-site or missense mutation has been found in the coding sequence of the CG10536 annotation. No I-element insertion has been found within 2kb upstream of the ATG codon.

(Cenci et al., 2015)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle | larval stage

(Cenci et al., 2015)

abnormal mitotic cell cycle | larval stage (with Df(2R)221)

(Cenci et al., 2015)

abnormal mitotic cell cycle | larval stage (with Df(2R)520)

(Cenci et al., 2015)

abnormal mitotic cell cycle | larval stage (with Df(2R)BSC298)

(Cenci et al., 2015)

abnormal mitotic cell cycle | larval stage (with peo¹⁵²⁷)

(Cenci et al., 2015)

abnormal mitotic cell cycle | larval stage (with peo²⁷²³)

(Cenci et al., 2015)

abnormal mitotic cell cycle | larval stage (with peo^h)

(Cenci et al., 2015)

abnormal mitotic cell cycle | larval stage (with peo^p112)

(Cenci et al., 2015)

lethal - all die before end of larval stage

(Cenci et al., 2015)

lethal - all die before end of larval stage (with Df(2R)221)

(Cenci et al., 2015)

lethal - all die before end of larval stage (with Df(2R)520)

(Cenci et al., 2015)

lethal - all die before end of larval stage (with peo¹⁵²⁷)

(Cenci et al., 2015)

lethal - all die before end of larval stage (with peo²⁷²³)

(Cenci et al., 2015)

lethal - all die before end of larval stage (with peo^h)

(Cenci et al., 2015)

lethal - all die before end of larval stage (with peo^p112)

(Cenci et al., 2015)

Phenotype Manifest In

chromosome | larval stage

(Cenci et al., 2015)

chromosome | larval stage (with Df(2R)221)

(Cenci et al., 2015)

chromosome | larval stage (with Df(2R)520)

(Cenci et al., 2015)

chromosome | larval stage (with Df(2R)BSC298)

(Cenci et al., 2015)

chromosome | larval stage (with peo¹⁵²⁷)

(Cenci et al., 2015)

chromosome | larval stage (with peo²⁷²³)

(Cenci et al., 2015)

chromosome | larval stage (with peo^h)

(Cenci et al., 2015)

chromosome | larval stage (with peo^p112)

(Cenci et al., 2015)

larval neuroblast

(Cenci et al., 2015)

larval neuroblast (with Df(2R)221)

(Cenci et al., 2015)

larval neuroblast (with Df(2R)520)

(Cenci et al., 2015)

larval neuroblast (with Df(2R)BSC298)

(Cenci et al., 2015)

larval neuroblast (with peo¹⁵²⁷)

(Cenci et al., 2015)

larval neuroblast (with peo²⁷²³)

(Cenci et al., 2015)

larval neuroblast (with peo^h)

(Cenci et al., 2015)

larval neuroblast (with peo^p112)

(Cenci et al., 2015)

Detailed Description

Statement

Reference

peo¹/peo¹, peo¹/peo^h, peo¹/peo¹⁵²⁷, peo¹/peo²⁷²³, peo¹/peo^p112, peo¹/Df(2R)520, peo¹/Df(2R)221 and peo¹/Df(2R)BSC298 larval neuroblasts exhibit telomeric fusions, often resulting in multicentric linear chromosomes that resemble little "trains" of chromosomes; peo¹/peo^h larval brains exhibit high frequencies of telomeric fusions between heterochromatin-associated telomeres. peo^h/peo¹ larval neuroblasts exhibit Y rings.