FlyBase Allele Report: Dmel\peo[h]

General Information

Symbol

Dmel\peo^h

Species

D. melanogaster

Name

FlyBase ID

FBal0374466

Feature type

allele

Associated gene

Dmel\peo

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - molecular evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Cenci et al., 2015)

Mutagen

ethyl methanesulfonate

(Cenci et al., 2015)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle | larval stage

(Cenci et al., 2015)

abnormal mitotic cell cycle | larval stage (with Df(2R)221)

(Cenci et al., 2015)

abnormal mitotic cell cycle | larval stage (with Df(2R)520)

(Cenci et al., 2015)

abnormal mitotic cell cycle | larval stage (with Df(2R)BSC298)

(Cenci et al., 2015)

abnormal mitotic cell cycle | larval stage (with peo¹)

(Cenci et al., 2015)

abnormal mitotic cell cycle | larval stage (with peo¹⁵²⁷)

(Cenci et al., 2015)

abnormal mitotic cell cycle | larval stage (with peo²⁷²³)

(Cenci et al., 2015)

abnormal mitotic cell cycle | larval stage (with peo^p112)

(Cenci et al., 2015)

lethal - all die before end of larval stage (with Df(2R)221)

(Cenci et al., 2015)

lethal - all die before end of larval stage (with Df(2R)520)

(Cenci et al., 2015)

lethal - all die before end of larval stage (with peo¹)

(Cenci et al., 2015)

lethal - all die before end of larval stage (with peo¹⁵²⁷)

(Cenci et al., 2015)

lethal - all die before end of larval stage (with peo²⁷²³)

(Cenci et al., 2015)

lethal - all die before end of larval stage (with peo^p112)

(Cenci et al., 2015)

sterile

(Cenci et al., 2015)

Phenotype Manifest In

chromosome | larval stage

(Cenci et al., 2015)

chromosome | larval stage (with Df(2R)BSC298)

(Cenci et al., 2015)

chromosome | larval stage (with peo¹)

(Cenci et al., 2015)

larval neuroblast

(Cenci et al., 2015)

larval neuroblast (with Df(2R)BSC298)

(Cenci et al., 2015)

larval neuroblast (with peo¹)

(Cenci et al., 2015)

Detailed Description

Statement

Reference

peo^h/peo^h, peo¹/peo^h, peo^h/peo¹⁵²⁷, peo^h/peo²⁷²³, peo^h/peo^p112, peo^h/Df(2R)520, peo^h/Df(2R)221 and peo^h/Df(2R)BSC298 larval neuroblasts exhibit telomeric fusions, often resulting in multicentric linear chromosomes that resemble little "trains" of chromosomes. larval neuroblasts exhibit telomeric fusions, often resulting in multicentric linear chromosomes that resemble little "trains" of chromosome. In the peo^h homozygotes, almost all telomere fusions involve the telomeres associated the heterochromatic regions of the chromosomes, namely Y chromosome, right arm of X chromosome and fourth chromosome; peo¹/peo^h and peo^h/Df(2R)BSC298 larval brains also exhibit high frequencies of telomeric fusions between heterochromatin-associated telomeres. peo^h/peo^h, peo^h/peo¹ and peo^h/Df(2R)BSC298 larval neuroblasts exhibit Y rings.

peo^h/peo^h larval brains exhibit a decrease in DNA replication.

(Cenci et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

peo^h is partially rescued by peo^Tub.Tag:HA

(Cenci et al., 2015)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

peo^h

(Porrazzo et al., 2022, Cenci et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

Open Close