FlyBase Allele Report: Dmel\bmm[JF01946]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\bmm^JF01946

General Information

Symbol

Dmel\bmm^JF01946

Species

D. melanogaster

Name

FlyBase ID

FBal0219932

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{TRiP.JF01946}

Also Known As

UAS-bmm-RNAi, UAS-bmm RNAi, UAS-bmm^RNAi

Key Links

Genomic Maps

Transgenic product class

(Perkins et al., 2009.1.15)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Perkins et al., 2009.1.15)

Mutagen

in vitro construct

(Perkins et al., 2009.1.15)

Progenitor genotype

Carried in construct

P{TRiP.JF01946}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.1.15)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Also carries

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\GGGGCC^36.UAS

(Le et al., 2024)

ameliorates neurodegeneration with brain iron accumulation 4

modeled by Nazo^KO

(Sreejith et al., 2024)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal starvation stress response | adult stage | female, with Scer\GAL4^Cg.PU

(Wat et al., 2020)

abnormal starvation stress response | adult stage | female, with Scer\GAL4^da.PU

(Wat et al., 2020)

abnormal starvation stress response | adult stage | female, with Scer\GAL4^nSyb.PU

(Wat et al., 2020)

abnormal starvation stress response | adult stage | female, with Scer\GAL4^r4

(Wat et al., 2020)

abnormal starvation stress response | adult stage | female, with Scer\GAL4^tj.PU

(Wat et al., 2020)

abnormal starvation stress response | adult stage | male, with Scer\GAL4^C587

(Wat et al., 2020)

abnormal starvation stress response | adult stage | male, with Scer\GAL4^Cg.PU

(Wat et al., 2020)

abnormal starvation stress response | adult stage | male, with Scer\GAL4^da.PU

(Wat et al., 2020)

abnormal starvation stress response | adult stage | male, with Scer\GAL4^elav.PU

(Wat et al., 2020)

abnormal starvation stress response | adult stage | male, with Scer\GAL4^Mef2.PU

(Wat et al., 2020)

abnormal starvation stress response | adult stage | male, with Scer\GAL4^nSyb.PU

(Wat et al., 2020)

abnormal starvation stress response | adult stage | male, with Scer\GAL4^r4

(Wat et al., 2020)

abnormal starvation stress response | adult stage | male, with Scer\GAL4^tj.PU

(Wat et al., 2020)

decreased efficacy of memory | adult stage | calorie restriction conditional, with Scer\GAL4^GMR54H02

(Silva et al., 2022)

increased size | adult stage, with Scer\GAL4^Lsp2.3.1

(Grmai et al., 2024)

Phenotype Manifest In

adult brain | calorie restriction conditional, with Scer\GAL4^GMR54H02

(Silva et al., 2022)

adult fat body, with Scer\GAL4^Lsp2.3.1

(Grmai et al., 2024)

adult optic lobe glial cell, with Scer\GAL4^54C

(Girard et al., 2021)

adult optic lobe glial cell, with Scer\GAL4^GMR.PU

(Girard et al., 2021)

lipid droplet | adult stage, with Scer\GAL4^Lsp2.3.1

(Grmai et al., 2024)

lipid droplet | adult stage | calorie restriction conditional, with Scer\GAL4^GMR54H02

(Silva et al., 2022)

lipid droplet | adult stage | increased number, with Scer\GAL4^54C

(Girard et al., 2021)

lipid droplet | adult stage | increased number, with Scer\GAL4^GMR.PU

(Girard et al., 2021)

retina | adult stage, with Scer\GAL4^54C

(Girard et al., 2021)

retina | adult stage, with Scer\GAL4^GMR.PU

(Girard et al., 2021)

Detailed Description

Statement

Reference

Adults expressing bmm^JF01946 for 2 days under the combined control of Scer\GAL4^GMR54H02 and Gal80[ts] (for temporal control of expression) exhibit decreased associative olfactory memory under starvation conditions, but not when fed. Starvation induces enlarged lipid droplets in the brain region where cortex glia enwrap mushroom body neuronal soma.

(Silva et al., 2022)

Expression of bmm^JF01946 under the control of Scer\GAL4^da.PU, Scer\GAL4^Cg.PU, Scer\GAL4^r4, Scer\GAL4^tj.PU or Scer\GAL4^nSyb.PU leads to an increase in starvation resistance in both males and females.

Expression of bmm^JF01946 under the control of Scer\GAL4^C587 or Scer\GAL4^elav.PU or Scer\GAL4^Mef2.PU leads to an increase in starvation resistance in males.

(Wat et al., 2020)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

bmm^JF01946, Scer\GAL4^ninaE.PT is a non-enhancer of photoreceptor neuron | adult stage phenotype of Lsd-2^UAS.EGFP, Scer\GAL4^ninaE.PT

(Girard et al., 2021)

bmm^JF01946, Scer\GAL4^ninaE.PT is a non-enhancer of lipid droplet | adult stage | increased number phenotype of Lsd-2^UAS.EGFP, Scer\GAL4^ninaE.PT

(Girard et al., 2021)

Suppressor of

Statement

Reference

Scer\GAL4^NP0001/bmm^JF01946 is a suppressor of lipid droplet | adult stage phenotype of CG3740^CRISPR, Nazo^RNAi.UAS.cSa, Scer\GAL4^Act5C.PI

(Sreejith et al., 2024)

Scer\GAL4^NP0001/bmm^JF01946 is a suppressor of adult midgut phenotype of CG3740^CRISPR, Nazo^RNAi.UAS.cSa, Scer\GAL4^Act5C.PI

(Sreejith et al., 2024)

bmm^JF01946, Scer\GAL4^NP0001 is a suppressor of lipid droplet | adult stage phenotype of Nazo^RNAi.UAS.cSa, Scer\GAL4^NP0001

(Sreejith et al., 2024)

bmm^JF01946, Scer\GAL4^NP0001 is a suppressor of adult midgut phenotype of Nazo^RNAi.UAS.cSa, Scer\GAL4^NP0001

(Sreejith et al., 2024)

NOT Suppressor of

Statement

Reference

bmm^JF01946, Scer\GAL4^ninaE.PT is a non-suppressor of photoreceptor neuron | adult stage phenotype of Lsd-2^UAS.EGFP, Scer\GAL4^ninaE.PT

(Girard et al., 2021)

bmm^JF01946, Scer\GAL4^ninaE.PT is a non-suppressor of lipid droplet | increased number | adult stage phenotype of Lsd-2^UAS.EGFP, Scer\GAL4^ninaE.PT

(Girard et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

bmm^JF01946 is rescued by Scer\GAL4^C587/bmm^UAS.cUa

(Wat et al., 2020)

bmm^JF01946 is rescued by Scer\GAL4^elav.PU/bmm^UAS.cUa

(Wat et al., 2020)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

25926

y¹ v¹; P{TRiP.JF01946}attP2/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

bmm^JF01946

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections