FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\NagluKO
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General Information
Symbol
Dmel\NagluKO
Species
D. melanogaster
Name
FlyBase ID
FBal0408254
Feature type
allele
Associated gene
Dmel\Naglu
Associated Insertion(s)
TI{TI}NagluKO
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Mast and DiPrimio, 2019.5.31)

loss of function allele

(Simkhada et al., 2025)
Mutagen
gene targeting by homologous recombination
(Simkhada et al., 2025, Mast and DiPrimio, 2019.5.31)
CRISPR/Cas9
(Simkhada et al., 2025, Mast and DiPrimio, 2019.5.31)
Progenitor genotype
Associated Insertion(s)
TI{TI}NagluKO
Cytology
Description

CRISPR/Cas9 induced deletion of endogenous Naglu.

(Simkhada et al., 2025)

CG13397 sequence from -21 bp relative to the ATG codon through to -91 bp from the stop codon has been deleted and replaced with sequence that comprises 1. a loxP cassette that carries a Disc\RFP3xP3.cUa marker and 2. a single attP site.

(Mast and DiPrimio, 2019.5.31)
Allele components
Component
Use(s)
Also carries
attP
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:8,409,222..8,411,565 [-]
Comment:

CG13397 sequence from -21 bp relative to the ATG codon through to -91 bp from the stop codon has been deleted and replaced with sequence that comprises 1. a loxP cassette that carries a Disc\RFP3xP3.cUa marker and 2. a single attP site.

(Simkhada et al., 2025, Mast and DiPrimio, 2019.5.31)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  mucopolysaccharidosis type IIIB
      CEA
      (Simkhada et al., 2025)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CG13397KO
      NagluKO.S
      NagluKO
      (Simkhada et al., 2025)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0407854
      • FBal0349324
      References (3)