FlyBase Allele Report: Dmel\Parp1[c03256]

General Information

Symbol

Dmel\Parp1^c03256

Species

D. melanogaster

Name

FlyBase ID

FBal0388057

Feature type

allele

Associated gene

Dmel\Parp1

Associated Insertion(s)

PBac{PB}Parp1^c03256

Carried in Construct

Also Known As

Parp^c03256

Key Links

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Ji and Tulin, 2009)

Mutagen

Progenitor genotype

Associated Insertion(s)

PBac{PB}Parp1^c03256

Cytology

Description

Insertion in exon 4 of Parp.

(Kotova et al., 2010)

Allele components

Component

Use(s)

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | second instar larval stage

(Kotova et al., 2010)

lethal | third instar larval stage

(Kotova et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

27% of homozygotes survive up to the pupal stage, but most die as second or third instar larvae.

(Kotova et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Parp1^c03256 has lethal phenotype, suppressible | partially by Parg^27.1/Parg[+]

(Kotova et al., 2010)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The viability of Parg^27.1/+; Parp^c03256/Parp^c03256 animals after exposure to 36Gy irradiation at the third larval instar stage is not significantly different from that of wild-type controls.

(Kotova et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Parp1^c03256 is rescued by Parp1^{I.UAS.DsRed(Unk)}/Scer\GAL4^G1

(Kotova et al., 2010)

Partially rescued by

Parp1^c03256 is partially rescued by Parp1^{Δ300.UAS.EYFP}/Scer\GAL4^G1

(Kotova et al., 2010)

Not rescued by

Parp1^c03256 is not rescued by Parp1^e.UAS.EGFP/Scer\GAL4^G1

(Kotova et al., 2010)

Comments

The lethality of Parp^c03256 homozygotes is completely rescued by expression of Parp^{I.Scer\UAS.T:Disc\RFP} under the control of Scer\GAL4^G1, but is not rescued by expression of Parp^{e.Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^G1.

Expression of Parp^{Δ300.Scer\UAS.T:Avic\GFP-EYFP} under the control of Scer\GAL4^G1 partially rescues the lethality of Parp^c03256 homozygotes.

(Kotova et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Precise excision of the insertion reverts the lethal phenotype.

(Kotova et al., 2010)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

Parp1^c03256

Parp⁰³²⁵⁶

(Ong et al., 2013)

Parp^C03256

(Ong et al., 2013, Sala et al., 2008)

Parp^C03265

(Boamah et al., 2012)

Parp^c03256

(Kotova et al., 2011)

parp-1^C03256

(Thomas et al., 2019)

parp^C03256

(Thomas et al., 2019, Ji et al., 2016, Kotova et al., 2010)

Name Synonyms

poly(ADP-ribose) glycohydrolase

(Kotova et al., 2011)

Secondary FlyBase IDs

FBal0230479
FBal0246167

References (8)

Report Sections

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