FlyBase Allele Report: Dmel\Gba1b[Δ1]

General Information

Symbol

Dmel\Gba1b^Δ1

Species

D. melanogaster

Name

FlyBase ID

FBal0385505

Feature type

allele

Associated gene

Dmel\Gba1b

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Vaughen et al., 2022)

Progenitor genotype

Cytology

Description

10bp deletion; generates an early frameshift in Gba1b.

(Vaughen et al., 2022)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal circadian rhythm (with Df(3R)GBA1^ΔTT)

(Vaughen et al., 2022)

abnormal neuroanatomy | adult stage (with Df(3R)GBA1^ΔTT)

(Vaughen et al., 2022)

abnormal neuroanatomy | adult stage (with Df(3R)GBA1^ΔTT), with Gba1b^20xUAS.cVa, Scer\GAL4^Pdf.PU

(Vaughen et al., 2022)

abnormal sleep | adult stage (with Df(3R)GBA1^ΔTT)

(Vaughen et al., 2022)

decreased sleep | adult stage (with Df(3R)GBA1^ΔTT)

(Vaughen et al., 2022)

viable (with Df(3R)GBA1^ΔTT)

(Vaughen et al., 2022)

Phenotype Manifest In

adult brain (with Df(3R)GBA1^ΔTT)

(Vaughen et al., 2022)

adult s-LNv neuron | adult stage (with Df(3R)GBA1^ΔTT)

(Vaughen et al., 2022)

adult s-LNv neuron | adult stage (with Df(3R)GBA1^ΔTT), with Gba1b^20xUAS.cVa, Scer\GAL4^Pdf.PU

(Vaughen et al., 2022)

calyx of adult mushroom body (with Df(3R)GBA1^ΔTT)

(Vaughen et al., 2022)

lysosome | adult stage (with Df(3R)GBA1^ΔTT)

(Vaughen et al., 2022)

optic chiasma | adult stage (with Df(3R)GBA1^ΔTT)

(Vaughen et al., 2022)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Gba1b^Δ1/Df(3R)GBA1^ΔTT has lysosome | adult stage phenotype, enhanceable by per⁰¹

(Vaughen et al., 2022)

Gba1b^Δ1/Df(3R)GBA1^ΔTT has adult brain phenotype, enhanceable by per⁰¹

(Vaughen et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Gba1b^Δ1/Df(3R)GBA1^ΔTT is rescued by Scer\GAL4^repo/Gba1b^{20xUAS.Tag:TM(Lamp1),Tag:V5}

(Vaughen et al., 2022)

Gba1b^Δ1/Df(3R)GBA1^ΔTT is rescued by Scer\GAL4^GMR56F03/Gba1b^{20xUAS.Tag:TM(Lamp1),Tag:V5}

(Vaughen et al., 2022)

Gba1b^Δ1/Df(3R)GBA1^ΔTT is rescued by Scer\GAL4^GMR56F03/Gba1b^20xUAS.cVa

(Vaughen et al., 2022)

Gba1b^Δ1/Df(3R)GBA1^ΔTT is rescued by Scer\GAL4^GMR56F03/Scer\GAL4^GMR85G01/Gba1b^20xUAS.cVa

(Vaughen et al., 2022)

Gba1b^Δ1/Df(3R)GBA1^ΔTT is rescued by Scer\GAL4^{Gba1b-CR00541-TG4.0}/Gba1b^20xUAS.cVa

(Vaughen et al., 2022)

Gba1b^Δ1/Df(3R)GBA1^ΔTT is rescued by Gba1b^{20xUAS.mCherry}/Scer\GAL4^{Gba1b-CR00541-TG4.0}

(Vaughen et al., 2022)

Gba1b^Δ1/Df(3R)GBA1^ΔTT is rescued by Gba1b^{20xUAS.mCherry}/Scer\GAL4^repo

(Vaughen et al., 2022)

Gba1b^Δ1/Df(3R)GBA1^ΔTT is rescued by Gba1b^GMR57C10

(Vaughen et al., 2022)

Not rescued by

Gba1b^Δ1/Df(3R)GBA1^ΔTT is not rescued by Scer\GAL4^GMR86E01/Gba1b^20xUAS.cVa

(Vaughen et al., 2022)

Gba1b^Δ1/Df(3R)GBA1^ΔTT is not rescued by Scer\GAL4^Pdf.PU/Gba1b^20xUAS.cVa

(Vaughen et al., 2022)

Gba1b^Δ1/Df(3R)GBA1^ΔTT is not rescued by Scer\GAL4^GMR56F03/Gba1b^E404K.20xUAS

(Vaughen et al., 2022)

Gba1b^Δ1/Df(3R)GBA1^ΔTT is not rescued by Scer\GAL4^Pdf.PU/Gba1b^E404K.20xUAS

(Vaughen et al., 2022)

Gba1b^Δ1/Df(3R)GBA1^ΔTT is not rescued by Scer\GAL4^{Gba1b-CR00541-TG4.0}/Gba1b^E404K.20xUAS

(Vaughen et al., 2022)

Gba1b^Δ1/Df(3R)GBA1^ΔTT is not rescued by Scer\GAL4^repo/Gba1b^E404K.20xUAS

(Vaughen et al., 2022)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

97395

Gba1b^Δ1

97394

w^*; Gba1a^Delta1 Gba1b^Δ1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Gba1b^Δ1

gba1b^Δ1

(Vaughen et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections