FlyBase Allele Report: Dmel\Nazo[KO]

General Information

Symbol

Dmel\Nazo^KO

Species

D. melanogaster

Name

FlyBase ID

FBal0399912

Feature type

allele

Associated gene

Dmel\Nazo

Associated Insertion(s)

TI{TI}Nazo^KO

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Sreejith et al., 2024)

Mutagen

CRISPR/Cas9

(Sreejith et al., 2024)

gene targeting by homologous recombination

(Sreejith et al., 2024)

Progenitor genotype

Associated Insertion(s)

TI{TI}Nazo^KO

Cytology

Description

657bp deletion that includes the Nazo translation start site.

(Sreejith et al., 2024)

Allele components

Component

Use(s)

Also carries

attP

integrase target site

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of neurodegeneration with brain iron accumulation 4

CEC

(Sreejith et al., 2024)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of neurodegeneration with brain iron accumulation 4

is ameliorated by Lsd-2^UAS.cGa

(Sreejith et al., 2024)

is ameliorated by bmm^JF01946

(Sreejith et al., 2024)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult fat body

(Sreejith et al., 2024)

adult gut

(Sreejith et al., 2024)

adult midgut

(Sreejith et al., 2024)

crop | adult stage | nutrition conditional

(Sreejith et al., 2024)

lipid droplet | adult stage

(Sreejith et al., 2024)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

CG3740^CRISPR, Nazo^KO has short lived phenotype

(Sreejith et al., 2024)

CG3740^CRISPR, Nazo^KO has abnormal starvation stress response | adult stage phenotype

(Sreejith et al., 2024)

CG3740^CRISPR, Nazo^KO has abnormal oxidative stress response | adult stage phenotype

(Sreejith et al., 2024)

CG3740^CRISPR, Nazo^KO has decreased rate of adult locomotory behavior | progressive phenotype

(Sreejith et al., 2024)

CG3740^CRISPR, Nazo^KO has increased mortality | nutrition conditional phenotype

(Sreejith et al., 2024)

CG3740^CRISPR, Nazo^KO has increased size | adult stage | nutrition conditional phenotype

(Sreejith et al., 2024)

Phenotype Manifest In

Other

Statement

Reference

CG3740^CRISPR, Nazo^KO has adult midgut phenotype

(Sreejith et al., 2024)

CG3740^CRISPR, Nazo^KO has adult fat body phenotype

(Sreejith et al., 2024)

CG3740^CRISPR, Nazo^KO has lipid droplet | adult stage phenotype

(Sreejith et al., 2024)

CG3740^CRISPR, Nazo^KO has crop | adult stage | nutrition conditional phenotype

(Sreejith et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Nazo^KO is rescued by Scer\GAL4^NP0001/Nazo^UAS.Tag:MYC

(Sreejith et al., 2024)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Nazo^KO

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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